Overall structure of Erastin-bound xCT-4F2hc complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7epz
Q-score: 0.486
Yan R, Xie E, Li Y, Li J, Zhang Y, Chi X, Hu X, Xu L, Hou T, Stockwell BR, Min J, Zhou Q, Wang F
Cell Res (2022) 32 pp. 687-690 [ Pubmed: 35352032 DOI: doi:10.1038/s41422-022-00642-w ]
- Cystine/glutamate transporter (57 kDa, Protein from Homo sapiens)
- 2-[(1s)-1-[4-[2-(4-chloranylphenoxy)ethanoyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one (547 Da, Ligand)
- Overall structure of erastin-bound xct-4f2hc complex (Complex from Homo sapiens)
- 1,2-distearoyl-sn-glycero-3-phosphate (703 Da, Ligand)
- 4f2 cell-surface antigen heavy chain (70 kDa, Protein from Homo sapiens)
Human Tom70 in complex with SARS CoV2 Orf9b
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 7kdt
Q-score: 0.473
Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Huttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbolle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss 3rd FR, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech Jr TH, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat KM, Garcia-Sastre A, Rassen JA, Grosse R, Rosenberg OS, Verba KA, Basler CF, Vignuzzi M, Peden AA, Beltrao P, Krogan NJ
Science (2020) 370 [ DOI: doi:10.1126/science.abe9403 Pubmed: 33060197 ]
- Orf9b protein (10 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Mitochondrial import receptor subunit tom70 (56 kDa, Protein from Homo sapiens)
- Orf9b-tom70 complex (Complex from Homo sapiens)
human KCC1 structure determined in KCl and detergent GDN
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6kkr
Q-score: 0.559
Liu S, Chang S, Han B, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J, Delpire E, Ye S, Bai XC, Guo J
Science (2019) 366 pp. 505-508 [ Pubmed: 31649201 DOI: doi:10.1126/science.aay3129 ]
- Potassium ion (39 Da, Ligand)
- Solute carrier family 12 member 4 (122 kDa, Protein from Homo sapiens)
- Potassium chloride co-transporter 1 (Complex from Homo sapiens)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
- Chloride ion (35 Da, Ligand)
human KCC1 structure determined in KCl and lipid nanodisc
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 6kkt
Q-score: 0.559
Liu S, Chang S, Han B, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J, Delpire E, Ye S, Bai XC, Guo J
Science (2019) 366 pp. 505-508 [ Pubmed: 31649201 DOI: doi:10.1126/science.aay3129 ]
- Potassium ion (39 Da, Ligand)
- Solute carrier family 12 member 4 (122 kDa, Protein from Homo sapiens)
- Potassium chloride co-transporter 1 (Complex from Homo sapiens)
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
- Chloride ion (35 Da, Ligand)
human KCC1 structure determined in NaCl and GDN
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6kku
Q-score: 0.469
Liu S, Chang S, Han B, Xu L, Zhang M, Zhao C, Yang W, Wang F, Li J, Delpire E, Ye S, Bai XC, Guo J
Science (2019) 366 pp. 505-508 [ Pubmed: 31649201 DOI: doi:10.1126/science.aay3129 ]
- 2-[2-[(1~{s},2~{s},4~{s},5'~{r},6~{r},7~{s},8~{r},9~{s},12~{s},13~{r},16~{s})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol (516 Da, Ligand)
- Potassium chloride co-transporter 1 (Complex from Homo sapiens)
- Solute carrier family 12 member 4 (122 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)