Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
- Tetradecane (198 Da, Ligand)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Tamsulosin (408 Da, Ligand)
Structure of the semi-extended AlphaIIbBeta3 in complex with R21D10 Fab
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9axl
Q-score: 0.473
Wang L, Wang J, Li J, Walz T, Coller BS
Blood Adv (2024) 8 pp. 4398-4409 [ DOI: doi:10.1182/bloodadvances.2024013177 Pubmed: 38968144 ]
- Calcium ion (40 Da, Ligand)
- Integrin beta-3 (87 kDa, Protein from Homo sapiens)
- Integrin alpha-iib (113 kDa, Protein from Homo sapiens)
- The semi-extended alphaiibbeta3 in complex with r21d10 fab (250 kDa, Complex)
- Magnesium ion (24 Da, Ligand)
- R21d10 fab light chain (23 kDa, Protein from Mus musculus)
- R21d10 fab heavy chain (24 kDa, Protein from Mus musculus)
- Water (18 Da, Ligand)
The map of the bent AlphaIIbBeta3 in complex with R21D10 Fab
Wang L, Wang J, Li J, Walz T, Coller BS
Blood Adv (2024) 8 pp. 4398-4409 [ DOI: doi:10.1182/bloodadvances.2024013177 Pubmed: 38968144 ]
- Integrin alphaiib (Protein from Homo sapiens)
- Alphaiibbeta3 integrin (Complex from Homo sapiens)
- Integrin beta3 (Protein from Homo sapiens)
- R21d10 fab (Complex from Mus musculus)
- R211010 fab light chain (Protein from Mus musculus)
- The semi-extended alphaiibbeta3 in complex with r21d10 fab (250 kDa, Complex)
- R21d10 fab heavy chain (Protein from Mus musculus)
Structure of TbAQP2 in complex with anti-trypanosomatid drug melarsoprol
Structure of the TbAQP2 in the apo conformation
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8jy7
Q-score: 0.53
Chen W, Zou R, Mei Y, Li J, Xuan Y, Cui B, Zou J, Wang J, Lin S, Zhang Z, Wang C
Nat Commun (2024) 15 pp. 3985-3985 [ DOI: doi:10.1038/s41467-024-48445-4 Pubmed: 38734677 ]
- Aquaglyceroporin 2 (36 kDa, Protein from Trypanosoma brucei brucei)
- Tetramer of tbaqp2 (Complex from Trypanosoma brucei brucei)
Structure of TbAQP2 in complex with anti-trypanosomatid drug pentamidine
Resolution: 2.45 Å
EM Method: Single-particle
Fitted PDBs: 8jy8
Q-score: 0.611
Chen W, Zou R, Mei Y, Li J, Xuan Y, Cui B, Zou J, Wang J, Lin S, Zhang Z, Wang C
Nat Commun (2024) 15 pp. 3985-3985 [ DOI: doi:10.1038/s41467-024-48445-4 Pubmed: 38734677 ]
- 1,5-bis(4-amidinophenoxy)pentane (340 Da, Ligand)
- Tbaqp2 complex with pentamidine (Complex from Trypanosoma brucei brucei)
- Aquaglyceroporin 2 (33 kDa, Protein from Trypanosoma brucei brucei)
Human gamma-secretase treated with ganglioside GM1
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8im7
Q-score: 0.483
Wang X, Zhou R, Sun X, Li J, Wang J, Yue W, Wang L, Liu H, Shi Y, Zhang D
Adv Sci (2023) 10 pp. e2303411-e2303411 [ DOI: doi:10.1002/advs.202303411 Pubmed: 37759382 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 ctf12 (52 kDa, Protein from Homo sapiens)
- Human gamma-secretase treated with ganglioside gm1 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Conformational Dynamics of the D53-D3-D14 Complex in Strigolactone Signaling
Resolution: 7.09 Å
EM Method: Single-particle
Fitted PDBs: 8if6
Q-score: 0.121
Liu S, Wang J, Song B, Gong X, Liu H, Hu Q, Zhang J, Li Q, Zheng J, Wang H, Xu HE, Li J, Wang B
Plant Cell Physiol (2023) 64 pp. 1046-1056 [ Pubmed: 37384578 DOI: doi:10.1093/pcp/pcad067 ]
- F-box/lrr-repeat max2 homolog (79 kDa, Protein from Oryza sativa subsp. japonica)
- Plant protein complex (Complex from Oryza sativa)
- Skp1-like protein 20 (19 kDa, Protein from Oryza sativa subsp. japonica)
- Strigolactone esterase d14 (33 kDa, Protein from Oryza sativa subsp. japonica)
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 7fjn
Q-score: 0.27
Liang Q, Wang Y, Zhang S, Sun J, Sun W, Li J, Liu Y, Li M, Cheng L, Jiang Y, Wang R, Zhang R, Yang Z, Ren Y, Chen P, Gao P, Yan H, Zhang Z, Zhang Q, Shi X, Wang J, Liu W, Wang X, Ying B, Zhao J, Qi H, Zhang L
iScience (2022) 25 pp. 104043-104043 [ Pubmed: 35291264 DOI: doi:10.1016/j.isci.2022.104043 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- S protein of south african (b.1.351) sars-cov-2 (Complex from Homo sapiens)
- T6 light chain (12 kDa, Protein from Homo sapiens)
- T6 heavy chain (12 kDa, Protein from Homo sapiens)
- T6 fab (Complex)
- Spike glycoprotein,envelope glycoprotein (141 kDa, Protein from Human immunodeficiency virus 1)
- S protein of south african (b.1.351) sars-cov-2 spike in complex with t6 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 7fjo
Q-score: 0.106
Liang Q, Wang Y, Zhang S, Sun J, Sun W, Li J, Liu Y, Li M, Cheng L, Jiang Y, Wang R, Zhang R, Yang Z, Ren Y, Chen P, Gao P, Yan H, Zhang Z, Zhang Q, Shi X, Wang J, Liu W, Wang X, Ying B, Zhao J, Qi H, Zhang L
iScience (2022) 25 pp. 104043-104043 [ Pubmed: 35291264 DOI: doi:10.1016/j.isci.2022.104043 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- T6 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- T6 heavy chain (23 kDa, Protein from Homo sapiens)
- T6 light chain (24 kDa, Protein from Homo sapiens)
- S protein of south african (b.1.351) sars-cov-2 spike in complex with t6 fab (Complex from Homo sapiens)
- S protein of south african (b.1.351) sars-cov-2 spike (Complex)