Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
- Tetradecane (198 Da, Ligand)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Tamsulosin (408 Da, Ligand)
Structure of TbAQP2 in complex with anti-trypanosomatid drug melarsoprol
Structure of the TbAQP2 in the apo conformation
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8jy7
Q-score: 0.53
Chen W, Zou R, Mei Y, Li J, Xuan Y, Cui B, Zou J, Wang J, Lin S, Zhang Z, Wang C
Nat Commun (2024) 15 pp. 3985-3985 [ DOI: doi:10.1038/s41467-024-48445-4 Pubmed: 38734677 ]
- Aquaglyceroporin 2 (36 kDa, Protein from Trypanosoma brucei brucei)
- Tetramer of tbaqp2 (Complex from Trypanosoma brucei brucei)
Structure of TbAQP2 in complex with anti-trypanosomatid drug pentamidine
Resolution: 2.45 Å
EM Method: Single-particle
Fitted PDBs: 8jy8
Q-score: 0.611
Chen W, Zou R, Mei Y, Li J, Xuan Y, Cui B, Zou J, Wang J, Lin S, Zhang Z, Wang C
Nat Commun (2024) 15 pp. 3985-3985 [ DOI: doi:10.1038/s41467-024-48445-4 Pubmed: 38734677 ]
- 1,5-bis(4-amidinophenoxy)pentane (340 Da, Ligand)
- Tbaqp2 complex with pentamidine (Complex from Trypanosoma brucei brucei)
- Aquaglyceroporin 2 (33 kDa, Protein from Trypanosoma brucei brucei)
The structure of human Integrator-PP2A complex
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7cun
Q-score: 0.35
Zheng H, Qi Y, Hu S, Cao X, Xu C, Yin Z, Chen X, Li Y, Liu W, Li J, Wang J, Wei G, Liang K, Chen FX, Xu Y
Science (2020) 370 [ DOI: doi:10.1126/science.abb5872 Pubmed: 33243860 ]
- Integrator complex subunit 9 (73 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Human integrator-pp2a complex (Complex)
- Integrator complex subunit 11 (67 kDa, Protein from Homo sapiens)
- Integrator complex subunit 4 (108 kDa, Protein from Homo sapiens)
- Unknown subunit (Complex from Homo sapiens)
- Pp2a-c (35 kDa, Protein from Homo sapiens)
- Integrator complex subunit 1, 2, 4, 5, 6, 7, 8, 9, 11 (Complex from Homo sapiens)
- Integrator complex subunit 6 (100 kDa, Protein from Homo sapiens)
- Pp2a-a (66 kDa, Protein from Homo sapiens)
- Pp2a (Complex from Homo sapiens)
- Unknown (50 kDa, Protein from Homo sapiens)
- Integrator complex subunit 7 (106 kDa, Protein from Homo sapiens)
- Integrator complex subunit 1 (244 kDa, Protein from Homo sapiens)
- Manganese (ii) ion (54 Da, Ligand)
- Integrator complex subunit 2 (134 kDa, Protein from Homo sapiens)
- Integrator complex subunit 5 (108 kDa, Protein from Homo sapiens)
- Integrator complex subunit 8 (113 kDa, Protein from Homo sapiens)
Cryo-EM structure of the receptor-activated TRPC5 ion channel
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 6aei
Q-score: 0.484
Duan J, Li J, Chen GL, Ge Y, Liu J, Xie K, Peng X, Zhou W, Zhong J, Zhang Y, Xu J, Xue C, Liang B, Zhu L, Liu W, Zhang C, Tian XL, Wang J, Clapham DE, Zeng B, Li Z, Zhang J
Sci Adv (2019) 5 [ DOI: doi:10.1126/sciadv.aaw7935 Pubmed: 31355338 ]
- Sodium ion (22 Da, Ligand)
- Mouse trpc5 (Complex from Mus musculus)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
- Short transient receptor potential channel 5 (88 kDa, Protein from Mus musculus)
- Cholesterol hemisuccinate (486 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6cmx
Q-score: 0.497
Li J, Shalev-Benami M, Sando R, Jiang X, Kibrom A, Wang J, Leon K, Katanski C, Nazarko O, Lu YC, Sudhof TC, Skiniotis G, Arac D
Cell (2018) 173 pp. 735-748.e15 [ Pubmed: 29677516 DOI: doi:10.1016/j.cell.2018.03.036 ]
- Alpha-d-mannopyranose (180 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Teneurin-2 (224 kDa, Protein from Homo sapiens)
- Teneurin 2 extra-cellular region (215 kDa, Cellular component from Homo sapiens)
