Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
- Tetradecane (198 Da, Ligand)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Tamsulosin (408 Da, Ligand)
Human gamma-secretase treated with ganglioside GM1
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8im7
Q-score: 0.483
Wang X, Zhou R, Sun X, Li J, Wang J, Yue W, Wang L, Liu H, Shi Y, Zhang D
Adv Sci (2023) 10 pp. e2303411-e2303411 [ DOI: doi:10.1002/advs.202303411 Pubmed: 37759382 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 ctf12 (52 kDa, Protein from Homo sapiens)
- Human gamma-secretase treated with ganglioside gm1 (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 7fjn
Q-score: 0.27
Liang Q, Wang Y, Zhang S, Sun J, Sun W, Li J, Liu Y, Li M, Cheng L, Jiang Y, Wang R, Zhang R, Yang Z, Ren Y, Chen P, Gao P, Yan H, Zhang Z, Zhang Q, Shi X, Wang J, Liu W, Wang X, Ying B, Zhao J, Qi H, Zhang L
iScience (2022) 25 pp. 104043-104043 [ Pubmed: 35291264 DOI: doi:10.1016/j.isci.2022.104043 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- S protein of south african (b.1.351) sars-cov-2 (Complex from Homo sapiens)
- T6 light chain (12 kDa, Protein from Homo sapiens)
- T6 heavy chain (12 kDa, Protein from Homo sapiens)
- T6 fab (Complex)
- Spike glycoprotein,envelope glycoprotein (141 kDa, Protein from Human immunodeficiency virus 1)
- S protein of south african (b.1.351) sars-cov-2 spike in complex with t6 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 7fjo
Q-score: 0.106
Liang Q, Wang Y, Zhang S, Sun J, Sun W, Li J, Liu Y, Li M, Cheng L, Jiang Y, Wang R, Zhang R, Yang Z, Ren Y, Chen P, Gao P, Yan H, Zhang Z, Zhang Q, Shi X, Wang J, Liu W, Wang X, Ying B, Zhao J, Qi H, Zhang L
iScience (2022) 25 pp. 104043-104043 [ Pubmed: 35291264 DOI: doi:10.1016/j.isci.2022.104043 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- T6 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- T6 heavy chain (23 kDa, Protein from Homo sapiens)
- T6 light chain (24 kDa, Protein from Homo sapiens)
- S protein of south african (b.1.351) sars-cov-2 spike in complex with t6 fab (Complex from Homo sapiens)
- S protein of south african (b.1.351) sars-cov-2 spike (Complex)
