Cryo-EM structure of human HCAR2-Gi complex without ligand (apo state)
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8ij3
Q-score: 0.506
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of human hcar2-gi complex without ligand (apo state) (Complex from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex with niacin
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8ija
Q-score: 0.574
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Cryo-em structure of human hcar2-gi complex with niacin (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Nicotinic acid (123 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex with acipimox
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8ijb
Q-score: 0.497
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid (155 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of human hcar2-gi complex with acipimox (Complex from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex with MK-6892
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8ijd
Q-score: 0.452
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Cryo-em structure of human hcar2-gi complex with mk-6892 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8ipq
Q-score: 0.332
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8ipr
Q-score: 0.476
Zhu C, Shi Y, Yu J, Zhao W, Li L, Liang J, Yang X, Zhang B, Zhao Y, Gao Y, Chen X, Yang X, Zhang L, Guddat LW, Liu L, Yang H, Rao Z, Li J
Protein Cell (2023) 14 pp. 919-923 [ DOI: doi:10.1093/procel/pwad022 Pubmed: 37144855 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Component linked with the assembly of cytochrome' abc transporter atp-binding protein cydc (51 kDa, Protein from Mycolicibacterium smegmatis)
- Transmembrane atp-binding protein abc transporter cydd (53 kDa, Protein from Mycolicibacterium smegmatis)
- Cyddc (Complex from Mycolicibacterium smegmatis)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8ips
Q-score: 0.472
Zhu C, Shi Y, Yu J, Zhao W, Li L, Liang J, Yang X, Zhang B, Zhao Y, Gao Y, Chen X, Yang X, Zhang L, Guddat LW, Liu L, Yang H, Rao Z, Li J
Protein Cell (2023) 14 pp. 919-923 [ DOI: doi:10.1093/procel/pwad022 Pubmed: 37144855 ]
- Cyddc (Complex from Escherichia coli)
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Abc transporter, cyddc cysteine exporter (cyddc-e) family, permease/atp-binding protein cydc (64 kDa, Protein from Escherichia coli (strain B / BL21-DE3))
- Abc transporter, cyddc cysteine exporter (cyddc-e) family, permease/atp-binding protein cydd (65 kDa, Protein from Escherichia coli (strain B / BL21-DE3))
Cryo-EM structure of heme transporter CydDC from Escherichia coli in the occluded ATP bound state
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8ipt
Q-score: 0.456
Zhu C, Shi Y, Yu J, Zhao W, Li L, Liang J, Yang X, Zhang B, Zhao Y, Gao Y, Chen X, Yang X, Zhang L, Guddat LW, Liu L, Yang H, Rao Z, Li J
Protein Cell (2023) 14 pp. 919-923 [ DOI: doi:10.1093/procel/pwad022 Pubmed: 37144855 ]
- Cyddc (Complex from Escherichia coli)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Abc transporter, cyddc cysteine exporter (cyddc-e) family, permease/atp-binding protein cydd (65 kDa, Protein from Escherichia coli)
- Abc transporter, cyddc cysteine exporter (cyddc-e) family, permease/atp-binding protein cydc (62 kDa, Protein from Escherichia coli)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7bwr
Q-score: 0.419
Zhang L, Zhao Y, Gao R, Li J, Yang X, Gao Y, Zhao W, Gurcha SS, Veerapen N, Batt SM, Besra KK, Xu W, Bi L, Zhang X, Guddat LW, Yang H, Wang Q, Besra GS, Rao Z
Protein Cell (2020) 11 pp. 505-517 [ DOI: doi:10.1007/s13238-020-00726-6 Pubmed: 32363534 ]
- [(2z,6e,10e,14z,18e,22z,26z)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl] [(2s,3s,4s,5r)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl] hydrogen phosphate (911 Da, Ligand)
- Meromycolate extension acyl carrier protein (10 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Mycobacterial arabinosyltransferase complex embb2-acpm2 (254 MDa, Complex from Mycolicibacterium smegmatis MC2 155)
- Integral membrane indolylacetylinositol arabinosyltransferase embb (116 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Calcium ion (40 Da, Ligand)
Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in symmetric "resting state
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7bx8
Q-score: 0.443
Zhang L, Zhao Y, Gao R, Li J, Yang X, Gao Y, Zhao W, Gurcha SS, Veerapen N, Batt SM, Besra KK, Xu W, Bi L, Zhang X, Guddat LW, Yang H, Wang Q, Besra GS, Rao Z
Protein Cell (2020) 11 pp. 505-517 [ DOI: doi:10.1007/s13238-020-00726-6 Pubmed: 32363534 ]
- Mycobacterial arabinosyltransferase complex embb2-acpm2 (254 MDa, Complex from Mycolicibacterium smegmatis MC2 155)
- Integral membrane indolylacetylinositol arabinosyltransferase embb (116 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Meromycolate extension acyl carrier protein (10 kDa, Protein from Mycolicibacterium smegmatis MC2 155)