Cryo-EM Structure of the 3HO-HCAR3-Gi complex
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8jef
Q-score: 0.517
Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y
Cell Rep (2024) 43 pp. 114895-114895 [ DOI: doi:10.1016/j.celrep.2024.114895 Pubmed: 39427321 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- (3s)-3-hydroxyoctanoic acid (160 Da, Ligand)
- Cryo-em structure of the apo hcar3-gi complex (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 3 (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the compuond 5c-HCAR3-Gi complex
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8jei
Q-score: 0.535
Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y
Cell Rep (2024) 43 pp. 114895-114895 [ DOI: doi:10.1016/j.celrep.2024.114895 Pubmed: 39427321 ]
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 3-nitro-4-(propylamino)benzoic acid (224 Da, Ligand)
- Hydroxycarboxylic acid receptor 3 (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of the compound 5c-hcar3-gi complex (Complex from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex without ligand (apo state)
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8ij3
Q-score: 0.506
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of human hcar2-gi complex without ligand (apo state) (Complex from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex with niacin
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8ija
Q-score: 0.574
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Cryo-em structure of human hcar2-gi complex with niacin (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Nicotinic acid (123 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex with acipimox
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8ijb
Q-score: 0.497
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid (155 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of human hcar2-gi complex with acipimox (Complex from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex with MK-6892
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8ijd
Q-score: 0.452
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Cryo-em structure of human hcar2-gi complex with mk-6892 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
Cryo-EM structure of SARS-CoV-2 spike glycoprotein in complex with three F61 Fab
Resolution: 3.62 Å
EM Method: Single-particle
Fitted PDBs: 7xmx
Q-score: -0.013
Li X, Pan Y, Yin Q, Wang Z, Shan S, Zhang L, Yu J, Qu Y, Sun L, Gui F, Lu J, Jing Z, Wu W, Huang T, Shi X, Li J, Li X, Li D, Wang S, Yang M, Zhang L, Duan K, Liang M, Yang X, Wang X
Cell Discov (2022) 8 pp. 87-87 [ DOI: doi:10.1038/s41421-022-00449-4 Pubmed: 36075908 ]
- F61 heavy chain (12 kDa, Protein from Homo sapiens)
- F61 light chain (11 kDa, Protein from Homo sapiens)
- S protein of sars-cov-2 spike in complex with f61 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (143 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 spike glycoprotein in complex with three D2 Fab
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 7xmz
Q-score: 0.384
Li X, Pan Y, Yin Q, Wang Z, Shan S, Zhang L, Yu J, Qu Y, Sun L, Gui F, Lu J, Jing Z, Wu W, Huang T, Shi X, Li J, Li X, Li D, Wang S, Yang M, Zhang L, Duan K, Liang M, Yang X, Wang X
Cell Discov (2022) 8 pp. 87-87 [ DOI: doi:10.1038/s41421-022-00449-4 Pubmed: 36075908 ]
- S protein of sars-cov-2 spike in complex with d2 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (143 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- D2 heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- D2 light chain (11 kDa, Protein from Homo sapiens)
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 7xst
Q-score: 0.299
Li X, Pan Y, Yin Q, Wang Z, Shan S, Zhang L, Yu J, Qu Y, Sun L, Gui F, Lu J, Jing Z, Wu W, Huang T, Shi X, Li J, Li X, Li D, Wang S, Yang M, Zhang L, Duan K, Liang M, Yang X, Wang X
Cell Discov (2022) 8 pp. 87-87 [ DOI: doi:10.1038/s41421-022-00449-4 Pubmed: 36075908 ]
- F61 heavy chain (12 kDa, Protein from Homo sapiens)
- Sars-cov-2 omicron spike in complex with f61 and d2 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- F61 light chain (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (134 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- D2 heavy chain (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- D2 light chain (11 kDa, Protein from Homo sapiens)
