Merbecovirus MOW15-22 Spike glycoprotein RBD bound to the P. davyi ACE2
Ma CB, Liu C, Park YJ, Tang J, Chen J, Xiong Q, Lee J, Stewart C, Asarnow D, Brown J, Tortorici MA, Yang X, Sun YH, Chen YM, Yu X, Si JY, Liu P, Tong F, Huang ML, Li J, Shi ZL, Deng Z, Veesler D, Yan H
Cell (2025) [ Pubmed: 39922191 DOI: doi:10.1016/j.cell.2024.12.031 ]
- Mow15-22 rbd (34 kDa, Protein from Merbecovirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pteronotus davyi ace2 ectodomain (89 kDa, Protein from Pteronotus davyi)
- Mow15-22 rbd bound to the p. davyi ace2 ectodomain (Complex from Sarbecovirus)
Merbecovirus PnNL2018B Spike glycoprotein RBD bound to the P. Nathusii ACE2
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9dak
Q-score: 0.632
Ma CB, Liu C, Park YJ, Tang J, Chen J, Xiong Q, Lee J, Stewart C, Asarnow D, Brown J, Tortorici MA, Yang X, Sun YH, Chen YM, Yu X, Si JY, Liu P, Tong F, Huang ML, Li J, Shi ZL, Deng Z, Veesler D, Yan H
Cell (2025) [ DOI: doi:10.1016/j.cell.2024.12.031 Pubmed: 39922191 ]
- Ace2 (102 kDa, Protein from Pipistrellus nathusii)
- Water (18 Da, Ligand)
- Merbecovirus pnnl2018b spike glycoprotein rbd bound to the p. nathusii ace2 (Complex from Merbecovirus)
- Spike glycoprotein receptor binding domain (34 kDa, Protein from Merbecovirus)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of P.nat ACE2 mutant in complex with MOW15-22 RBD
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8zuf
Q-score: 0.457
Ma CB, Liu C, Park YJ, Tang J, Chen J, Xiong Q, Lee J, Stewart C, Asarnow D, Brown J, Tortorici MA, Yang X, Sun YH, Chen YM, Yu X, Si JY, Liu P, Tong F, Huang ML, Li J, Shi ZL, Deng Z, Veesler D, Yan H
Cell (2025) [ DOI: doi:10.1016/j.cell.2024.12.031 Pubmed: 39922191 ]
- Zinc ion (65 Da, Ligand)
- Angiotensin-converting enzyme (90 kDa, Protein from Pipistrellus nathusii)
- P.nat ace2-mow15-22 rbd (Complex from Pipistrellus nathusii)
- Mow15-22 rbd (23 kDa, Protein from Middle East respiratory syndrome-related coronavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8xau
Q-score: 0.477
An Q, Wang Y, Tian Z, Han J, Li J, Liao F, Yu F, Zhao H, Wen Y, Zhang H, Deng Z
Cell Res (2024) 34 pp. 545-555 [ Pubmed: 38834762 DOI: doi:10.1038/s41422-024-00981-w ]
- Hera (Complex from Escherichia coli)
- Atp-binding protein (64 kDa, Protein from Escherichia coli)
Cryo-EM structure of an anti-phage defense complex
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 8xav
Q-score: 0.535
An Q, Wang Y, Tian Z, Han J, Li J, Liao F, Yu F, Zhao H, Wen Y, Zhang H, Deng Z
Cell Res (2024) 34 pp. 545-555 [ Pubmed: 38834762 DOI: doi:10.1038/s41422-024-00981-w ]
- Duf4297 (46 kDa, Protein from Escherichia coli)
- Duf4297-hera (Complex from Escherichia coli)
- Atp-binding protein (64 kDa, Protein from Escherichia coli)
Cryo-EM structure of an anti-phage defense complex bound to AMPPNP and DNA at state 1
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8xaw
Q-score: 0.553
An Q, Wang Y, Tian Z, Han J, Li J, Liao F, Yu F, Zhao H, Wen Y, Zhang H, Deng Z
Cell Res (2024) 34 pp. 545-555 [ Pubmed: 38834762 DOI: doi:10.1038/s41422-024-00981-w ]
- Magnesium ion (24 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- S20dna1 (18 kDa, DNA from Escherichia coli)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- S20dna2 (18 kDa, DNA from Escherichia coli)
- Atp-binding protein (64 kDa, Protein from Escherichia coli)
- Duf4297 (46 kDa, Protein from Escherichia coli)
- Duf4297-hera-dna-state2 (Complex from Escherichia coli)
Cryo-EM structure of an anti-phage defense complex bound to AMPPNP and DNA at state 2
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8xax
Q-score: 0.516
An Q, Wang Y, Tian Z, Han J, Li J, Liao F, Yu F, Zhao H, Wen Y, Zhang H, Deng Z
Cell Res (2024) 34 pp. 545-555 [ Pubmed: 38834762 DOI: doi:10.1038/s41422-024-00981-w ]
- Magnesium ion (24 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Duf4297-hera-dna state1 (Complex from Escherichia coli)
- S20dna1 (18 kDa, DNA from Escherichia coli)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- S20dna2 (18 kDa, DNA from Escherichia coli)
- Atp-binding protein (64 kDa, Protein from Escherichia coli)
- Duf4297 (46 kDa, Protein from Escherichia coli)
Cryo-EM structure of an anti-phage defense complex bound to ATPrS and DNA
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 8xay
Q-score: 0.55
An Q, Wang Y, Tian Z, Han J, Li J, Liao F, Yu F, Zhao H, Wen Y, Zhang H, Deng Z
Cell Res (2024) 34 pp. 545-555 [ Pubmed: 38834762 DOI: doi:10.1038/s41422-024-00981-w ]
- Magnesium ion (24 Da, Ligand)
- Phosphothiophosphoric acid-adenylate ester (523 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- S20dna3 (18 kDa, Macromolecule from Escherichia coli)
- Atp-binding protein (64 kDa, Protein from Escherichia coli)
- Duf4297 (46 kDa, Protein from Escherichia coli)
- Duf4297-hera (Complex from Escherichia coli)
- S20dna4 (18 kDa, DNA from Escherichia coli)
Resolution: 4.26 Å
EM Method: Single-particle
Fitted PDBs: 8h8d
Q-score: 0.332
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 8h8e
Q-score: 0.368