CCHFV GP38 bound with ADI-46143 and ADI-46158 Fabs
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Cell Rep (2024) 43 pp. 114502-114502 [ DOI: doi:10.1016/j.celrep.2024.114502 Pubmed: 39002130 ]
- Cchfv gp38 (Protein from Crimean-Congo hemorrhagic fever virus)
- Cchfv gp38 (Complex from Crimean-Congo hemorrhagic fever virus)
- Adi-46158 fab light chain (Protein from Homo sapiens)
- Adi-46158 fab heavy chain (Protein from Homo sapiens)
- Adi-46143 fab (Complex from Homo sapiens)
- Adi-46143 fab heavy chain (Protein from Homo sapiens)
- Adi-46143 fab light chain (Protein from Homo sapiens)
- Cchfv gp38 bound with adi-46143 fab and adi-46158 fab (Complex)
- Adi-46158 fab (Complex from Homo sapiens)
CCHFV GP38 bound with ADI-58062 and ADI-63530 Fabs
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Cell Rep (2024) 43 pp. 114502-114502 [ DOI: doi:10.1016/j.celrep.2024.114502 Pubmed: 39002130 ]
- Adi-58062 fab (Complex from Homo sapiens)
- Cchfv gp38 (Protein from Crimean-Congo hemorrhagic fever virus)
- Cchfv gp38 (Complex from Crimean-Congo hemorrhagic fever virus)
- Adi-63530 fab heavy chain (Protein from Homo sapiens)
- Adi-63530 fab (Complex from Homo sapiens)
- Adi-63530 fab light chain (Protein from Homo sapiens)
- Cchfv gp38 bound with adi-58062 fab and adi-63530 fab (Complex)
- Adi-58062 fab light chain (Protein from Homo sapiens)
- Adi-58062 fab heavy chain (Protein from Homo sapiens)
CCHFV GP38 bound with ADI-58026 and ADI-63547 Fabs
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Cell Rep (2024) 43 pp. 114502-114502 [ DOI: doi:10.1016/j.celrep.2024.114502 Pubmed: 39002130 ]
- Cchfv gp38 bound with adi-58026 fab and adi-63547 fab (Complex)
- Adi-58026 fab (Complex from Homo sapiens)
- Cchfv gp38 (Protein from Crimean-Congo hemorrhagic fever virus)
- Cchfv gp38 (Complex from Crimean-Congo hemorrhagic fever virus)
- Adi-63547 fab (Complex from Homo sapiens)
- Adi-58026 fab heavy chain (Protein from Homo sapiens)
- Adi-63547 fab heavy chain (Protein from Homo sapiens)
- Adi-58026 fab light chain (Protein from Homo sapiens)
- Adi-63547 fab light chain (Protein from Homo sapiens)
CCHFV GP38 bound to ADI-46152 and ADI-58048 Fabs
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8vww
Q-score: 0.412
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Cell Rep (2024) 43 pp. 114502-114502 [ DOI: doi:10.1016/j.celrep.2024.114502 Pubmed: 39002130 ]
- Gp38 (30 kDa, Protein from Crimean-Congo hemorrhagic fever virus strain IbAr10200)
- Adi-58048 fab (Complex from Homo sapiens)
- Cchfv gp38 (Complex from Crimean-Congo hemorrhagic fever virus)
- Adi-58048 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Cchfv gp38 bound with adi-46152 and adi-58048 fabs (Complex)
- Adi-46152 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Adi-58048 fab light chain (23 kDa, Protein from Homo sapiens)
- Adi-46152 fab (Complex from Homo sapiens)
- Adi-46152 fab light chain (22 kDa, Protein from Homo sapiens)
Atomic model of the mammalian mouse Mediator complex with CKM module
Resolution: 4.83 Å
EM Method: Single-particle
Fitted PDBs: 8t1l
Q-score: 0.247
Zhao H, Li J, Xiang Y, Malik S, Vartak SV, Veronezi GMB, Young N, Riney M, Kalchschmidt J, Conte A, Jung SK, Ramachandran S, Roeder RG, Shi Y, Casellas R, Asturias FJ
Mol Cell (2024) 84 pp. 2648-2664.e10 [ Pubmed: 38955181 DOI: doi:10.1016/j.molcel.2024.06.006 ]
- Mouse mediator complex (1 MDa, Complex from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 11 (13 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 31 (15 kDa, Protein from Mus musculus)
- Unknown (1 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 21 (15 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 23 (156 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 1 (167 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 8 (29 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 9 (15 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 30 (20 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 14 (161 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 13 (238 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 27 (35 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 29 (21 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 24 (110 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 10 (15 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 22 (22 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 17 (72 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 4 (29 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 28 (19 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 20 (23 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 18 (23 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 25 (78 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 15 (86 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 16 (91 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 6 (28 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 7 (27 kDa, Protein from Mus musculus)
Resolution: 4.66 Å
EM Method: Single-particle
Fitted PDBs: 8t9d
Q-score: 0.215
Zhao H, Li J, Xiang Y, Malik S, Vartak SV, Veronezi GMB, Young N, Riney M, Kalchschmidt J, Conte A, Jung SK, Ramachandran S, Roeder RG, Shi Y, Casellas R, Asturias FJ
Mol Cell (2024) 84 pp. 2648-2664.e10 [ Pubmed: 38955181 DOI: doi:10.1016/j.molcel.2024.06.006 ]
- Mediator of rna polymerase ii transcription subunit 8 (29 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 10 (15 kDa, Protein from Homo sapiens)
- Unknown peptide (1 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 21 (15 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 23 (156 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 16 (96 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 25 (78 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 14 (160 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 30 (20 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 4 (29 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 29 (21 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 9 (16 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 1 (168 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 20 (23 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 24 (110 kDa, Protein from Homo sapiens)
- Mediator complex with transcription factor tr (Complex from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 7 (27 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 15 (86 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 28 (19 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 11 (13 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 22 (22 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 18 (23 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 31 (15 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 27 (35 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 13 (239 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 6 (28 kDa, Protein from Homo sapiens)
- Mediator of rna polymerase ii transcription subunit 17 (72 kDa, Protein from Homo sapiens)
Atomic model of the mammalian Mediator complex with MED26 subunit
Resolution: 4.68 Å
EM Method: Single-particle
Fitted PDBs: 8t1i
Q-score: 0.238
Zhao H, Li J, Xiang Y, Malik S, Vartak SV, Veronezi GMB, Young N, Riney M, Kalchschmidt J, Conte A, Jung SK, Ramachandran S, Roeder RG, Shi Y, Casellas R, Asturias FJ
Mol Cell (2024) 84 pp. 2648-2664.e10 [ Pubmed: 38955181 DOI: doi:10.1016/j.molcel.2024.06.006 ]
- Mouse mediator complex (1 MDa, Complex from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 11 (13 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 31 (15 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 21 (15 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 23 (156 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 1 (167 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 8 (29 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 9 (15 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 30 (20 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 14 (161 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 27 (35 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 29 (21 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 24 (110 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 10 (15 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 22 (22 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 17 (72 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 26 (64 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 4 (29 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 28 (19 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 20 (23 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 18 (23 kDa, Protein from Mus musculus)
- Unknown peptide (1 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 25 (78 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 15 (86 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 16 (91 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 6 (28 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 7 (27 kDa, Protein from Mus musculus)
- Mediator of rna polymerase ii transcription subunit 19 (25 kDa, Protein from Mus musculus)
Resolution: 3.71 Å
EM Method: Single-particle
Fitted PDBs: 8q7r
Q-score: 0.324
Li J, Purser N, Liwocha J, Scott DC, Byers HA, Steigenberger B, Hill S, Tripathi-Giesgen I, Hinkle T, Hansen FM, Prabu JR, Radhakrishnan SK, Kirkpatrick DS, Reichermeier KM, Schulman BA, Kleiger G
Mol Cell (2024) 84 pp. 1304- [ DOI: doi:10.1016/j.molcel.2024.01.022 Pubmed: 38382526 ]
- Ring e3 ligase (rbx1) and cullin-2 (cul2) (Complex from Homo sapiens)
- Ubiquitin ligation to substrate by a cullin-ring e3 ligase & cdc34: nedd8-cul2-rbx1-elob/c-fem1c with trapped ube2r2~donor ub-sil1 peptide (180 kDa, Complex)
- Cdc34, nedd8, elob, eloc, fem1c with ube2r2-donor ub-sil1 peptide (Complex from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Ubiquitin (77 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (12 kDa, Protein from Homo sapiens)
- Nucleotide exchange factor sil1 (2 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Protein fem-1 homolog c (68 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- 5-azanyl-1-oxidanyl-pentan-2-one (117 Da, Ligand)
- Ubiquitin-conjugating enzyme e2 r2 (27 kDa, Protein from Homo sapiens)
Resolution: 3.44 Å
EM Method: Single-particle
Fitted PDBs: 8r5h
Q-score: 0.394
Li J, Purser N, Liwocha J, Scott DC, Byers HA, Steigenberger B, Hill S, Tripathi-Giesgen I, Hinkle T, Hansen FM, Prabu JR, Radhakrishnan SK, Kirkpatrick DS, Reichermeier KM, Schulman BA, Kleiger G
Mol Cell (2024) 84 pp. 1304- [ DOI: doi:10.1016/j.molcel.2024.01.022 Pubmed: 38382526 ]
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- 5-azanylpentan-2-one (101 Da, Ligand)
- Ring e3 ligase (rbx1) and cullin-2 (cul2) (Complex from Homo sapiens)
- Bromodomain-containing protein 4 (13 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Ubiquitin-conjugating enzyme e2 r2 (25 kDa, Protein from Homo sapiens)
- Ubiquitin ligation to neosubstrate by a cullin-ring e3 ligase and cdc34: nedd8-cul2-rbx1-elob/c-vhl-mz1 with trapped ube2r2~donor ub-brd4 bd2 (190 kDa, Complex from Homo sapiens)
- Von hippel-lindau disease tumor suppressor (18 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (11 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- (2~{s},4~{r})-1-[(2~{s})-2-[2-[2-[2-[2-[2-[(9~{s})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethanoylamino]-3,3-dimethyl-butanoyl]-~{n}-[[4-(4-methyl-2,3-dihydro-1,3-thiazol-5-yl)phenyl]methyl]-4-oxidanyl-pyrrolidine-2-carboxamide (1 kDa, Ligand)
- Cdc34, nedd8, elob, eloc, vhl, brd4 with ube2r2-donor ub- brd4 bd2 (Complex from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA)
Resolution: 2.59 Å
EM Method: Single-particle
Fitted PDBs: 7w1y
Q-score: 0.595
Li J, Dong J, Wang W, Yu D, Fan X, Hui YC, Lee CSK, Lam WH, Alary N, Yang Y, Zhang Y, Zhao Q, Chen CL, Tye BK, Dang S, Zhai Y
Cell (2023) 186 pp. 98-111.e21 [ Pubmed: 36608662 DOI: doi:10.1016/j.cell.2022.12.008 ]
- Dna replication licensing factor mcm5 (82 kDa, Protein from Homo sapiens)
- Dna (49-mer) (14 kDa, DNA from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Isoform 2 of dna replication licensing factor mcm3 (96 kDa, Protein from Homo sapiens)
- Dna replication licensing factor mcm6 (93 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Dna replication licensing factor mcm4 (96 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Human mini-chromosome maintenance complex (1 MDa, Complex from Homo sapiens)
- Dna replication licensing factor mcm7 (81 kDa, Protein from Homo sapiens)
- Dna (49-mer) (15 kDa, DNA from Homo sapiens)
- Dna replication licensing factor mcm2 (102 kDa, Protein from Homo sapiens)
- Dna (Complex)
- Dna replication licensing factor mcm 2/3/4/5/6/7 (Complex from Homo sapiens)