Cryo-EM Structure of the 3HO-HCAR3-Gi complex
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8jef
Q-score: 0.517
Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y
Cell Rep (2024) 43 pp. 114895-114895 [ Pubmed: 39427321 DOI: doi:10.1016/j.celrep.2024.114895 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the apo hcar3-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 3 (44 kDa, Protein from Homo sapiens)
- (3s)-3-hydroxyoctanoic acid (160 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the compuond 5c-HCAR3-Gi complex
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8jei
Q-score: 0.535
Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y
Cell Rep (2024) 43 pp. 114895-114895 [ Pubmed: 39427321 DOI: doi:10.1016/j.celrep.2024.114895 ]
- Cryo-em structure of the compound 5c-hcar3-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 3 (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- 3-nitro-4-(propylamino)benzoic acid (224 Da, Ligand)
Cryo-EM structure of human HCAR2-Gi complex without ligand (apo state)
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8ij3
Q-score: 0.506
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of human hcar2-gi complex without ligand (apo state) (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex with niacin
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8ija
Q-score: 0.574
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Nicotinic acid (123 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of human hcar2-gi complex with niacin (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex with acipimox
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8ijb
Q-score: 0.497
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Cryo-em structure of human hcar2-gi complex with acipimox (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid (155 Da, Ligand)
Cryo-EM structure of human HCAR2-Gi complex with MK-6892
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8ijd
Q-score: 0.452
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Cryo-em structure of human hcar2-gi complex with mk-6892 (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Cryo-EM structure of TMEM16F in digitonin with calcium bound
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 6p46
Q-score: 0.403
Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y
Cell Rep (2019) 28 pp. 567-579.e4 [ DOI: doi:10.1016/j.celrep.2019.06.023 Pubmed: 31291589 ]
- Anoctamin-6 (106 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- Tmem16f with calcium bound (Complex from Mus musculus)
Cryo-EM structure of TMEM16F in digitonin without calcium
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6p47
Q-score: 0.365
Feng S, Dang S, Han TW, Ye W, Jin P, Cheng T, Li J, Jan YN, Jan LY, Cheng Y
Cell Rep (2019) 28 pp. 567-579.e4 [ DOI: doi:10.1016/j.celrep.2019.06.023 Pubmed: 31291589 ]
- Tmem16f without calcium bound (Complex from Mus musculus)
- Anoctamin-6 (106 kDa, Protein from Mus musculus)