Rat Kir4.1 in complex with PIP2
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8i5m
Q-score: 0.486
Zhou X, Zhao C, Xu H, Xu Y, Zhan L, Wang P, He J, Lu T, Gu Y, Yang Y, Xu C, Chen Y, Liu Y, Zeng Y, Tian F, Chen Q, Xie X, Liu J, Hu H, Li J, Zheng Y, Guo J, Gao Z
Nat Chem Biol (2024) 20 pp. 857-866 [ DOI: doi:10.1038/s41589-024-01555-y Pubmed: 38355723 ]
- Rat kir4.1 in complex with pip2 (Complex from Rattus norvegicus)
- Atp-sensitive inward rectifier potassium channel 10 (38 kDa, Protein from Rattus norvegicus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
Rat Kir4.1 in complex with PIP2 and Lys05
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8i5n
Q-score: 0.414
Zhou X, Zhao C, Xu H, Xu Y, Zhan L, Wang P, He J, Lu T, Gu Y, Yang Y, Xu C, Chen Y, Liu Y, Zeng Y, Tian F, Chen Q, Xie X, Liu J, Hu H, Li J, Zheng Y, Guo J, Gao Z
Nat Chem Biol (2024) 20 pp. 857-866 [ DOI: doi:10.1038/s41589-024-01555-y Pubmed: 38355723 ]
- Atp-sensitive inward rectifier potassium channel 10 (38 kDa, Protein from Rattus norvegicus)
- Rat kir4.1 in complex with pip2 and lys05 (Complex from Rattus norvegicus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8sun
Q-score: 0.43
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ Pubmed: 37573365 DOI: doi:10.1038/s41467-023-40410-x ]
- Anoctamin-6 (95 kDa, Protein from Mus musculus)
- 16f (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1-hydroxy-3-(trifluoromethyl)pyrido[1,2-a]benzimidazole-4-carbonitrile (277 Da, Ligand)
TMEM16F bound with Niclosamide
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8sur
Q-score: 0.46
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ Pubmed: 37573365 DOI: doi:10.1038/s41467-023-40410-x ]
- Anoctamin-6 (106 kDa, Protein from Mus musculus)
- 5-chloro-n-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide (327 Da, Ligand)
- 16f (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
TMEM16F, with Calcium and PIP2, no inhibitor
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8tag
Q-score: 0.452
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ Pubmed: 37573365 DOI: doi:10.1038/s41467-023-40410-x ]
- 16f (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anoctamin-6 (95 kDa, Protein from Mus musculus)
TMEM16F, with Calcium and PIP2, no inhibitor, Cl2
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8tai
Q-score: 0.466
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ Pubmed: 37573365 DOI: doi:10.1038/s41467-023-40410-x ]
- 16f (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anoctamin-6 (95 kDa, Protein from Mus musculus)
TMEM16F, with Calcium and PIP2, no inhibitor, Cl1
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8tal
Q-score: 0.454
Feng S, Puchades C, Ko J, Wu H, Chen Y, Figueroa EE, Gu S, Han TW, Ho B, Cheng T, Li J, Shoichet B, Jan YN, Cheng Y, Jan LY
Nat Commun (2023) 14 pp. 4874-4874 [ Pubmed: 37573365 DOI: doi:10.1038/s41467-023-40410-x ]
- 16f (Complex from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Anoctamin-6 (95 kDa, Protein from Mus musculus)
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 7yhk
Q-score: 0.556
Li T, Chen J, Zheng Q, Xue W, Zhang L, Rong R, Zhang S, Wang Q, Hong M, Zhang Y, Cui L, He M, Lu Z, Zhang Z, Chi X, Li J, Huang Y, Wang H, Tang J, Ying D, Zhou L, Wang Y, Yu H, Zhang J, Gu Y, Chen Y, Li S, Xia N
Nat Commun (2022) 13 pp. 5182-5182 [ Pubmed: 36056024 DOI: doi:10.1038/s41467-022-32926-5 ]
- Neutralizing antibody 12h5 (Complex from Mus musculus)
- Hemagglutinin (62 kDa, Protein from Influenza A virus (A/Beijing/262/1995(H1N1)))
- Ha trimer of a/beijing/262/1995(h1n1) (Complex from Influenza A virus (A/Beijing/262/1995(H1N1)))
- 12h5 heavy chain (12 kDa, Protein from Mus musculus)
- 12h5 light chain (12 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of the ha trimer of a/beijing/262/1995(h1n1) in complex with neutralizing antibody 12h5 (Complex)