BA.2.86 RBD protein in complex with ACE2.
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8yzb
Q-score: 0.477
Liu Y, Zhao X, Shi J, Wang Y, Liu H, Hu YF, Hu B, Shuai H, Yuen TT, Chai Y, Liu F, Gong HR, Li J, Wang X, Jiang S, Zhang X, Zhang Y, Li X, Wang L, Hartnoll M, Zhu T, Hou Y, Huang X, Yoon C, Wang Y, He Y, Zhou M, Du L, Zhang X, Chan WM, Chen LL, Cai JP, Yuan S, Zhou J, Huang JD, Yuen KY, To KK, Chan JF, Zhang BZ, Sun L, Wang P, Chu H
Nat Commun (2024) 15 pp. 8728-8728 [ Pubmed: 39379369 DOI: doi:10.1038/s41467-024-53033-7 ]
- Spike glycoprotein,fibritin,fusion protein (142 kDa, Protein from synthetic construct)
- Ba.2.86 rbd protein in complex with ace2 (Complex from Homo sapiens)
- Angiotensin-converting enzyme 2 (85 kDa, Protein from Homo sapiens)
Structure of BA.2.86 spike protein in complex with ACE2.
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8yzc
Q-score: 0.267
Liu Y, Zhao X, Shi J, Wang Y, Liu H, Hu YF, Hu B, Shuai H, Yuen TT, Chai Y, Liu F, Gong HR, Li J, Wang X, Jiang S, Zhang X, Zhang Y, Li X, Wang L, Hartnoll M, Zhu T, Hou Y, Huang X, Yoon C, Wang Y, He Y, Zhou M, Du L, Zhang X, Chan WM, Chen LL, Cai JP, Yuan S, Zhou J, Huang JD, Yuen KY, To KK, Chan JF, Zhang BZ, Sun L, Wang P, Chu H
Nat Commun (2024) 15 pp. 8728-8728 [ Pubmed: 39379369 DOI: doi:10.1038/s41467-024-53033-7 ]
Structure of JN.1 RBD protein in complex with ACE2.
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8yzd
Q-score: 0.573
Liu Y, Zhao X, Shi J, Wang Y, Liu H, Hu YF, Hu B, Shuai H, Yuen TT, Chai Y, Liu F, Gong HR, Li J, Wang X, Jiang S, Zhang X, Zhang Y, Li X, Wang L, Hartnoll M, Zhu T, Hou Y, Huang X, Yoon C, Wang Y, He Y, Zhou M, Du L, Zhang X, Chan WM, Chen LL, Cai JP, Yuan S, Zhou J, Huang JD, Yuen KY, To KK, Chan JF, Zhang BZ, Sun L, Wang P, Chu H
Nat Commun (2024) 15 pp. 8728-8728 [ Pubmed: 39379369 DOI: doi:10.1038/s41467-024-53033-7 ]
The JN.1 spike protein (S) in complex with ACE2.
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8yze
Q-score: 0.25
Liu Y, Zhao X, Shi J, Wang Y, Liu H, Hu YF, Hu B, Shuai H, Yuen TT, Chai Y, Liu F, Gong HR, Li J, Wang X, Jiang S, Zhang X, Zhang Y, Li X, Wang L, Hartnoll M, Zhu T, Hou Y, Huang X, Yoon C, Wang Y, He Y, Zhou M, Du L, Zhang X, Chan WM, Chen LL, Cai JP, Yuan S, Zhou J, Huang JD, Yuen KY, To KK, Chan JF, Zhang BZ, Sun L, Wang P, Chu H
Nat Commun (2024) 15 pp. 8728-8728 [ Pubmed: 39379369 DOI: doi:10.1038/s41467-024-53033-7 ]
Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Tamsulosin (408 Da, Ligand)
- Hexane (86 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
Rat Kir4.1 in complex with PIP2
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8i5m
Q-score: 0.486
Zhou X, Zhao C, Xu H, Xu Y, Zhan L, Wang P, He J, Lu T, Gu Y, Yang Y, Xu C, Chen Y, Liu Y, Zeng Y, Tian F, Chen Q, Xie X, Liu J, Hu H, Li J, Zheng Y, Guo J, Gao Z
Nat Chem Biol (2024) 20 pp. 857-866 [ DOI: doi:10.1038/s41589-024-01555-y Pubmed: 38355723 ]
- Rat kir4.1 in complex with pip2 (Complex from Rattus norvegicus)
- Atp-sensitive inward rectifier potassium channel 10 (38 kDa, Protein from Rattus norvegicus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
Rat Kir4.1 in complex with PIP2 and Lys05
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8i5n
Q-score: 0.414
Zhou X, Zhao C, Xu H, Xu Y, Zhan L, Wang P, He J, Lu T, Gu Y, Yang Y, Xu C, Chen Y, Liu Y, Zeng Y, Tian F, Chen Q, Xie X, Liu J, Hu H, Li J, Zheng Y, Guo J, Gao Z
Nat Chem Biol (2024) 20 pp. 857-866 [ DOI: doi:10.1038/s41589-024-01555-y Pubmed: 38355723 ]
- Atp-sensitive inward rectifier potassium channel 10 (38 kDa, Protein from Rattus norvegicus)
- Rat kir4.1 in complex with pip2 and lys05 (Complex from Rattus norvegicus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 1
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8jpb
Q-score: 0.448
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE
Nature (2023) 620 pp. 676-681 [ Pubmed: 37532940 DOI: doi:10.1038/s41586-023-06395-9 ]
- Neurotensin receptor type 1 (46 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Nts(8-13) (819 Da, Protein from synthetic construct)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol (450 Da, Ligand)
- Staurosporine (466 Da, Ligand)
- Beta-adrenergic receptor kinase 1 (79 kDa, Protein from Bos taurus)
- Ntsr1-grk2-galpha(q) complexes 1 (Complex from Homo sapiens)
cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 2
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8jpc
Q-score: 0.458
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE
Nature (2023) 620 pp. 676-681 [ Pubmed: 37532940 DOI: doi:10.1038/s41586-023-06395-9 ]
- Neurotensin receptor type 1 (46 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Nts(8-13) (819 Da, Protein from synthetic construct)
- Ntsr1-grk2-galpha(q) complexes 2 (Complex from Homo sapiens)
- Tetrafluoroaluminate ion (102 Da, Ligand)
- 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol (450 Da, Ligand)
- Staurosporine (466 Da, Ligand)
- Beta-adrenergic receptor kinase 1 (79 kDa, Protein from Bos taurus)
Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 8jpd
Q-score: 0.497
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE
Nature (2023) 620 pp. 676-681 [ Pubmed: 37532940 DOI: doi:10.1038/s41586-023-06395-9 ]
- Staurosporine (466 Da, Ligand)
- Beta-adrenergic receptor kinase 1 (79 kDa, Protein from Bos taurus)
- Focused refinement structure of grk2 in ntsr1-grk2-galpha(q) complexes (Complex from Bos taurus)