cryo-EM structure of human Cereblon/DDB1 in complex with a non-traditional CRBN binder
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9dqd
Q-score: 0.467
Lejava A, Miseo GA, Phan T, Zhu J, Powers HL, Li J, Mortensen DS, Zapf CW, Khambatta G, Buenviaje J, Holmberg-Douglas N
Acs Med.Chem.Lett. (2025) 16 pp. 89-95 [ Pubmed: 39811117 DOI: doi:10.1021/acsmedchemlett.4c00462 ]
- Protein cereblon (53 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Crebn-ddb1 plus a non-traditional crbn binder (Complex from Homo sapiens)
- (3r)-3-{1-methyl-6-[(piperidin-4-yl)amino]-1h-indazol-3-yl}piperidine-2,6-dione (341 Da, Ligand)
- Dna damage-binding protein 1 (93 kDa, Protein from Homo sapiens)
Cryo-EM structure of IMPDH2 bound to IMP and GAD
Resolution: 1.82 Å
EM Method: Single-particle
Fitted PDBs: 9dmu
Q-score: 0.802
Chen YJ, Iyer SV, Hsieh DC, Li B, Elias HK, Wang T, Li J, Ganbold M, Lien MC, Peng YC, Xie XP, Jayewickreme CD, van den Brink MRM, Brady SF, Lim SK, Parada LF
Nature (2024) 636 pp. 466-473 [ Pubmed: 39567689 DOI: doi:10.1038/s41586-024-08224-z ]
- Ternary complex of impdh2 bound to imp and gad (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Inosine-5'-monophosphate dehydrogenase 2 (56 kDa, Protein from Homo sapiens)
- [[(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{r},3~{s},4~{r},5~{r})-3,4-bis(oxidanyl)-5-[3-(thiophen-2-ylcarbonylamino)pyridin-1-yl]oxolan-2-yl]methyl hydrogen phosphate (746 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Inosinic acid (348 Da, Ligand)
Cryo-EM structure of human HCN3 channel with cAMP
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8io0
Q-score: 0.42
Structure of the semi-extended AlphaIIbBeta3 in complex with R21D10 Fab
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9axl
Q-score: 0.473
Wang L, Wang J, Li J, Walz T, Coller BS
Blood Adv (2024) 8 pp. 4398-4409 [ DOI: doi:10.1182/bloodadvances.2024013177 Pubmed: 38968144 ]
- Magnesium ion (24 Da, Ligand)
- Integrin beta-3 (87 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- The semi-extended alphaiibbeta3 in complex with r21d10 fab (250 kDa, Complex)
- Integrin alpha-iib (113 kDa, Protein from Homo sapiens)
- R21d10 fab heavy chain (24 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- R21d10 fab light chain (23 kDa, Protein from Mus musculus)
The map of the bent AlphaIIbBeta3 in complex with R21D10 Fab
Wang L, Wang J, Li J, Walz T, Coller BS
Blood Adv (2024) 8 pp. 4398-4409 [ DOI: doi:10.1182/bloodadvances.2024013177 Pubmed: 38968144 ]
- R21d10 fab heavy chain (Protein from Mus musculus)
- Alphaiibbeta3 integrin (Complex from Homo sapiens)
- R21d10 fab (Complex from Mus musculus)
- The semi-extended alphaiibbeta3 in complex with r21d10 fab (250 kDa, Complex)
- Integrin beta3 (Protein from Homo sapiens)
- R211010 fab light chain (Protein from Mus musculus)
- Integrin alphaiib (Protein from Homo sapiens)
State 2 of SARS-CoV-2 XBB Variant Spike protein trimer complexed with antibody PW5-5
Zhao X, Qiu T, Huang X, Mao Q, Wang Y, Qiao R, Li J, Mao T, Wang Y, Cun Y, Wang C, Luo C, Yoon C, Wang X, Li C, Cui Y, Zhao C, Li M, Chen Y, Cai G, Geng W, Hu Z, Cao J, Zhang W, Cao Z, Chu H, Sun L, Wang P
Cell Discov (2024) 10 pp. 14-14 [ Pubmed: 38320990 DOI: doi:10.1038/s41421-024-00648-1 ]
- Pw5-5 light chain (23 kDa, Protein from Homo sapiens)
- Sars spike protein (s) in complex with broadly neutralizing antibody pw5-5 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Pw5-5 heavy chain (49 kDa, Protein from Homo sapiens)
- Spike glycoprotein (143 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Structure of SARS-CoV Spike protein complexed with antibody PW5-5
Zhao X, Qiu T, Huang X, Mao Q, Wang Y, Qiao R, Li J, Mao T, Wang Y, Cun Y, Wang C, Luo C, Yoon C, Wang X, Li C, Cui Y, Zhao C, Li M, Chen Y, Cai G, Geng W, Hu Z, Cao J, Zhang W, Cao Z, Chu H, Sun L, Wang P
Cell Discov (2024) 10 pp. 14-14 [ Pubmed: 38320990 DOI: doi:10.1038/s41421-024-00648-1 ]
- Spike glycoprotein (131 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars spike protein (s) in complex with broadly neutralizing antibody pw5-5 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Pw5-5 heavy chain (49 kDa, Protein from Homo sapiens)
- Pw5-5 light chain (23 kDa, Protein from Homo sapiens)
The local refined map of SARS-CoV-2 XBB Variant Spike protein complexed with antibody PW5-535
Zhao X, Qiu T, Huang X, Mao Q, Wang Y, Qiao R, Li J, Mao T, Wang Y, Cun Y, Wang C, Luo C, Yoon C, Wang X, Li C, Cui Y, Zhao C, Li M, Chen Y, Cai G, Geng W, Hu Z, Cao J, Zhang W, Cao Z, Chu H, Sun L, Wang P
Cell Discov (2024) 10 pp. 14-14 [ Pubmed: 38320990 DOI: doi:10.1038/s41421-024-00648-1 ]
- Spike glycoprotein (143 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Xbb spike protein (s) in complex with broadly neutralizing antibody pw5-5353 (Complex from Homo sapiens)
- Pw5-535 light chain (23 kDa, Protein from Homo sapiens)
- Pw5-535 heavy chain (49 kDa, Protein from Homo sapiens)
Trimer state of SARS-CoV Spike protein complexed with antibody PW5-535
Zhao X, Qiu T, Huang X, Mao Q, Wang Y, Qiao R, Li J, Mao T, Wang Y, Cun Y, Wang C, Luo C, Yoon C, Wang X, Li C, Cui Y, Zhao C, Li M, Chen Y, Cai G, Geng W, Hu Z, Cao J, Zhang W, Cao Z, Chu H, Sun L, Wang P
Cell Discov (2024) 10 pp. 14-14 [ Pubmed: 38320990 DOI: doi:10.1038/s41421-024-00648-1 ]
- Pw5-535 light chain (23 kDa, Protein from Homo sapiens)
- Sars spike protein (s) in complex with broadly neutralizing antibody pw5-535 (Complex from Homo sapiens)
- Pw5-535 heavy chain (49 kDa, Protein from Homo sapiens)
- Spike glycoprotein (131 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
The local refined map of SARS-CoV Spike protein complexed with antibody PW5-5
Zhao X, Qiu T, Huang X, Mao Q, Wang Y, Qiao R, Li J, Mao T, Wang Y, Cun Y, Wang C, Luo C, Yoon C, Wang X, Li C, Cui Y, Zhao C, Li M, Chen Y, Cai G, Geng W, Hu Z, Cao J, Zhang W, Cao Z, Chu H, Sun L, Wang P
Cell Discov (2024) 10 pp. 14-14 [ Pubmed: 38320990 DOI: doi:10.1038/s41421-024-00648-1 ]
- Spike glycoprotein (131 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars spike protein (s) in complex with broadly neutralizing antibody pw5-5 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Pw5-5 heavy chain (49 kDa, Protein from Homo sapiens)
- Pw5-5 light chain (23 kDa, Protein from Homo sapiens)