Cryo-EM structure of neutralizing antibody 8G3 in complex with BA.1 RBD
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9js4
Q-score: 0.434
Liao Y, Ma H, Wang Z, Wang S, He Y, Chang Y, Zong H, Tang H, Wang L, Ke Y, Cai H, Li P, Tang J, Chen H, Drelich A, Peng BH, Hsu J, Tat V, Tseng CK, Song J, Yuan Y, Wu M, Liu J, Yue Y, Zhang X, Wang Z, Yang L, Li J, Ni X, Li H, Xiang Y, Bian Y, Zhang B, Yin H, Dimitrov DS, Gilly J, Han L, Jiang H, Xie Y, Zhu J
PNAS (2025) 122 pp. e2406659122-e2406659122 [ Pubmed: 39908098 DOI: doi:10.1073/pnas.2406659122 ]
- Cryo-em structure of neutralizing antibody 8g3 in complex with ba.1 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (137 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Heavy chain of 8g3 (23 kDa, Protein from Homo heidelbergensis)
- Light chain of 8g3 (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
- Tetradecane (198 Da, Ligand)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Tamsulosin (408 Da, Ligand)
Cryo-EM structure of Tdk1-Bdf1 complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9ja5
Q-score: 0.524
Cryo-EM structure of the cortistatin 17-bound Somatostatin receptor 5-Gi protein complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8x8l
Q-score: 0.493
Li J, You C, Li Y, Li C, Fan W, Chen Z, Hu W, Wu K, Xu HE, Zhao LH
PNAS (2024) 121 pp. e2321710121-e2321710121 [ DOI: doi:10.1073/pnas.2321710121 Pubmed: 38885377 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha (41 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cortistatin 17-bound somatostatin receptor 5-gi protein complex (Complex from Homo sapiens)
- Somatostatin receptor type 5 (39 kDa, Protein from Homo sapiens)
- Cortistatin (2 kDa, Protein from Homo sapiens)
Cryo-EM structure of the octreotide-bound Somatostatin receptor 5-Gi protein complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8x8n
Q-score: 0.483
Li J, You C, Li Y, Li C, Fan W, Chen Z, Hu W, Wu K, Xu HE, Zhao LH
PNAS (2024) 121 pp. e2321710121-e2321710121 [ DOI: doi:10.1073/pnas.2321710121 Pubmed: 38885377 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Octreotide-bound somatostatin receptor 5-gi protein complex (Complex from Homo sapiens)
- Octreotide (1 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 5 (39 kDa, Protein from Homo sapiens)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 7.4,200 mM KCl
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8k1j
Q-score: 0.489
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ Pubmed: 38630723 DOI: doi:10.1073/pnas.2320345121 ]
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Chs (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Water (18 Da, Ligand)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 6.0, 5 mM KCl and 135 mM NaCl
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 8k1q
Q-score: 0.41
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ Pubmed: 38630723 DOI: doi:10.1073/pnas.2320345121 ]
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Chs (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Water (18 Da, Ligand)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 7.4, 5 mM KCl and 135 mM NaCl
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 8k1v
Q-score: 0.422
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ Pubmed: 38630723 DOI: doi:10.1073/pnas.2320345121 ]
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Chs (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Water (18 Da, Ligand)
Human TWIK-related acid-sensitive potassium channel TASK3 at pH 6.0, 200 mM KCl
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8k1z
Q-score: 0.42
Lin H, Li J, Zhang Q, Yang H, Chen S
PNAS (2024) 121 pp. e2320345121-e2320345121 [ Pubmed: 38630723 DOI: doi:10.1073/pnas.2320345121 ]
- Potassium channel subfamily k member 9 (31 kDa, Protein from Homo sapiens)
- Potassium ion (39 Da, Ligand)
- Chs (Complex from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Water (18 Da, Ligand)
Voltage-gated sodium channel Nav1.7 variant M9
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8xmm
Q-score: 0.544
Li Z, Wu Q, Huang G, Jin X, Li J, Pan X, Yan N
PNAS (2024) 121 pp. e2322899121-e2322899121 [ Pubmed: 38381792 DOI: doi:10.1073/pnas.2322899121 ]
- 1-o-octadecyl-sn-glycero-3-phosphocholine (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Voltage-gated sodium channel nav1.7-m9 (Complex from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- O-[(r)-{[(2r)-2,3-bis(octadecanoyloxy)propyl]oxy}(hydroxy)phosphoryl]-l-serine (792 Da, Ligand)
- Sodium channel subunit beta-1 (26 kDa, Protein from Homo sapiens)
- Sodium channel protein type 9 subunit alpha (231 kDa, Protein from Homo sapiens)
- (2s,3r,4e)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (421 Da, Ligand)
- Cholesterol (386 Da, Ligand)