The cryo-EM structure of apo KBTBD4
Resolution: 3.83 Å
EM Method: Single-particle
Fitted PDBs: 9dtg
Q-score: 0.432
Yeo MJR, Zhang O, Xie X, Nam E, Payne NC, Gosavi PM, Kwok HS, Iram I, Lee C, Li J, Chen NJ, Nguyen K, Jiang H, Wang ZA, Lee K, Mao H, Harry SA, Barakat IA, Takahashi M, Waterbury AL, Barone M, Mattevi A, Carr SA, Udeshi ND, Bar-Peled L, Cole PA, Mazitschek R, Liau BB, Zheng N
Nature (2025) [ DOI: doi:10.1038/s41586-024-08532-4 Pubmed: 39939761 ]
Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 9ckv
Q-score: 0.482
Wang X, Guillem-Marti J, Kumar S, Lee DS, Cabrerizo-Aguado D, Werther R, Alamo KAE, Zhao YT, Nguyen A, Kopyeva I, Huang B, Li J, Hao Y, Li X, Brizuela-Velasco A, Murray A, Gerben S, Roy A, DeForest CA, Springer T, Ruohola-Baker H, Cooper JA, Campbell MG, Manero JM, Ginebra MP, Baker D
bioRxiv (2024) [ Pubmed: 38979380 DOI: doi:10.1101/2024.06.21.600123 ]
- Protein complex of wild type integrin alpha-5 beta-1 with computationally designed protein neonectin (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Neonectin (11 kDa, Protein from synthetic construct)
- Manganese (ii) ion (54 Da, Ligand)
- Integrin alpha-5 (109 kDa, Protein from Homo sapiens)
- Integrin beta-1 (81 kDa, Protein from Homo sapiens)
Li J, Purser N, Liwocha J, Scott DC, Byers HA, Steigenberger B, Hill S, Tripathi-Giesgen I, Hinkle T, Hansen FM, Prabu JR, Radhakrishnan SK, Kirkpatrick DS, Reichermeier KM, Schulman BA, Kleiger G
Mol Cell (2024) 84 pp. 1304-1320.e16 [ DOI: doi:10.1016/j.molcel.2024.01.022 Pubmed: 38382526 ]
CUL2-RBX1-ELOB/C-FEM1C-SIL1 conformation 1
Liwocha J, Li J, Purser N, Rattanasopa C, Maiwald S, Krist DT, Scott DC, Steigenberger B, Prabu JR, Schulman BA, Kleiger G
Nat Struct Mol Biol (2024) 31 pp. 378-389 [ DOI: doi:10.1038/s41594-023-01206-1 Pubmed: 38326650 ]
- Cul2-rbx1-elob/c-fem1c-sil1 conformation 1 (190 kDa, Complex from Homo sapiens)
CUL2-RBX1-ELOB/C-FEM1C-SIL1 conformation 2
Liwocha J, Li J, Purser N, Rattanasopa C, Maiwald S, Krist DT, Scott DC, Steigenberger B, Prabu JR, Schulman BA, Kleiger G
Nat Struct Mol Biol (2024) 31 pp. 378-389 [ DOI: doi:10.1038/s41594-023-01206-1 Pubmed: 38326650 ]
- Cul2-rbx1-elob/c-fem1c-sil1 conformation 2 (190 kDa, Complex from Homo sapiens)
NEDD8-CUL2-RBX1-ELOB/C-FEM1C-SIL1 conformation 1
Liwocha J, Li J, Purser N, Rattanasopa C, Maiwald S, Krist DT, Scott DC, Steigenberger B, Prabu JR, Schulman BA, Kleiger G
Nat Struct Mol Biol (2024) 31 pp. 378-389 [ DOI: doi:10.1038/s41594-023-01206-1 Pubmed: 38326650 ]
- Nedd8-cul2-rbx1-elob/c-fem1c-sil1 conformation 1 (200 kDa, Complex from Homo sapiens)
NEDD8-CUL2-RBX1-ELOB/C-FEM1C-SIL1 conformation 2
Liwocha J, Li J, Purser N, Rattanasopa C, Maiwald S, Krist DT, Scott DC, Steigenberger B, Prabu JR, Schulman BA, Kleiger G
Nat Struct Mol Biol (2024) 31 pp. 378-389 [ DOI: doi:10.1038/s41594-023-01206-1 Pubmed: 38326650 ]
- Nedd8-cul2-rbx1-elob/c-fem1c-sil1 conformation 2 (200 kDa, Complex from Homo sapiens)
Liwocha J, Li J, Purser N, Rattanasopa C, Maiwald S, Krist DT, Scott DC, Steigenberger B, Prabu JR, Schulman BA, Kleiger G
Nat Struct Mol Biol (2024) 31 pp. 378-389 [ DOI: doi:10.1038/s41594-023-01206-1 Pubmed: 38326650 ]
SRS and Cat modules of human CTLHSR4 bound to multiphosphorylated UBE2H~ubiquitin
Chrustowicz J, Sherpa D, Li J, Langlois CR, Papadopoulou EC, Vu DT, Hehl LA, Karayel O, Beier V, von Gronau S, Muller J, Prabu JR, Mann M, Kleiger G, Alpi AF, Schulman BA
Mol Cell (2024) 84 pp. 293-308.e14 [ DOI: doi:10.1016/j.molcel.2023.11.027 Pubmed: 38113892 ]
Integrin alpha-v beta-8 in complex with minibinder B8_BP_dsulf
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8tcf
Q-score: 0.493
Roy A, Shi L, Chang A, Dong X, Fernandez A, Kraft JC, Li J, Le VQ, Winegar RV, Cherf GM, Slocum D, Poulson PD, Casper GE, Vallecillo-Zuniga ML, Valdoz JC, Miranda MC, Bai H, Kipnis Y, Olshefsky A, Priya T, Carter L, Ravichandran R, Chow CM, Johnson MR, Cheng S, Smith M, Overed-Sayer C, Finch DK, Lowe D, Bera AK, Matute-Bello G, Birkland TP, DiMaio F, Raghu G, Cochran JR, Stewart LJ, Campbell MG, Van Ry PM, Springer T, Baker D
Nat Commun (2023) 14 pp. 5660-5660 [ DOI: doi:10.1038/s41467-023-41272-z Pubmed: 37704610 ]
- Integrin alpha-v heavy chain (48 kDa, Protein from Homo sapiens)
- Minibinder b8_bp_dslf (8 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Ternary complex of integrin heterodimer (alpha-v beta-8) and the de novo minibinder protein b8_bp_dslf (Complex from Homo sapiens)
- Integrin beta-8 (40 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)