Cryo-EM structure of a designed AAV8-based vector
Resolution: 2.08 Å
EM Method: Single-particle
Fitted PDBs: 8jre
Q-score: 0.699
Luo S, Jiang H, Li Q, Qin Y, Yang S, Li J, Xu L, Gou Y, Zhang Y, Liu F, Ke X, Zheng Q, Sun X
Nat Commun (2024) 15 pp. 3780-3780 [ Pubmed: 38710714 DOI: doi:10.1038/s41467-024-48221-4 ]
- Capsid protein (59 kDa, Protein from Adeno-associated virus - 8)
- Adeno-associated virus - 8 (Virus from Adeno-associated virus - 8)
Structure of mouse SCMC bound with KH domain of FILIA
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8h94
Q-score: 0.53
Chi P, Ou G, Qin D, Han Z, Li J, Xiao Q, Gao Z, Xu C, Qi Q, Liu Q, Liu S, Li J, Guo L, Lu Y, Chen J, Wang X, Shi H, Li L, Deng D
Nat Struct Mol Biol (2024) 31 pp. 115-124 [ Pubmed: 38177687 DOI: doi:10.1038/s41594-023-01153-x ]
- Nacht, lrr and pyd domains-containing protein 5 (119 kDa, Protein from Mus musculus)
- Transducin-like enhancer protein 6 (65 kDa, Protein from Mus musculus)
- Oocyte-expressed protein homolog (18 kDa, Protein from Mus musculus)
- Mouse scmc bound with kh domain of filia (Complex from Mus musculus)
Structure of mouse SCMC core complex
Resolution: 2.78 Å
EM Method: Single-particle
Fitted PDBs: 8h96
Q-score: 0.546
Chi P, Ou G, Qin D, Han Z, Li J, Xiao Q, Gao Z, Xu C, Qi Q, Liu Q, Liu S, Li J, Guo L, Lu Y, Chen J, Wang X, Shi H, Li L, Deng D
Nat Struct Mol Biol (2024) 31 pp. 115-124 [ Pubmed: 38177687 DOI: doi:10.1038/s41594-023-01153-x ]
- Nacht, lrr and pyd domains-containing protein 5 (119 kDa, Protein from Mus musculus)
- Transducin-like enhancer protein 6 (65 kDa, Protein from Mus musculus)
- Oocyte-expressed protein homolog (18 kDa, Protein from Mus musculus)
- Mouse scmc core complex (Complex from Mus musculus)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7bvc
Q-score: 0.564
Zhang L, Zhao Y, Gao Y, Wu L, Gao R, Zhang Q, Wang Y, Wu C, Wu F, Gurcha SS, Veerapen N, Batt SM, Zhao W, Qin L, Yang X, Wang M, Zhu Y, Zhang B, Bi L, Zhang X, Yang H, Guddat LW, Xu W, Wang Q, Li J, Besra GS, Rao Z
Science (2020) 368 pp. 1211-1219 [ DOI: doi:10.1126/science.aba9102 Pubmed: 32327601 ]
- Mycobacterium smegmatis arabinosyltransferase emba-embb-acpm2 in complex with ethambutol (Complex)
- Phosphate ion (94 Da, Ligand)
- Ethambutol (204 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Integral membrane indolylacetylinositol arabinosyltransferase embb (119 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Cardiolipin (1 kDa, Ligand)
- [(2z,6e,10e,14z,18e,22z,26z)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl] [(2s,3s,4s,5r)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl] hydrogen phosphate (911 Da, Ligand)
- Acpm (Complex from Mycolicibacterium smegmatis MC2 155)
- 4'-phosphopantetheine (358 Da, Ligand)
- Integral membrane indolylacetylinositol arabinosyltransferase emba (116 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
- Emba-embb (Complex from Mycolicibacterium smegmatis MC2 155)
- Meromycolate extension acyl carrier protein (10 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 7bve
Q-score: 0.552
Zhang L, Zhao Y, Gao Y, Wu L, Gao R, Zhang Q, Wang Y, Wu C, Wu F, Gurcha SS, Veerapen N, Batt SM, Zhao W, Qin L, Yang X, Wang M, Zhu Y, Zhang B, Bi L, Zhang X, Yang H, Guddat LW, Xu W, Wang Q, Li J, Besra GS, Rao Z
Science (2020) 368 pp. 1211-1219 [ DOI: doi:10.1126/science.aba9102 Pubmed: 32327601 ]
- Phosphate ion (94 Da, Ligand)
- Ethambutol (204 Da, Ligand)
- N~3~-[(2s)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-n-(2-sulfanylethyl)-beta-alaninamide (358 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Acpm (Complex from Mycolicibacterium smegmatis MC2 155)
- Integral membrane indolylacetylinositol arabinosyltransferase embc (116 kDa, Protein from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155))
- Mycobacterium smegmatis arabinosyltransferase embc2-acpm2 in complex with ethambutol (Complex)
- Embc (Complex from Mycolicibacterium smegmatis MC2 155)
- Meromycolate extension acyl carrier protein (10 kDa, Protein from Mycolicibacterium smegmatis MC2 155)
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7bvf
Q-score: 0.58
Zhang L, Zhao Y, Gao Y, Wu L, Gao R, Zhang Q, Wang Y, Wu C, Wu F, Gurcha SS, Veerapen N, Batt SM, Zhao W, Qin L, Yang X, Wang M, Zhu Y, Zhang B, Bi L, Zhang X, Yang H, Guddat LW, Xu W, Wang Q, Li J, Besra GS, Rao Z
Science (2020) 368 pp. 1211-1219 [ DOI: doi:10.1126/science.aba9102 Pubmed: 32327601 ]
- Ethambutol (204 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Mycobacterium tuberculosis arabinosyltransferase emba-embb-acpm2 in complex with ethambutol (Complex)
- Probable arabinosyltransferase a (116 kDa, Protein from Mycobacterium tuberculosis H37Rv)
- Mono-trans, octa-cis decaprenyl-phosphate (779 Da, Ligand)
- Acpm (Complex from Mycolicibacterium smegmatis MC2 155)
- Emba and embb (Complex from Mycobacterium tuberculosis H37Rv)
- Probable arabinosyltransferase b (120 kDa, Protein from Mycobacterium tuberculosis H37Rv)
- Cardiolipin (1 kDa, Ligand)
- Meromycolate extension acyl carrier protein (10 kDa, Protein from Mycolicibacterium smegmatis MC2 155)