Merbecovirus MOW15-22 Spike glycoprotein RBD bound to the P. davyi ACE2
Ma CB, Liu C, Park YJ, Tang J, Chen J, Xiong Q, Lee J, Stewart C, Asarnow D, Brown J, Tortorici MA, Yang X, Sun YH, Chen YM, Yu X, Si JY, Liu P, Tong F, Huang ML, Li J, Shi ZL, Deng Z, Veesler D, Yan H
Cell (2025) [ Pubmed: 39922191 DOI: doi:10.1016/j.cell.2024.12.031 ]
- Mow15-22 rbd (34 kDa, Protein from Merbecovirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pteronotus davyi ace2 ectodomain (89 kDa, Protein from Pteronotus davyi)
- Mow15-22 rbd bound to the p. davyi ace2 ectodomain (Complex from Sarbecovirus)
Merbecovirus PnNL2018B Spike glycoprotein RBD bound to the P. Nathusii ACE2
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9dak
Q-score: 0.632
Ma CB, Liu C, Park YJ, Tang J, Chen J, Xiong Q, Lee J, Stewart C, Asarnow D, Brown J, Tortorici MA, Yang X, Sun YH, Chen YM, Yu X, Si JY, Liu P, Tong F, Huang ML, Li J, Shi ZL, Deng Z, Veesler D, Yan H
Cell (2025) [ DOI: doi:10.1016/j.cell.2024.12.031 Pubmed: 39922191 ]
- Ace2 (102 kDa, Protein from Pipistrellus nathusii)
- Water (18 Da, Ligand)
- Merbecovirus pnnl2018b spike glycoprotein rbd bound to the p. nathusii ace2 (Complex from Merbecovirus)
- Spike glycoprotein receptor binding domain (34 kDa, Protein from Merbecovirus)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Tamsulosin (408 Da, Ligand)
- Hexane (86 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 9c44
Q-score: 0.535
Liu P, Huang ML, Guo H, McCallum M, Si JY, Chen YM, Wang CL, Yu X, Shi LL, Xiong Q, Ma CB, Bowen JE, Tong F, Liu C, Sun YH, Yang X, Chen J, Guo M, Li J, Corti D, Veesler D, Shi ZL, Yan H
Nature (2024) 635 pp. 978-986 [ DOI: doi:10.1038/s41586-024-08121-5 Pubmed: 39478224 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S2l20 fab light chain variable region (11 kDa, Protein from Homo sapiens)
- Sars-cov-2 s bound by s2l20 fab (Complex from Homo sapiens)
- S2l20 fab heavy chain variable (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Ebola virus glycoprotein in complex with a broadly neutralizing antibody 2G1
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8y3u
Q-score: 0.455
Fan P, Sun B, Liu Z, Fang T, Ren Y, Zhao X, Song Z, Yang Y, Li J, Yu C, Chen W
Emerg Microbes Infect (2024) 13 pp. 2432366-2432366 [ Pubmed: 39560055 DOI: doi:10.1080/22221751.2024.2432366 ]
- Ebola virus glycoprotein (Complex from Ebola virus)
- Sgp (16 kDa, Protein from Ebola virus)
- Ebola virus glycoprotein in complex with a broadly neutralizing antibody 2g1 (Complex from Henipavirus nipahense)
- 2g1 fab (Complex from Homo sapiens)
- 2g1 vl (11 kDa, Protein from Homo sapiens)
- 2g1 vh (13 kDa, Protein from Homo sapiens)
- Virion spike glycoprotein (10 kDa, Protein from Ebola virus)
The structure of HKU1-B S protein with bsAb1
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8yww
Q-score: 0.291
Sun H, Xia L, Li J, Zhang Y, Zhang G, Huang P, Wang X, Cui Y, Fang T, Fan P, Zhou Q, Chi X, Yu C
Emerg Microbes Infect (2024) 13 pp. 2373307-2373307 [ DOI: doi:10.1080/22221751.2024.2373307 Pubmed: 38953857 ]
- Spike glycoprotein (134 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- The structure of the bsab1-omicron ba.5 s complex (Complex from Severe acute respiratory syndrome coronavirus 2)
- H4b6 light chain (23 kDa, Protein from Homo sapiens)
- The scfv of h4d12 (26 kDa, Protein from Homo sapiens)
- H4b6 heavy chain (23 kDa, Protein from Homo sapiens)
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8k0d
Q-score: 0.461
Fan P, Sun M, Zhang X, Zhang H, Liu Y, Yao Y, Li M, Fang T, Sun B, Chen Z, Chi X, Chen L, Peng C, Chen Z, Zhang G, Ren Y, Liu Z, Li Y, Li J, Li E, Guan W, Li S, Gong R, Zhang K, Yu C, Chiu S
Nat Commun (2024) 15 pp. 4330-4330 [ DOI: doi:10.1038/s41467-024-48601-w Pubmed: 38773072 ]
- Cryo-em structure of conformation 2 of complex of nipah virus attachment g with 1e5 neutralizing antibody (Complex from Nipah virus)
- The light chain of 1e5 (23 kDa, Protein from Macaca mulatta)
- Glycoprotein g (45 kDa, Protein from Nipah virus)
- The heavy chain of 1e5 (26 kDa, Protein from Macaca mulatta)
Cryo-EM structure of human HCN3 channel in apo state
Resolution: 2.72 Å
EM Method: Single-particle
Fitted PDBs: 8inz
Q-score: 0.526
Yu B, Lu Q, Li J, Cheng X, Hu H, Li Y, Che T, Hua Y, Jiang H, Zhang Y, Xian C, Yang T, Fu Y, Chen Y, Nan W, McCormick PJ, Xiong B, Duan J, Zeng B, Li Y, Fu Y, Zhang J
J Biol Chem (2024) 300 pp. 107288-107288 [ Pubmed: 38636662 DOI: doi:10.1016/j.jbc.2024.107288 ]
- 4-[[(2~{s},4~{a}~{r},6~{s},8~{a}~{s})-6-[(4~{s},5~{r})-4-[(2~{s})-butan-2-yl]-5,9-dimethyl-decyl]-4~{a}-methyl-2,3,4,5,6,7,8,8~{a}-octahydro-1~{h}-naphthalen-2-yl]oxy]-4-oxidanylidene-butanoic acid (492 Da, Ligand)
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (86 kDa, Protein from Homo sapiens)
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (Complex from Homo sapiens)
S protein of Delta variant in complex with ZWC6
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7wwm
Q-score: 0.338
Chi X, Guo Y, Zhang G, Sun H, Zhang J, Li M, Chen Z, Han J, Zhang Y, Zhang X, Fan P, Zhang Z, Wang B, Zai X, Han X, Hao M, Fang T, Xu J, Wu S, Chen Y, Fang Y, Dong Y, Sun B, Zhang J, Li J, Zhao G, Yu C, Zhou Q, Chen W
Signal Transduct Target Ther (2022) 7 pp. 139-139 [ Pubmed: 35478188 DOI: doi:10.1038/s41392-022-00987-z ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of zwc6 (13 kDa, Protein from Homo sapiens)
- S protein of delta variant (Complex from Severe acute respiratory syndrome coronavirus 2)
- Zwc6 (Complex from Homo sapiens)
- Heavy chain of zwc6 (11 kDa, Protein from Homo sapiens)
- S protein of delta variant in complex with zwc6 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)