Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Tamsulosin (408 Da, Ligand)
- Hexane (86 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
The structure of HKU1-B S protein with bsAb1
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8yww
Q-score: 0.291
Sun H, Xia L, Li J, Zhang Y, Zhang G, Huang P, Wang X, Cui Y, Fang T, Fan P, Zhou Q, Chi X, Yu C
Emerg Microbes Infect (2024) 13 pp. 2373307-2373307 [ DOI: doi:10.1080/22221751.2024.2373307 Pubmed: 38953857 ]
- Spike glycoprotein (134 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- The structure of the bsab1-omicron ba.5 s complex (Complex from Severe acute respiratory syndrome coronavirus 2)
- H4b6 light chain (23 kDa, Protein from Homo sapiens)
- The scfv of h4d12 (26 kDa, Protein from Homo sapiens)
- H4b6 heavy chain (23 kDa, Protein from Homo sapiens)
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8k0d
Q-score: 0.461
Fan P, Sun M, Zhang X, Zhang H, Liu Y, Yao Y, Li M, Fang T, Sun B, Chen Z, Chi X, Chen L, Peng C, Chen Z, Zhang G, Ren Y, Liu Z, Li Y, Li J, Li E, Guan W, Li S, Gong R, Zhang K, Yu C, Chiu S
Nat Commun (2024) 15 pp. 4330-4330 [ DOI: doi:10.1038/s41467-024-48601-w Pubmed: 38773072 ]
- Cryo-em structure of conformation 2 of complex of nipah virus attachment g with 1e5 neutralizing antibody (Complex from Nipah virus)
- The light chain of 1e5 (23 kDa, Protein from Macaca mulatta)
- Glycoprotein g (45 kDa, Protein from Nipah virus)
- The heavy chain of 1e5 (26 kDa, Protein from Macaca mulatta)
Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8flm
Q-score: 0.573
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y
Nat Chem Biol (2024) 20 pp. 365-372 [ Pubmed: 37828400 DOI: doi:10.1038/s41589-023-01434-y ]
- 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-n-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1h-indole-6-carboxamide (490 Da, Ligand)
- 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid (427 Da, Ligand)
- Cgamp (674 Da, Ligand)
- Stimulator of interferon genes protein (39 kDa, Protein from Homo sapiens)
- Sting tetramer (300 kDa, Complex from Homo sapiens)
Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with Heme and ATP.
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 7f04
Q-score: 0.561
Li J, Zheng W, Gu M, Han L, Luo Y, Yu K, Sun M, Zong Y, Ma X, Liu B, Lowder EP, Mendez DL, Kranz RG, Zhang K, Zhu J
Nat Commun (2022) 13 pp. 6422-6422 [ Pubmed: 36307425 DOI: doi:10.1038/s41467-022-34136-5 ]
- Cytochrome c-type biogenesis protein ccmabcd (130 kDa, Complex from Escherichia coli BL21(DE3))
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Water (18 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Heme exporter protein b (23 kDa, Protein from Escherichia coli BL21(DE3))
- Cytochrome c biogenesis atp-binding export protein ccma (23 kDa, Protein from Escherichia coli BL21(DE3))
- Protoporphyrin ix containing fe (616 Da, Ligand)
- Heme exporter protein d (7 kDa, Protein from Escherichia coli BL21(DE3))
- Heme exporter protein c (27 kDa, Protein from Escherichia coli BL21(DE3))
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 5l35
Q-score: 0.605
Zhao H, Li K, Lynn AY, Aron KE, Yu G, Jiang W, Tang L
PNAS (2017) 114 pp. 3601-3606 [ DOI: doi:10.1073/pnas.1615025114 Pubmed: 28320961 ]
- Bacteriophage sf6 capsid protein gp5 (Protein from Shigella phage Sf6)
- Shigella phage sf6 (19 MDa, Virus from Shigella phage Sf6)