Cryo-EM Structure of the 3HO-HCAR3-Gi complex
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8jef
Q-score: 0.517
Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y
Cell Rep (2024) 43 pp. 114895-114895 [ DOI: doi:10.1016/j.celrep.2024.114895 Pubmed: 39427321 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- (3s)-3-hydroxyoctanoic acid (160 Da, Ligand)
- Cryo-em structure of the apo hcar3-gi complex (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 3 (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8yvd
Q-score: 0.606
Wang P, Li J, Li T, Li K, Ng PC, Wang S, Chriscoli V, Basle A, Marles-Wright J, Zhang YZ, Liu LN
Sci Adv (2024) 10 pp. eadr4227-eadr4227 [ DOI: doi:10.1126/sciadv.adr4227 Pubmed: 39612341 ]
- Carboxysome shell vertex protein csos4a (8 kDa, Protein from Halothiobacillus neapolitanus)
- Cryo-em structure of carboxysomal midi-shell: icosahedral assembly from csos4a/4b/1a/1b/1c/1d and csos2 c-terminal co-expression (t = 16) (Complex from Halothiobacillus neapolitanus)
- Carboxysome assembly protein csos2b (29 kDa, Protein from Halothiobacillus neapolitanus)
- Major carboxysome shell protein csos1a (9 kDa, Protein from Halothiobacillus neapolitanus)
Resolution: 2.3 Å
EM Method: Single-particle
Fitted PDBs: 8yve
Q-score: 0.734
Wang P, Li J, Li T, Li K, Ng PC, Wang S, Chriscoli V, Basle A, Marles-Wright J, Zhang YZ, Liu LN
Sci Adv (2024) 10 pp. eadr4227-eadr4227 [ DOI: doi:10.1126/sciadv.adr4227 Pubmed: 39612341 ]
- Carboxysomal midi-shell:icosahedral assembly from csos4a/4b/1a/1b/1c/1d and csos2 c-terminal co-expression (t = 9) (Complex from Halothiobacillus neapolitanus)
- Carboxysome shell vertex protein csos4a (8 kDa, Protein from Halothiobacillus neapolitanus)
- Carboxysome assembly protein csos2b (29 kDa, Protein from Halothiobacillus neapolitanus)
- Major carboxysome shell protein csos1a (9 kDa, Protein from Halothiobacillus neapolitanus)
Resolution: 2.99 Å
EM Method: Single-particle
Fitted PDBs: 8yvf
Q-score: 0.569
Wang P, Li J, Li T, Li K, Ng PC, Wang S, Chriscoli V, Basle A, Marles-Wright J, Zhang YZ, Liu LN
Sci Adv (2024) 10 pp. eadr4227-eadr4227 [ DOI: doi:10.1126/sciadv.adr4227 Pubmed: 39612341 ]
- Carboxysome assembly protein csos2b (29 kDa, Protein from Halothiobacillus neapolitanus)
- Cryo-em structure of carboxysomal midi-shell: assembly from csos4a/4b/1a/1b/1c/1d and csos2 c-terminal co-expression (t = 9 q=12) (Complex from Halothiobacillus neapolitanus)
- Carboxysome shell vertex protein csos4a (8 kDa, Protein from Halothiobacillus neapolitanus)
- Major carboxysome shell protein csos1a (9 kDa, Protein from Halothiobacillus neapolitanus)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8yvi
Q-score: 0.587
Wang P, Li J, Li T, Li K, Ng PC, Wang S, Chriscoli V, Basle A, Marles-Wright J, Zhang YZ, Liu LN
Sci Adv (2024) 10 pp. eadr4227-eadr4227 [ DOI: doi:10.1126/sciadv.adr4227 Pubmed: 39612341 ]
- Carboxysome assembly protein csos2b (29 kDa, Protein from Halothiobacillus neapolitanus)
- Cryo-em structure of carboxysomal midi-shell: icosahedral assembly from csos4a/4b/1a/1b/1c/1d and csos2 c-terminal co-expression (t = 13) (Complex from Halothiobacillus neapolitanus)
- Carboxysome shell vertex protein csos4a (8 kDa, Protein from Halothiobacillus neapolitanus)
- Major carboxysome shell protein csos1a (9 kDa, Protein from Halothiobacillus neapolitanus)
Cryo-EM Structure of the compuond 5c-HCAR3-Gi complex
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8jei
Q-score: 0.535
Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y
Cell Rep (2024) 43 pp. 114895-114895 [ DOI: doi:10.1016/j.celrep.2024.114895 Pubmed: 39427321 ]
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 3-nitro-4-(propylamino)benzoic acid (224 Da, Ligand)
- Hydroxycarboxylic acid receptor 3 (44 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of the compound 5c-hcar3-gi complex (Complex from Homo sapiens)
SARS-CoV-2 EG.5.1 spike glycoprotein (closed-2 state)
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8wmd
Q-score: 0.484
Tsujino S, Deguchi S, Nomai T, Padilla-Blanco M, Plianchaisuk A, Wang L, Begum MM, Uriu K, Mizuma K, Nao N, Kojima I, Tsubo T, Li J, Matsumura Y, Nagao M, Oda Y, Tsuda M, Anraku Y, Kita S, Yajima H, Sasaki-Tabata K, Guo Z, Hinay Jr AA, Yoshimatsu K, Yamamoto Y, Nagamoto T, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Nasser H, Jonathan M, Putri O, Kim Y, Chen L, Suzuki R, Tamura T, Maenaka K, Irie T, Matsuno K, Tanaka S, Ito J, Ikeda T, Takayama K, Zahradnik J, Hashiguchi T, Fukuhara T, Sato K
Microbiol Immunol (2024) 68 pp. 305-330 [ Pubmed: 38961765 DOI: doi:10.1111/1348-0421.13165 ]
SARS-CoV-2 EG.5.1 spike glycoprotein (closed-1 state)
Resolution: 2.51 Å
EM Method: Single-particle
Fitted PDBs: 8wmf
Q-score: 0.571
Tsujino S, Deguchi S, Nomai T, Padilla-Blanco M, Plianchaisuk A, Wang L, Begum MM, Uriu K, Mizuma K, Nao N, Kojima I, Tsubo T, Li J, Matsumura Y, Nagao M, Oda Y, Tsuda M, Anraku Y, Kita S, Yajima H, Sasaki-Tabata K, Guo Z, Hinay Jr AA, Yoshimatsu K, Yamamoto Y, Nagamoto T, Asakura H, Nagashima M, Sadamasu K, Yoshimura K, Nasser H, Jonathan M, Putri O, Kim Y, Chen L, Suzuki R, Tamura T, Maenaka K, Irie T, Matsuno K, Tanaka S, Ito J, Ikeda T, Takayama K, Zahradnik J, Hashiguchi T, Fukuhara T, Sato K
Microbiol Immunol (2024) 68 pp. 305-330 [ Pubmed: 38961765 DOI: doi:10.1111/1348-0421.13165 ]
Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8flm
Q-score: 0.573
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y
Nat Chem Biol (2024) 20 pp. 365-372 [ Pubmed: 37828400 DOI: doi:10.1038/s41589-023-01434-y ]
- 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-n-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1h-indole-6-carboxamide (490 Da, Ligand)
- 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid (427 Da, Ligand)
- Cgamp (674 Da, Ligand)
- Stimulator of interferon genes protein (39 kDa, Protein from Homo sapiens)
- Sting tetramer (300 kDa, Complex from Homo sapiens)
Integrin alpha-v beta-8 in complex with minibinder B8_BP_dsulf
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8tcf
Q-score: 0.493
Roy A, Shi L, Chang A, Dong X, Fernandez A, Kraft JC, Li J, Le VQ, Winegar RV, Cherf GM, Slocum D, Poulson PD, Casper GE, Vallecillo-Zuniga ML, Valdoz JC, Miranda MC, Bai H, Kipnis Y, Olshefsky A, Priya T, Carter L, Ravichandran R, Chow CM, Johnson MR, Cheng S, Smith M, Overed-Sayer C, Finch DK, Lowe D, Bera AK, Matute-Bello G, Birkland TP, DiMaio F, Raghu G, Cochran JR, Stewart LJ, Campbell MG, Van Ry PM, Springer T, Baker D
Nat Commun (2023) 14 pp. 5660-5660 [ DOI: doi:10.1038/s41467-023-41272-z Pubmed: 37704610 ]
- Integrin beta-8 (40 kDa, Protein from Homo sapiens)
- Ternary complex of integrin heterodimer (alpha-v beta-8) and the de novo minibinder protein b8_bp_dslf (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Integrin alpha-v heavy chain (48 kDa, Protein from Homo sapiens)
- Minibinder b8_bp_dslf (8 kDa, Protein from synthetic construct)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)