CCHFV GP38 bound with ADI-46143 and ADI-46158 Fabs
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Cell Rep (2024) 43 pp. 114502-114502 [ Pubmed: 39002130 DOI: doi:10.1016/j.celrep.2024.114502 ]
- Cchfv gp38 bound with adi-46143 fab and adi-46158 fab (Complex)
- Adi-46158 fab light chain (Protein from Homo sapiens)
- Adi-46143 fab (Complex from Homo sapiens)
- Adi-46143 fab heavy chain (Protein from Homo sapiens)
- Cchfv gp38 (Protein from Crimean-Congo hemorrhagic fever virus)
- Adi-46143 fab light chain (Protein from Homo sapiens)
- Adi-46158 fab heavy chain (Protein from Homo sapiens)
- Cchfv gp38 (Complex from Crimean-Congo hemorrhagic fever virus)
- Adi-46158 fab (Complex from Homo sapiens)
CCHFV GP38 bound with ADI-58062 and ADI-63530 Fabs
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Cell Rep (2024) 43 pp. 114502-114502 [ Pubmed: 39002130 DOI: doi:10.1016/j.celrep.2024.114502 ]
- Cchfv gp38 bound with adi-58062 fab and adi-63530 fab (Complex)
- Adi-63530 fab (Complex from Homo sapiens)
- Adi-63530 fab light chain (Protein from Homo sapiens)
- Adi-63530 fab heavy chain (Protein from Homo sapiens)
- Cchfv gp38 (Protein from Crimean-Congo hemorrhagic fever virus)
- Adi-58062 fab heavy chain (Protein from Homo sapiens)
- Cchfv gp38 (Complex from Crimean-Congo hemorrhagic fever virus)
- Adi-58062 fab light chain (Protein from Homo sapiens)
- Adi-58062 fab (Complex from Homo sapiens)
CCHFV GP38 bound with ADI-58026 and ADI-63547 Fabs
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Cell Rep (2024) 43 pp. 114502-114502 [ Pubmed: 39002130 DOI: doi:10.1016/j.celrep.2024.114502 ]
- Adi-63547 fab (Complex from Homo sapiens)
- Adi-58026 fab heavy chain (Protein from Homo sapiens)
- Adi-58026 fab (Complex from Homo sapiens)
- Adi-63547 fab light chain (Protein from Homo sapiens)
- Cchfv gp38 bound with adi-58026 fab and adi-63547 fab (Complex)
- Adi-63547 fab heavy chain (Protein from Homo sapiens)
- Adi-58026 fab light chain (Protein from Homo sapiens)
- Cchfv gp38 (Protein from Crimean-Congo hemorrhagic fever virus)
- Cchfv gp38 (Complex from Crimean-Congo hemorrhagic fever virus)
CCHFV GP38 bound to ADI-46152 and ADI-58048 Fabs
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8vww
Q-score: 0.412
Shin OS, Monticelli SR, Hjorth CK, Hornet V, Doyle M, Abelson D, Kuehne AI, Wang A, Bakken RR, Mishra AK, Middlecamp M, Champney E, Stuart L, Maurer DP, Li J, Berrigan J, Barajas J, Balinandi S, Lutwama JJ, Lobel L, Zeitlin L, Walker LM, Dye JM, Chandran K, Herbert AS, Pauli NT, McLellan JS
Cell Rep (2024) 43 pp. 114502-114502 [ Pubmed: 39002130 DOI: doi:10.1016/j.celrep.2024.114502 ]
- Adi-46152 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Adi-58048 fab light chain (23 kDa, Protein from Homo sapiens)
- Gp38 (30 kDa, Protein from Crimean-Congo hemorrhagic fever virus strain IbAr10200)
- Adi-46152 fab (Complex from Homo sapiens)
- Adi-58048 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Adi-46152 fab light chain (22 kDa, Protein from Homo sapiens)
- Adi-58048 fab (Complex from Homo sapiens)
- Cchfv gp38 (Complex from Crimean-Congo hemorrhagic fever virus)
- Cchfv gp38 bound with adi-46152 and adi-58048 fabs (Complex)
Cryo-EM structure of alpha5beta1 integrin in complex with NeoNectin
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 9ckv
Q-score: 0.482
Wang X, Guillem-Marti J, Kumar S, Lee DS, Cabrerizo-Aguado D, Werther R, Alamo KAE, Zhao YT, Nguyen A, Kopyeva I, Huang B, Li J, Hao Y, Li X, Brizuela-Velasco A, Murray A, Gerben S, Roy A, DeForest CA, Springer T, Ruohola-Baker H, Cooper JA, Campbell MG, Manero JM, Ginebra MP, Baker D
bioRxiv (2024) [ Pubmed: 38979380 DOI: doi:10.1101/2024.06.21.600123 ]
- Protein complex of wild type integrin alpha-5 beta-1 with computationally designed protein neonectin (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Neonectin (11 kDa, Protein from synthetic construct)
- Manganese (ii) ion (54 Da, Ligand)
- Integrin alpha-5 (109 kDa, Protein from Homo sapiens)
- Integrin beta-1 (81 kDa, Protein from Homo sapiens)
Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8flk
Q-score: 0.438
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y
Nat Chem Biol (2024) 20 pp. 365-372 [ Pubmed: 37828400 DOI: doi:10.1038/s41589-023-01434-y ]
- 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid (427 Da, Ligand)
- Cgamp (674 Da, Ligand)
- Stimulator of interferon genes protein (39 kDa, Protein from Homo sapiens)
- Sting tetramer (300 kDa, Complex from Homo sapiens)
Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8flm
Q-score: 0.573
Li J, Canham SM, Wu H, Henault M, Chen L, Liu G, Chen Y, Yu G, Miller HR, Hornak V, Brittain SM, Michaud GA, Tutter A, Broom W, Digan ME, McWhirter SM, Sivick KE, Pham HT, Chen CH, Tria GS, McKenna JM, Schirle M, Mao X, Nicholson TB, Wang Y, Jenkins JL, Jain RK, Tallarico JA, Patel SJ, Zheng L, Ross NT, Cho CY, Zhang X, Bai XC, Feng Y
Nat Chem Biol (2024) 20 pp. 365-372 [ Pubmed: 37828400 DOI: doi:10.1038/s41589-023-01434-y ]
- 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid (427 Da, Ligand)
- Stimulator of interferon genes protein (39 kDa, Protein from Homo sapiens)
- Sting tetramer (300 kDa, Complex from Homo sapiens)
- Cgamp (674 Da, Ligand)
- 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-n-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1h-indole-6-carboxamide (490 Da, Ligand)
Human Tom70 in complex with SARS CoV2 Orf9b
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 7kdt
Q-score: 0.473
Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Huttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesbolle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss 3rd FR, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech Jr TH, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat KM, Garcia-Sastre A, Rassen JA, Grosse R, Rosenberg OS, Verba KA, Basler CF, Vignuzzi M, Peden AA, Beltrao P, Krogan NJ
Science (2020) 370 [ DOI: doi:10.1126/science.abe9403 Pubmed: 33060197 ]
- Orf9b protein (10 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Mitochondrial import receptor subunit tom70 (56 kDa, Protein from Homo sapiens)
- Orf9b-tom70 complex (Complex from Homo sapiens)