CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8kex
Q-score: 0.416
Yang J, Zhao T, Fan J, Zou H, Lan G, Guo F, Shi Y, Ke H, Yu H, Yue Z, Wang X, Bai Y, Li S, Liu Y, Wang X, Chen Y, Li Y, Lei X
Cell (2024) 187 pp. 7164-7182.e18 [ DOI: doi:10.1016/j.cell.2024.10.001 Pubmed: 39476841 ]
- (4~{r})-4-[(3~{r},5~{r},8~{r},9~{s},10~{s},12~{s},13~{r},14~{s},17~{r})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{h}-cyclopenta[a]phenanthren-17-yl]pentanoic acid (472 Da, Ligand)
- Soluble cytochrome b562,mas-related g-protein coupled receptor member x4,green fluorescent protein (79 kDa, Protein from Aequorea victoria)
- Cryo-em structure of mrgprx4 complex with agonist dca-3p (Complex from Homo sapiens)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8yvu
Q-score: 0.309
Nature (2025) 637 pp. 453-460 [ Pubmed: 39442557 DOI: doi:10.1038/s41586-024-08229-8 ]
- High affinity immunoglobulin epsilon receptor subunit gamma (4 kDa, Protein from Homo sapiens)
- Structure of ige receptor (Complex from Homo sapiens)
- High affinity immunoglobulin epsilon receptor subunit beta (17 kDa, Protein from Homo sapiens)
- High affinity immunoglobulin epsilon receptor subunit alpha (4 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ceb
Q-score: 0.595
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
Resolution: 3.88 Å
EM Method: Single-particle
Fitted PDBs: 7wp8
Q-score: 0.441
Wu Y, Wang S, Zhang Y, Yuan L, Zheng Q, Wei M, Shi Y, Wang Z, Ma J, Wang K, Nie M, Xiao J, Huang Z, Chen P, Guo H, Lan M, Xu J, Hou W, Hong Y, Chen D, Sun H, Xiong H, Zhou M, Liu C, Guo W, Guo H, Gao J, Gan C, Li Z, Zhang H, Wang X, Li S, Cheng T, Zhao Q, Chen Y, Wu T, Zhang T, Zhang J, Cao H, Zhu H, Yuan Q, Guan Y, Xia N
Cell Host Microbe (2022) 30 pp. 1732-1744.e7 [ Pubmed: 36323313 DOI: doi:10.1016/j.chom.2022.10.011 ]
- 85f7 light chain (11 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 85f7 heavy chain (13 kDa, Protein from Mus musculus)
- Neutralizing antibodies (Complex from Severe acute respiratory syndrome coronavirus 2)
- Cryo-em structure of sars-cov-2 recombinant spike protein stfk1628x in complex with three neutralizing antibodies (Complex from Mus musculus)
- Spike protein stfk1628x (Complex)
- 83h7 light chain (11 kDa, Protein from Mus musculus)
- 2b4 light chain (12 kDa, Protein from Mus musculus)
- 83h7 heavy chain (13 kDa, Protein from Mus musculus)
- Spike glycoprotein (20 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2b4 heavy chain (13 kDa, Protein from Mus musculus)
Resolution: 2.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ce7
Q-score: 0.606
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 7wp6
Q-score: 0.438
Wu Y, Wang S, Zhang Y, Yuan L, Zheng Q, Wei M, Shi Y, Wang Z, Ma J, Wang K, Nie M, Xiao J, Huang Z, Chen P, Guo H, Lan M, Xu J, Hou W, Hong Y, Chen D, Sun H, Xiong H, Zhou M, Liu C, Guo W, Guo H, Gao J, Gan C, Li Z, Zhang H, Wang X, Li S, Cheng T, Zhao Q, Chen Y, Wu T, Zhang T, Zhang J, Cao H, Zhu H, Yuan Q, Guan Y, Xia N
Cell Host Microbe (2022) 30 pp. 1732-1744.e7 [ Pubmed: 36323313 DOI: doi:10.1016/j.chom.2022.10.011 ]
- 85f7 light chain (11 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 85f7 heavy chain (13 kDa, Protein from Mus musculus)
- Neutralizing antibodies (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein stfk (Complex)
- 83h7 light chain (11 kDa, Protein from Mus musculus)
- 83h7 heavy chain (13 kDa, Protein from Mus musculus)
- 36h6 light chain (12 kDa, Protein from Mus musculus)
- 36h6 heavy chain (13 kDa, Protein from Mus musculus)
- Cryo-em structure of sars-cov-2 recombinant spike protein stfk in complex with three neutralizing antibodies (Complex from Mus musculus)
Cryo-EM structure of alpha-synuclein singlet filament from Juvenile-onset synucleinopathy
Resolution: 2.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bqv
Q-score: 0.74
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Alpha-synuclein singlet filament extracted from the human brain with jos (Tissue from Homo sapiens)
- Unknown protein (613 Da, Protein from Homo sapiens)
CryoEM structure of the TIR domain from AbTir in complex with 3AD
Resolution: 2.74 Å
EM Method: Helical reconstruction
Fitted PDBs: 7uxu
Q-score: 0.636
Manik MK, Shi Y, Li S, Zaydman MA, Damaraju N, Eastman S, Smith TG, Gu W, Masic V, Mosaiab T, Weagley JS, Hancock SJ, Vasquez E, Hartley-Tassell L, Kargios N, Maruta N, Lim BYJ, Burdett H, Landsberg MJ, Schembri MA, Prokes I, Song L, Grant M, DiAntonio A, Nanson JD, Guo M, Milbrandt J, Ve T, Kobe B
Science (2022) 377 pp. eadc8969-eadc8969 [ Pubmed: 36048923 DOI: doi:10.1126/science.adc8969 ]
- Molecular chaperone tir (15 kDa, Protein from Acinetobacter baumannii)
- Filament of the abtir tir domain in complex with 3ad (Complex from Acinetobacter baumannii)
- [[(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{r},3~{s},4~{r},5~{r})-5-(8-azanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate (686 Da, Ligand)
Structure of Gemin5 C-terminal region (protomer)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7xgr
Q-score: 0.505
Guo Q, Zhao S, Francisco-Velilla R, Zhang J, Embarc-Buh A, Abellan S, Lv M, Tang P, Gong Q, Shen H, Sun L, Yao X, Min J, Shi Y, Martinez-Salas E, Zhang K, Xu C
Nat Commun (2022) 13 pp. 5166-5166 [ DOI: doi:10.1038/s41467-022-32883-z Pubmed: 36056043 ]
- Gem-associated protein 5 (75 kDa, Protein from Homo sapiens)
- Gemin5 (750 MDa, Complex from Homo sapiens)
Local CryoEM structure of the SARS-CoV-2 S6P(B.1.1.529) in complex with BD55-3152 Fab
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7wr8
Q-score: 0.48
Cao Y, Yisimayi A, Jian F, Song W, Xiao T, Wang L, Du S, Wang J, Li Q, Chen X, Yu Y, Wang P, Zhang Z, Liu P, An R, Hao X, Wang Y, Wang J, Feng R, Sun H, Zhao L, Zhang W, Zhao D, Zheng J, Yu L, Li C, Zhang N, Wang R, Niu X, Yang S, Song X, Chai Y, Hu Y, Shi Y, Zheng L, Li Z, Gu Q, Shao F, Huang W, Jin R, Shen Z, Wang Y, Wang X, Xiao J, Xie XS
Nature (2022) 608 pp. 593-602 [ DOI: doi:10.1038/s41586-022-04980-y Pubmed: 35714668 ]
- Bd55-3152h (27 kDa, Protein from Homo sapiens)
- Bd55-3152l (24 kDa, Protein from Homo sapiens)
- Complex of bd55-3152 with s6p (Complex from Homo sapiens)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)