Structure of human pyruvate carboxylase
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 8xl9
Q-score: 0.559
Zhou FY, Zhang YY, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/eLife.98885.2 ]
- Biotin (244 Da, Ligand)
- Pyruvate carboxylase, mitochondrial (129 kDa, Protein from Homo sapiens)
- Homotetramer complex of human pyruvate carboxylase (Complex from Homo sapiens)
Structure of human propionyl-CoA carboxylase at apo-state (PCC-Apo)
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8xl3
Q-score: 0.385
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Heterododecamer complex of human propionyl-coa carboxylase at apo-state (pcc-apo) (Complex from Homo sapiens)
- Biotin (244 Da, Ligand)
- Propionyl-coa carboxylase alpha chain, mitochondrial (80 kDa, Protein from Homo sapiens)
- Propionyl-coa carboxylase beta chain, mitochondrial (58 kDa, Protein from Homo sapiens)
Structure of human propionyl-CoA carboxylase in complex with acetyl-CoA (PCC-ACO)
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8xl4
Q-score: 0.358
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Propionyl-coa carboxylase beta chain, mitochondrial (58 kDa, Protein from Homo sapiens)
- Biotin (244 Da, Ligand)
- Heterododecamer complex of human propionyl-coa carboxylase in complex with acetyl-coa (pcc-aco) (Complex from Homo sapiens)
- Acetyl coenzyme *a (809 Da, Ligand)
- Propionyl-coa carboxylase alpha chain, mitochondrial (80 kDa, Protein from Homo sapiens)
Structure of human propionyl-CoA carboxylase in complex with propionyl-CoA (PCC-PCO)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8xl5
Q-score: 0.422
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Propionyl-coa carboxylase beta chain, mitochondrial (58 kDa, Protein from Homo sapiens)
- Biotin (244 Da, Ligand)
- Heterododecamer complex of human propionyl-coa carboxylase in complex with propionyl-coa (pcc-pco) (Complex from Homo sapiens)
- Propionyl coenzyme a (823 Da, Ligand)
- Propionyl-coa carboxylase alpha chain, mitochondrial (80 kDa, Protein from Homo sapiens)
Structure of human 3-methylcrotonyl-CoA carboxylase at apo-state (MCC-Apo)
Resolution: 2.29 Å
EM Method: Single-particle
Fitted PDBs: 8xl6
Q-score: 0.531
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Biotin (244 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Heterododecamer complex of human 3-methylcrotonyl-coa carboxylase at apo-state (mcc-apo) (Complex from Homo sapiens)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
Structure of human 3-methylcrotonyl-CoA carboxylase in complex with acetyl-CoA (MCC-ACO)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8xl7
Q-score: 0.469
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Biotin (244 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Heterododecamer complex of human 3-methylcrotonyl-coa carboxylase in complex with acetyl-coa (mcc-aco) (Complex from Homo sapiens)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
Structure of human 3-methylcrotonyl-CoA carboxylase in complex with propionyl-CoA (MCC-PCO)
Resolution: 2.36 Å
EM Method: Single-particle
Fitted PDBs: 8xl8
Q-score: 0.475
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Biotin (244 Da, Ligand)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Propionyl coenzyme a (823 Da, Ligand)
- Heterododecamer complex of human 3-methylcrotonyl-coa carboxylase in complex with propionyl-coa (mcc-pco) (Complex from Homo sapiens)
Core region of the citrate-induced human acetyl-CoA carboxylase 1 filament (ACC1-citrate)
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 8xkz
Q-score: 0.435
Citrate-induced filament of human acetyl-coenzyme A carboxylase 1 (ACC1-citrate)
Resolution: 4.14 Å
EM Method: Single-particle
Fitted PDBs: 8xl0
Q-score: 0.162
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
Sci Adv (2024) 10 pp. eado4880-eado4880 [ Pubmed: 39383219 DOI: doi:10.1126/sciadv.ado4880 ]
- Biotin (244 Da, Ligand)
- Acetyl-coa carboxylase 1 (265 kDa, Protein from Homo sapiens)
- Citrate-induced filament of human acetyl-coenzyme a carboxylase 1 (acc1-citrate) (Complex from Homo sapiens)
Core region of the human acetyl-CoA carboxylase 1 filament in complex with acetyl-CoA (ACC1-inact)
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 8xl1
Q-score: 0.382