Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8yvu
Q-score: 0.309
Nature (2025) 637 pp. 453-460 [ Pubmed: 39442557 DOI: doi:10.1038/s41586-024-08229-8 ]
- High affinity immunoglobulin epsilon receptor subunit gamma (4 kDa, Protein from Homo sapiens)
- Structure of ige receptor (Complex from Homo sapiens)
- High affinity immunoglobulin epsilon receptor subunit beta (17 kDa, Protein from Homo sapiens)
- High affinity immunoglobulin epsilon receptor subunit alpha (4 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
The structure of IgE receptor binding to IgE
Resolution: 3.14 Å
EM Method: Single-particle
Fitted PDBs: 8ywa
Q-score: 0.236
Nature (2025) 637 pp. 453-460 [ Pubmed: 39442557 DOI: doi:10.1038/s41586-024-08229-8 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Immunoglobulin heavy constant epsilon (63 kDa, Protein from Homo sapiens)
- High affinity immunoglobulin epsilon receptor subunit alpha (30 kDa, Protein from Homo sapiens)
- Immunoglobulin kappa constant (27 kDa, Protein from Homo sapiens)
- High affinity immunoglobulin epsilon receptor subunit gamma (9 kDa, Protein from Homo sapiens)
- High affinity immunoglobulin epsilon receptor subunit beta (30 kDa, Protein from Homo sapiens)
- The structure of ige receptor binding to ige (Complex from Homo sapiens)
Core region of the citrate-induced human acetyl-CoA carboxylase 1 filament (ACC1-citrate)
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 8xkz
Q-score: 0.435
Citrate-induced filament of human acetyl-coenzyme A carboxylase 1 (ACC1-citrate)
Resolution: 4.14 Å
EM Method: Single-particle
Fitted PDBs: 8xl0
Q-score: 0.162
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
Sci Adv (2024) 10 pp. eado4880-eado4880 [ Pubmed: 39383219 DOI: doi:10.1126/sciadv.ado4880 ]
- Biotin (244 Da, Ligand)
- Acetyl-coa carboxylase 1 (265 kDa, Protein from Homo sapiens)
- Citrate-induced filament of human acetyl-coenzyme a carboxylase 1 (acc1-citrate) (Complex from Homo sapiens)
Core region of the human acetyl-CoA carboxylase 1 filament in complex with acetyl-CoA (ACC1-inact)
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 8xl1
Q-score: 0.382
Human acetyl-CoA carboxylase 1 filament in complex with acetyl-CoA (ACC1-inact)
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8xl2
Q-score: 0.185
Cryo-EM structure of human gamma-secretase in complex with RO4929097
Guo X, Li H, Lu X, Liu H, U K, Yan C, Lei J, Huang J, Zhou R, Shi Y
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01439-8 Pubmed: 39653842 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cryo-em structure of human gamma-secretase in complex with ro4929097 (Complex from Homo sapiens)
- 2,2-dimethyl-n-[(7s)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-n'-(2,2,3,3,3-pentafluoropropyl)propanediamide (469 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nicastrin (77 kDa, Protein from Homo sapiens)
Cryo-EM structure of human gamma-secretase in complex with Crenigacestat
Guo X, Li H, Lu X, Liu H, U K, Yan C, Lei J, Huang J, Zhou R, Shi Y
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01439-8 Pubmed: 39653842 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- 4,4,4-tris(fluoranyl)-n-[(2s)-1-[[(7s)-5-(2-hydroxyethyl)-6-oxidanylidene-7h-pyrido[2,3-d][3]benzazepin-7-yl]amino]-1-oxidanylidene-propan-2-yl]butanamide (464 Da, Ligand)
- Cryo-em structure of human gamma-secretase in complex with crenigacestat (Complex from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nicastrin (77 kDa, Protein from Homo sapiens)
Cryo-EM structure of human gamma-secretase in complex with BMS906024
Guo X, Li H, Lu X, Liu H, U K, Yan C, Lei J, Huang J, Zhou R, Shi Y
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01439-8 Pubmed: 39653842 ]
- Cryo-em structure of human gamma-secretase in complex with bms906024 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Osugacestat (556 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nicastrin (77 kDa, Protein from Homo sapiens)
Cryo-EM structure of human gamma-secretase in complex with Nirogacestat
Guo X, Li H, Lu X, Liu H, U K, Yan C, Lei J, Huang J, Zhou R, Shi Y
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01439-8 Pubmed: 39653842 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Nirogacestat (489 Da, Ligand)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Cryo-em structure of human gamma-secretase in complex with nirogacestat (Complex from Homo sapiens)
- Nicastrin (77 kDa, Protein from Homo sapiens)