Cryo-EM structure of human gamma-secretase in complex with RO4929097
Guo X, Li H, Lu X, Liu H, U K, Yan C, Lei J, Huang J, Zhou R, Shi Y
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01439-8 Pubmed: 39653842 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Cryo-em structure of human gamma-secretase in complex with ro4929097 (Complex from Homo sapiens)
- 2,2-dimethyl-n-[(7s)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-n'-(2,2,3,3,3-pentafluoropropyl)propanediamide (469 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nicastrin (77 kDa, Protein from Homo sapiens)
Cryo-EM structure of human gamma-secretase in complex with Crenigacestat
Guo X, Li H, Lu X, Liu H, U K, Yan C, Lei J, Huang J, Zhou R, Shi Y
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01439-8 Pubmed: 39653842 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- 4,4,4-tris(fluoranyl)-n-[(2s)-1-[[(7s)-5-(2-hydroxyethyl)-6-oxidanylidene-7h-pyrido[2,3-d][3]benzazepin-7-yl]amino]-1-oxidanylidene-propan-2-yl]butanamide (464 Da, Ligand)
- Cryo-em structure of human gamma-secretase in complex with crenigacestat (Complex from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nicastrin (77 kDa, Protein from Homo sapiens)
Cryo-EM structure of human gamma-secretase in complex with BMS906024
Guo X, Li H, Lu X, Liu H, U K, Yan C, Lei J, Huang J, Zhou R, Shi Y
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01439-8 Pubmed: 39653842 ]
- Cryo-em structure of human gamma-secretase in complex with bms906024 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Osugacestat (556 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Nicastrin (77 kDa, Protein from Homo sapiens)
Cryo-EM structure of human gamma-secretase in complex with Nirogacestat
Guo X, Li H, Lu X, Liu H, U K, Yan C, Lei J, Huang J, Zhou R, Shi Y
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01439-8 Pubmed: 39653842 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Nirogacestat (489 Da, Ligand)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Cryo-em structure of human gamma-secretase in complex with nirogacestat (Complex from Homo sapiens)
- Nicastrin (77 kDa, Protein from Homo sapiens)
Cryo-EM structure of human gamma-secretase in complex with MK-0752
Guo X, Li H, Lu X, Liu H, U K, Yan C, Lei J, Huang J, Zhou R, Shi Y
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-024-01439-8 Pubmed: 39653842 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Mk-0752 (442 Da, Ligand)
- Cryo-em structure of human gamma-secretase in complex with mk-0752 (Complex from Homo sapiens)
- Nicastrin (77 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
The cryo-EM structure of the human pre-A complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7vpx
Q-score: 0.155
Zhang X, Zhan X, Bian T, Yang F, Li P, Lu Y, Xing Z, Fan R, Zhang QC, Shi Y
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-023-01188-0 Pubmed: 38196034 ]
- Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 1 (88 kDa, Protein from Homo sapiens)
- Spliceostatin a (form ii) (523 Da, Ligand)
- Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
- U1 small nuclear ribonucleoprotein c (17 kDa, Protein from Homo sapiens)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- Pre-mrna (83 kDa, RNA from unidentified adenovirus)
- Human pre-a (Complex from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Probable atp-dependent rna helicase ddx46 (117 kDa, Protein from Homo sapiens)
- Splicing factor 1 (68 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Dnaj homolog subfamily c member 8 (29 kDa, Protein from Homo sapiens)
- Pre-mrna, 5ss (Complex)
- Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
- U1 small nuclear ribonucleoprotein a (31 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- 5ss (3 kDa, RNA from unidentified adenovirus)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- U1 small nuclear ribonucleoprotein 70 kda (51 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Human pre-a complex (Complex from Homo sapiens)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
- U1 snrna (52 kDa, RNA from Homo sapiens)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)
The cryo-EM map of the human 17S U2 snRNP core region
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7evo
Q-score: 0.367
Zhang X, Zhan X, Bian T, Yang F, Li P, Lu Y, Xing Z, Fan R, Zhang QC, Shi Y
Nat Struct Mol Biol (2024) [ DOI: doi:10.1038/s41594-023-01188-0 Pubmed: 38196034 ]
- Splicing factor 3b subunit 4 (44 kDa, Protein from Homo sapiens)
- Hiv tat-specific factor 1 (85 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein e (10 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 1 (146 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 1 (88 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 3 (58 kDa, Protein from Homo sapiens)
- U2 snrna (60 kDa, RNA from Homo sapiens)
- Small nuclear ribonucleoprotein sm d3 (13 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein g (8 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d2 (13 kDa, Protein from Homo sapiens)
- Splicing factor 3b subunit 5 (10 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein a' (28 kDa, Protein from Homo sapiens)
- U2 small nuclear ribonucleoprotein b'' (25 kDa, Protein from Homo sapiens)
- The human u2 snrnp (Complex from Homo sapiens)
- Splicing factor 3b subunit 2 (100 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein sm d1 (13 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein f (9 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Rna helicase (119 kDa, Protein from Homo sapiens)
- Phd finger-like domain-containing protein 5a (12 kDa, Protein from Homo sapiens)
- Splicing factor 3a subunit 2 (49 kDa, Protein from Homo sapiens)
- [(2~{s},3~{s},4~{e},6~{s},7~{r},10~{r})-3,7-dimethyl-2-[(2~{e},4~{e},6~{r})-6-methyl-6-oxidanyl-7-[(2~{r},3~{r})-3-[(2~{r},3~{s})-3-oxidanylpentan-2-yl]oxiran-2-yl]hepta-2,4-dien-2-yl]-7,10-bis(oxidanyl)-12-oxidanylidene-1-oxacyclododec-4-en-6-yl] 4-cycloheptylpiperazine-1-carboxylate (718 Da, Ligand)
- Splicing factor 3b subunit 3 (135 kDa, Protein from Homo sapiens)
- Small nuclear ribonucleoprotein-associated proteins b and b' (24 kDa, Protein from Homo sapiens)