Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ceb
Q-score: 0.595
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
Alpha-synuclein filament assembled in vitro with mutant (7 residues insertion) protein
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
WT alpha-synuclein filament assembled in vitro
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
Resolution: 2.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ce7
Q-score: 0.606
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
Cryo-EM structure of alpha-synuclein singlet filament from Juvenile-onset synucleinopathy
Resolution: 2.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bqv
Q-score: 0.74
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Alpha-synuclein singlet filament extracted from the human brain with jos (Tissue from Homo sapiens)
- Unknown protein (613 Da, Protein from Homo sapiens)
Cryo-EM structure of alpha-synuclein filaments doublet from Juvenile-onset synucleinopathy
Resolution: 2.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bqw
Q-score: 0.652
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Unknown protein (783 Da, Protein from Homo sapiens)
- Alpha-synuclein doublet filament extracted from the human brain with jos (Tissue from Homo sapiens)
Yang Y, Shi Y, Schweighauser M, Zhang X, Kotecha A, Murzin AG, Garringer HJ, Cullinane PW, Saito Y, Foroud T, Warner TT, Hasegawa K, Vidal R, Murayama S, Revesz T, Ghetti B, Hasegawa M, Lashley T, Scheres SHW, Goedert M
Nature (2022) 610 pp. 791-795 [ Pubmed: 36108674 DOI: 10.1038/s41586-022-05319-3 ]
Image sets:
Resolution: 2.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 8a9l
Q-score: 0.653
Yang Y, Shi Y, Schweighauser M, Zhang X, Kotecha A, Murzin AG, Garringer HJ, Cullinane PW, Saito Y, Foroud T, Warner TT, Hasegawa K, Vidal R, Murayama S, Revesz T, Ghetti B, Hasegawa M, Lashley T, Scheres SHW, Goedert M
Nature (2022) 610 pp. 791-795 [ DOI: doi:10.1038/s41586-022-05319-3 Pubmed: 36108674 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Unknown fragment (783 Da, Protein from Homo sapiens)
- Alpha-synuclein filaments extracted from the human brain with pd, pdd, and dlb (Tissue from Homo sapiens)
- Unknown fragment (627 Da, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Cryo-EM reconstruction of TMEM106B fold I-d filaments from case 18 with multiple system atrophy
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lövestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ DOI: 10.1038/s41586-022-04650-z Pubmed: 35344985 ]
Image sets:
TMEM106B filaments with Fold I from Alzheimer's disease (case 1)
Resolution: 2.64 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qvc
Q-score: 0.617
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ DOI: doi:10.1038/s41586-022-04650-z Pubmed: 35344985 ]
- Tmem106b (Tissue from Homo sapiens)
- Transmembrane protein 106b (31 kDa, Protein from Homo sapiens)