CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8k4s
Q-score: 0.521
Yang J, Zhao T, Fan J, Zou H, Lan G, Guo F, Shi Y, Ke H, Yu H, Yue Z, Wang X, Bai Y, Li S, Liu Y, Wang X, Chen Y, Li Y, Lei X
Cell (2024) 187 pp. 7164-7182.e18 [ DOI: doi:10.1016/j.cell.2024.10.001 Pubmed: 39476841 ]
- (4~{r})-4-[(3~{r},5~{r},8~{r},9~{s},10~{s},12~{s},13~{r},14~{s},17~{r})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{h}-cyclopenta[a]phenanthren-17-yl]pentanoic acid (472 Da, Ligand)
- Soluble cytochrome b562,mas-related g-protein coupled receptor member x4,green fluorescent protein (79 kDa, Protein from Aequorea victoria)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (8 kDa, Protein from Homo sapiens)
- Complex of mrgprx4 with gq and agonist dca-3p (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Gs-mini-gq chimera (28 kDa, Protein from Homo sapiens)
CryoEM structure of Gq coupled MRGPRX4 with agonist DCA-3P, local
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8kex
Q-score: 0.416
Yang J, Zhao T, Fan J, Zou H, Lan G, Guo F, Shi Y, Ke H, Yu H, Yue Z, Wang X, Bai Y, Li S, Liu Y, Wang X, Chen Y, Li Y, Lei X
Cell (2024) 187 pp. 7164-7182.e18 [ DOI: doi:10.1016/j.cell.2024.10.001 Pubmed: 39476841 ]
- (4~{r})-4-[(3~{r},5~{r},8~{r},9~{s},10~{s},12~{s},13~{r},14~{s},17~{r})-10,13-dimethyl-12-oxidanyl-3-phosphonooxy-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1~{h}-cyclopenta[a]phenanthren-17-yl]pentanoic acid (472 Da, Ligand)
- Soluble cytochrome b562,mas-related g-protein coupled receptor member x4,green fluorescent protein (79 kDa, Protein from Aequorea victoria)
- Cryo-em structure of mrgprx4 complex with agonist dca-3p (Complex from Homo sapiens)
Structure of human propionyl-CoA carboxylase at apo-state (PCC-Apo)
Resolution: 3.02 Å
EM Method: Single-particle
Fitted PDBs: 8xl3
Q-score: 0.385
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Heterododecamer complex of human propionyl-coa carboxylase at apo-state (pcc-apo) (Complex from Homo sapiens)
- Biotin (244 Da, Ligand)
- Propionyl-coa carboxylase alpha chain, mitochondrial (80 kDa, Protein from Homo sapiens)
- Propionyl-coa carboxylase beta chain, mitochondrial (58 kDa, Protein from Homo sapiens)
Structure of human propionyl-CoA carboxylase in complex with acetyl-CoA (PCC-ACO)
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8xl4
Q-score: 0.358
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Propionyl-coa carboxylase beta chain, mitochondrial (58 kDa, Protein from Homo sapiens)
- Biotin (244 Da, Ligand)
- Heterododecamer complex of human propionyl-coa carboxylase in complex with acetyl-coa (pcc-aco) (Complex from Homo sapiens)
- Acetyl coenzyme *a (809 Da, Ligand)
- Propionyl-coa carboxylase alpha chain, mitochondrial (80 kDa, Protein from Homo sapiens)
Structure of human propionyl-CoA carboxylase in complex with propionyl-CoA (PCC-PCO)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8xl5
Q-score: 0.422
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Propionyl-coa carboxylase beta chain, mitochondrial (58 kDa, Protein from Homo sapiens)
- Biotin (244 Da, Ligand)
- Heterododecamer complex of human propionyl-coa carboxylase in complex with propionyl-coa (pcc-pco) (Complex from Homo sapiens)
- Propionyl coenzyme a (823 Da, Ligand)
- Propionyl-coa carboxylase alpha chain, mitochondrial (80 kDa, Protein from Homo sapiens)
Structure of human 3-methylcrotonyl-CoA carboxylase at apo-state (MCC-Apo)
Resolution: 2.29 Å
EM Method: Single-particle
Fitted PDBs: 8xl6
Q-score: 0.531
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Biotin (244 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Heterododecamer complex of human 3-methylcrotonyl-coa carboxylase at apo-state (mcc-apo) (Complex from Homo sapiens)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
Structure of human 3-methylcrotonyl-CoA carboxylase in complex with acetyl-CoA (MCC-ACO)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8xl7
Q-score: 0.469
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Biotin (244 Da, Ligand)
- Acetyl coenzyme *a (809 Da, Ligand)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Heterododecamer complex of human 3-methylcrotonyl-coa carboxylase in complex with acetyl-coa (mcc-aco) (Complex from Homo sapiens)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
Structure of human 3-methylcrotonyl-CoA carboxylase in complex with propionyl-CoA (MCC-PCO)
Resolution: 2.36 Å
EM Method: Single-particle
Fitted PDBs: 8xl8
Q-score: 0.475
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
eLife (2024) [ DOI: doi:10.7554/elife.98885.2 ]
- Biotin (244 Da, Ligand)
- Methylcrotonoyl-coa carboxylase beta chain, mitochondrial (61 kDa, Protein from Homo sapiens)
- Methylcrotonoyl-coa carboxylase subunit alpha, mitochondrial (80 kDa, Protein from Homo sapiens)
- Propionyl coenzyme a (823 Da, Ligand)
- Heterododecamer complex of human 3-methylcrotonyl-coa carboxylase in complex with propionyl-coa (mcc-pco) (Complex from Homo sapiens)
Core region of the citrate-induced human acetyl-CoA carboxylase 1 filament (ACC1-citrate)
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 8xkz
Q-score: 0.435
Citrate-induced filament of human acetyl-coenzyme A carboxylase 1 (ACC1-citrate)
Resolution: 4.14 Å
EM Method: Single-particle
Fitted PDBs: 8xl0
Q-score: 0.162
Zhou F, Zhang Y, Zhu Y, Zhou Q, Shi Y, Hu Q
Sci Adv (2024) 10 pp. eado4880-eado4880 [ Pubmed: 39383219 DOI: doi:10.1126/sciadv.ado4880 ]
- Biotin (244 Da, Ligand)
- Acetyl-coa carboxylase 1 (265 kDa, Protein from Homo sapiens)
- Citrate-induced filament of human acetyl-coenzyme a carboxylase 1 (acc1-citrate) (Complex from Homo sapiens)