P301L tau filaments from human brain
Schweighauser M, Shi Y, Murzin AG, Garringer HJ, Vidal R, Murrell JR, Erro ME, Seelaar H, Ferrer I, van Swieten JC, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.08.15.608062 Pubmed: 39185206 ]
P301T type I tau filaments from human brain
Resolution: 2.26 Å
EM Method: Helical reconstruction
Fitted PDBs: 9gg1
Q-score: 0.69
Schweighauser M, Shi Y, Murzin AG, Garringer HJ, Vidal R, Murrell JR, Erro ME, Seelaar H, Ferrer I, van Swieten JC, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.08.15.608062 Pubmed: 39185206 ]
P301T type II tau filaments from human brain
Schweighauser M, Shi Y, Murzin AG, Garringer HJ, Vidal R, Murrell JR, Erro ME, Seelaar H, Ferrer I, van Swieten JC, Ghetti B, Scheres SHW, Goedert M
bioRxiv (2024) [ DOI: doi:10.1101/2024.08.15.608062 Pubmed: 39185206 ]
Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ceb
Q-score: 0.595
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
Alpha-synuclein filament assembled in vitro with mutant (7 residues insertion) protein
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
WT alpha-synuclein filament assembled in vitro
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
Resolution: 2.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ce7
Q-score: 0.606
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
Cryo-EM structure of alpha-synuclein singlet filament from Juvenile-onset synucleinopathy
Resolution: 2.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bqv
Q-score: 0.74
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Alpha-synuclein singlet filament extracted from the human brain with jos (Tissue from Homo sapiens)
- Unknown protein (613 Da, Protein from Homo sapiens)
Cryo-EM structure of alpha-synuclein filaments doublet from Juvenile-onset synucleinopathy
Resolution: 2.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bqw
Q-score: 0.652
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ DOI: doi:10.1007/s00401-023-02550-8 Pubmed: 36847833 ]
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Unknown protein (783 Da, Protein from Homo sapiens)
- Alpha-synuclein doublet filament extracted from the human brain with jos (Tissue from Homo sapiens)
Mitochondrial DNA dependent RNA polymerase homodimer.
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7pzp
Q-score: 0.323
Zhu X, Xie X, Das H, Tan BG, Shi Y, Al-Behadili A, Peter B, Motori E, Valenzuela S, Posse V, Gustafsson CM, Hallberg BM, Falkenberg M
Cell (2022) 185 pp. 2309- [ Pubmed: 35662414 DOI: doi:10.1016/j.cell.2022.05.006 ]
- Mitochondrial dna-directed rna polymerase dimer. (Complex from Homo sapiens)
- Dna-directed rna polymerase, mitochondrial (137 kDa, Protein from Homo sapiens)
- Polrmt (137 kDa, Complex)