Resolution: 2.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ceb
Q-score: 0.595
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
Alpha-synuclein filament assembled in vitro with mutant (7 residues insertion) protein
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
WT alpha-synuclein filament assembled in vitro
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
Resolution: 2.7 Å
EM Method: Helical reconstruction
Fitted PDBs: 8ce7
Q-score: 0.606
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
Cryo-EM structure of alpha-synuclein singlet filament from Juvenile-onset synucleinopathy
Resolution: 2.0 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bqv
Q-score: 0.74
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
- Water (18 Da, Ligand)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha-synuclein singlet filament extracted from the human brain with jos (Tissue from Homo sapiens)
- Unknown protein (613 Da, Protein from Homo sapiens)
Cryo-EM structure of alpha-synuclein filaments doublet from Juvenile-onset synucleinopathy
Resolution: 2.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 8bqw
Q-score: 0.652
Yang Y, Garringer HJ, Shi Y, Lovestam S, Peak-Chew S, Zhang X, Kotecha A, Bacioglu M, Koto A, Takao M, Spillantini MG, Ghetti B, Vidal R, Murzin AG, Scheres SHW, Goedert M
Acta Neuropathol (2023) 145 pp. 561-572 [ Pubmed: 36847833 DOI: doi:10.1007/s00401-023-02550-8 ]
- Water (18 Da, Ligand)
- Unknown protein (783 Da, Protein from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha-synuclein doublet filament extracted from the human brain with jos (Tissue from Homo sapiens)
Mitochondrial DNA dependent RNA polymerase homodimer.
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7pzp
Q-score: 0.323
Zhu X, Xie X, Das H, Tan BG, Shi Y, Al-Behadili A, Peter B, Motori E, Valenzuela S, Posse V, Gustafsson CM, Hallberg BM, Falkenberg M
Cell (2022) 185 pp. 2309- [ Pubmed: 35662414 DOI: doi:10.1016/j.cell.2022.05.006 ]
- Dna-directed rna polymerase, mitochondrial (137 kDa, Protein from Homo sapiens)
- Polrmt (137 kDa, Complex)
- Mitochondrial dna-directed rna polymerase dimer. (Complex from Homo sapiens)
Resolution: 2.2 Å
EM Method: Helical reconstruction
Fitted PDBs: 8a9l
Q-score: 0.653
Yang Y, Shi Y, Schweighauser M, Zhang X, Kotecha A, Murzin AG, Garringer HJ, Cullinane PW, Saito Y, Foroud T, Warner TT, Hasegawa K, Vidal R, Murayama S, Revesz T, Ghetti B, Hasegawa M, Lashley T, Scheres SHW, Goedert M
Nature (2022) 610 pp. 791-795 [ Pubmed: 36108674 DOI: doi:10.1038/s41586-022-05319-3 ]
- Unknown fragment (627 Da, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Unknown fragment (783 Da, Protein from Homo sapiens)
- Alpha-synuclein (14 kDa, Protein from Homo sapiens)
- Alpha-synuclein filaments extracted from the human brain with pd, pdd, and dlb (Tissue from Homo sapiens)
Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (SAM-TIR:1AD)
Shi Y, Kerry PS, Nanson JD, Bosanac T, Sasaki Y, Krauss R, Saikot FK, Adams SE, Mosaiab T, Masic V, Mao X, Rose F, Vasquez E, Furrer M, Cunnea K, Brearley A, Gu W, Luo Z, Brillault L, Landsberg MJ, DiAntonio A, Kobe B, Milbrandt J, Hughes RO, Ve T
Mol Cell (2022) 82 pp. 1643-1659.e10 [ DOI: doi:10.1016/j.molcel.2022.03.007 Pubmed: 35334231 ]
TMEM106B filaments with Fold I from Alzheimer's disease (case 1)
Resolution: 2.64 Å
EM Method: Helical reconstruction
Fitted PDBs: 7qvc
Q-score: 0.617
Schweighauser M, Arseni D, Bacioglu M, Huang M, Lovestam S, Shi Y, Yang Y, Zhang W, Kotecha A, Garringer HJ, Vidal R, Hallinan GI, Newell KL, Tarutani A, Murayama S, Miyazaki M, Saito Y, Yoshida M, Hasegawa K, Lashley T, Revesz T, Kovacs GG, van Swieten J, Takao M, Hasegawa M, Ghetti B, Spillantini MG, Ryskeldi-Falcon B, Murzin AG, Goedert M, Scheres SHW
Nature (2022) 605 pp. 310-314 [ DOI: doi:10.1038/s41586-022-04650-z Pubmed: 35344985 ]
- Transmembrane protein 106b (31 kDa, Protein from Homo sapiens)
- Tmem106b (Tissue from Homo sapiens)