Modified BG505 SOSIP-based immunogen RC1 in complex with elicited mAb Ab283MUR Fab and 8ANC195 Fab
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
- Elicited ab283mur fab in complex with rc1 sosip and bnab 8anc195 fab (600 kDa, Complex)
- 8anc195 fab (Complex from Homo sapiens)
- Rc1 sosip (Complex from Human immunodeficiency virus 1)
- Ab283mur fab (Complex from Mus musculus)
Modified BG505 SOSIP-based immunogen RC1 in complex with elicited mAb Ab1170NHP Fab and 8ANC195 Fab
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with Rabbit 2249 post-Prime polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with Rabbit 2249 post-Boost 1 polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with Rabbit 2249 post-Boost 2 polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with Rabbit 2249 post-Boost 3 polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with Rabbit 2249 post-Boost 4 polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with NHP 1 post-Prime polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
Modified BG505 SOSIP-based immunogen RC1 in complex with NHP 1 post-Boost 1 polyclonal Fabs
Escolano A, Gristick HB, Gautam R, DeLaitsch AT, Abernathy ME, Yang Z, Wang H, Hoffmann MAG, Nishimura Y, Wang Z, Koranda N, Kakutani LM, Gao H, Gnanapragasam PNP, Raina H, Gazumyan A, Cipolla M, Oliveira TY, Ramos V, Irvine DJ, Silva M, West Jr AP, Keeffe JR, Barnes CO, Seaman MS, Nussenzweig MC, Martin MA, Bjorkman PJ
Sci Transl Med (2021) 13 pp. eabk1533-eabk1533 [ DOI: doi:10.1126/scitranslmed.abk1533 Pubmed: 34818054 ]
COVID-19 RNA-dependent RNA polymerase post-translocated catalytic complex
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 7bzf
Q-score: 0.47
Wang Q, Wu J, Wang H, Gao Y, Liu Q, Mu A, Ji W, Yan L, Zhu Y, Zhu C, Fang X, Yang X, Huang Y, Gao H, Liu F, Ge J, Sun Q, Yang X, Xu W, Liu Z, Yang H, Lou Z, Jiang B, Guddat LW, Gong P, Rao Z
Cell (2020) 182 pp. 417-428.e13 [ DOI: doi:10.1016/j.cell.2020.05.034 Pubmed: 32526208 ]
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase (108 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 7 (9 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 8 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Rna (5'-r(*up*gp*up*up*cp*gp*ap*cp*gp*ap*cp*ap*cp*a)-3') (4 kDa, RNA from Foot-and-mouth disease virus)
- Structure of covid-19 rna-dependent rna polymerase in complex with rna (155 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Rna (31-mer) (10 kDa, RNA from Foot-and-mouth disease virus)