COVID-19 RNA-dependent RNA polymerase post-translocated catalytic complex
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 7bzf
Q-score: 0.47
Wang Q, Wu J, Wang H, Gao Y, Liu Q, Mu A, Ji W, Yan L, Zhu Y, Zhu C, Fang X, Yang X, Huang Y, Gao H, Liu F, Ge J, Sun Q, Yang X, Xu W, Liu Z, Yang H, Lou Z, Jiang B, Guddat LW, Gong P, Rao Z
Cell (2020) 182 pp. 417-428.e13 [ DOI: doi:10.1016/j.cell.2020.05.034 Pubmed: 32526208 ]
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase (108 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 7 (9 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 8 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Rna (5'-r(*up*gp*up*up*cp*gp*ap*cp*gp*ap*cp*ap*cp*a)-3') (4 kDa, RNA from Foot-and-mouth disease virus)
- Structure of covid-19 rna-dependent rna polymerase in complex with rna (155 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Rna (31-mer) (10 kDa, RNA from Foot-and-mouth disease virus)
COVID-19 RNA-dependent RNA polymerase pre-translocated catalytic complex
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 7c2k
Q-score: 0.581
Wang Q, Wu J, Wang H, Gao Y, Liu Q, Mu A, Ji W, Yan L, Zhu Y, Zhu C, Fang X, Yang X, Huang Y, Gao H, Liu F, Ge J, Sun Q, Yang X, Xu W, Liu Z, Yang H, Lou Z, Jiang B, Guddat LW, Gong P, Rao Z
Cell (2020) 182 pp. 417-428.e13 [ DOI: doi:10.1016/j.cell.2020.05.034 Pubmed: 32526208 ]
- Zinc ion (65 Da, Ligand)
- Covid-19 rna-dependent rna polymerase pre-translocated catalytic complex (Complex from Severe acute respiratory syndrome coronavirus 2)
- Rna-directed rna polymerase (108 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 7 (9 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Rna (29-mer) (9 kDa, RNA from Foot-and-mouth disease virus)
- Rna (5'-r(*up*gp*up*up*cp*gp*ap*cp*gp*ap*cp*ap*cp*ap*gp*g*(f86)p*g)-3') (5 kDa, RNA from Foot-and-mouth disease virus)
- Non-structural protein 8 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch bNAb 10-1074
Resolution: 4.05 Å
EM Method: Single-particle
Fitted PDBs: 6orn
Q-score: 0.423
Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West Jr AP, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC
Nature (2019) 570 pp. 468-473 [ DOI: doi:10.1038/s41586-019-1250-z Pubmed: 31142836 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rc1 variant of hiv-1 env glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 10-1074 antibody fab light chain (23 kDa, Protein from Homo sapiens)
- 10-1074 fab (Complex from Homo sapiens)
- Rc1 variant of bg505 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Complex of rc1 variant of bg505 sosip.664 trimer with three 10-1074 fabs and three cd4bs fabs (600 kDa, Complex from Human immunodeficiency virus 1)
- 10-1074 antibody fab heavy chain (25 kDa, Protein from Homo sapiens)
- Rc1 variant of hiv-1 env glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6oro
Q-score: 0.465
Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West Jr AP, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC
Nature (2019) 570 pp. 468-473 [ DOI: doi:10.1038/s41586-019-1250-z Pubmed: 31142836 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rc1 variant of hiv-1 env glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Complex of rc1 variant of bg505 sosip.664 trimer with three elicted ab874nhp fabs and three human bnab 8anc195 fabs (150 kDa, Complex from Human immunodeficiency virus 1)
- Ab874nhp antibody fab heavy chain (26 kDa, Protein from Macaca mulatta)
- Rc1 variant of bg505 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Ab874nhp fab (Complex from Macaca mulatta)
- Rc1 variant of hiv-1 env glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Ab874nhp antibody fab light chain (24 kDa, Protein from Macaca mulatta)
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 6orp
Q-score: 0.358
Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West Jr AP, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC
Nature (2019) 570 pp. 468-473 [ DOI: doi:10.1038/s41586-019-1250-z Pubmed: 31142836 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rc1 variant of hiv-1 env glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Ab897nhp antibody fab light chain (24 kDa, Protein from Macaca mulatta)
- Ab897nhp antibody fab heavy chain (26 kDa, Protein from Macaca mulatta)
- Rc1 variant of bg505 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Complex of rc1 variant of bg505 sosip.664 trimer with three ab897nhp fabs and three 8anc195 fabs (600 kDa, Complex from Human immunodeficiency virus 1)
- Rc1 variant of hiv-1 env glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- Ab897nhp fab (Complex from Macaca mulatta)
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 6orq
Q-score: 0.381
Escolano A, Gristick HB, Abernathy ME, Merkenschlager J, Gautam R, Oliveira TY, Pai J, West Jr AP, Barnes CO, Cohen AA, Wang H, Golijanin J, Yost D, Keeffe JR, Wang Z, Zhao P, Yao KH, Bauer J, Nogueira L, Gao H, Voll AV, Montefiori DC, Seaman MS, Gazumyan A, Silva M, McGuire AT, Stamatatos L, Irvine DJ, Wells L, Martin MA, Bjorkman PJ, Nussenzweig MC
Nature (2019) 570 pp. 468-473 [ DOI: doi:10.1038/s41586-019-1250-z Pubmed: 31142836 ]
- Ab275mur fab (Complex from Mus musculoides)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rc1 variant of hiv-1 env glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Ab275mur antibody fab light chain (23 kDa, Protein from Mus musculus)
- Ab275mur antibody fab heavy chain (13 kDa, Protein from Mus musculus)
- Rc1 variant of bg505 sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Rc1 variant of hiv-1 env glycoprotein gp41 (16 kDa, Protein from Human immunodeficiency virus 1)
- Complex of rc1 variant of bg505 sosip.664 trimer with three ab275mur fabs and three 8anc195 fabs (600 kDa, Complex from Human immunodeficiency virus 1)
negative stain EM of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195
Resolution: 16.8 Å
EM Method: Single-particle
Fitted PDBs: 5a7x
Q-score: 0.065
Scharf L, Wang H, Gao H, Chen S, McDowall A, Bjorkman P
Cell (2015) 162 pp. 1379-1390 [ DOI: doi:10.1016/J.CELL.2015.08.035 Pubmed: 26359989 ]
- Soluble hiv-1 env trimer bg505 sosip.664 (420 kDa, Protein from Human immunodeficiency virus 1)
- Soluble cd4 (d1-d2 domains) (20 kDa, Protein from Homo sapiens)
- Fab of broadly neutralizing antibody 17b (50 kDa, Protein from Homo sapiens)
- Fab of broadly neutralizing antibody 8anc195 variant g52k5 (50 kDa, Protein from Homo sapiens)
- Soluble hiv-1 env trimer bg505 sosip.664 in complex with soluble cd4s (d1-d2), broadly neutralizing antibody 17b fabs, and broadly neutralizing antibody 8anc195 variant g32k5 fabs (500 kDa, Sample)
cryo-ET subtomogram averaging of BG505 SOSIP.664 in complex with sCD4, 17b, and 8ANC195
Resolution: 23.0 Å
EM Method: Subtomogram averaging
Fitted PDBs: 5a8h
Q-score: 0.06
Scharf L, Wang H, Gao H, Chen S, McDowall A, Bjorkman P
Cell (2015) 162 pp. 1379-1390 [ DOI: doi:10.1016/j.cell.2015.08.035 Pubmed: 26359989 ]
- Soluble hiv-1 env trimer bg505 sosip.664 (420 kDa, Protein from Human immunodeficiency virus 1)
- Soluble cd4 (d1-d2 domains) (20 kDa, Protein from Homo sapiens)
- Fab of broadly neutralizing antibody 17b (50 kDa, Protein from Homo sapiens)
- Fab of broadly neutralizing antibody 8anc195 variant g52k5 (50 kDa, Protein from Homo sapiens)
- Soluble hiv-1 env trimer bg505 sosip.664 in complex with soluble cd4s (d1-d2), broadly neutralizing antibody 17b fabs, and broadly neutralizing antibody 8anc195 variant g32k5 fabs (500 kDa, Sample)