Local refined cryo-EM reconstruction of Omicron BA.5 RBD in complex with 8-9D Fab
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8j1t
Q-score: 0.455
Tai W, Yang K, Liu Y, Li R, Feng S, Chai B, Zhuang X, Qi S, Shi H, Liu Z, Lei J, Ma E, Wang W, Tian C, Le T, Wang J, Chen Y, Tian M, Xiang Y, Yu G, Cheng G
Nat Commun (2023) 14 pp. 8042-8042 [ DOI: doi:10.1038/s41467-023-43798-8 Pubmed: 38052844 ]
- Severe acute respiratory syndrome coronavirus 2 omicron ba.5 rbd bound 8-9d fab (22 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov2 omicron ba.5 rbd (Complex)
- 8-9d heavy chain (12 kDa, Protein from Homo sapiens)
- 8-9d light chain (11 kDa, Protein from Homo sapiens)
- 8-9d fab (Complex from Homo sapiens)
- Spike protein (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM reconstruction of SARS-CoV2 Omicron BA.5 spike in complex with 8-9D Fabs
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8j1v
Q-score: 0.374
Tai W, Yang K, Liu Y, Li R, Feng S, Chai B, Zhuang X, Qi S, Shi H, Liu Z, Lei J, Ma E, Wang W, Tian C, Le T, Wang J, Chen Y, Tian M, Xiang Y, Yu G, Cheng G
Nat Commun (2023) 14 pp. 8042-8042 [ DOI: doi:10.1038/s41467-023-43798-8 Pubmed: 38052844 ]
- Sars-cov2 omicron ba.5 spike ectodomain (Complex)
- 8-9d heavy chain (12 kDa, Protein from Homo sapiens)
- Severe acute respiratory syndrome coronavirus 2 omicron ba.5 spike bound 8-9d fab (369 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- 8-9d light chain (11 kDa, Protein from Homo sapiens)
- Spike protein s2' (123 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 8-9d fab variable region (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 7fjn
Q-score: 0.27
Liang Q, Wang Y, Zhang S, Sun J, Sun W, Li J, Liu Y, Li M, Cheng L, Jiang Y, Wang R, Zhang R, Yang Z, Ren Y, Chen P, Gao P, Yan H, Zhang Z, Zhang Q, Shi X, Wang J, Liu W, Wang X, Ying B, Zhao J, Qi H, Zhang L
iScience (2022) 25 pp. 104043-104043 [ Pubmed: 35291264 DOI: doi:10.1016/j.isci.2022.104043 ]
- T6 heavy chain (12 kDa, Protein from Homo sapiens)
- S protein of south african (b.1.351) sars-cov-2 spike in complex with t6 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- T6 fab (Complex)
- S protein of south african (b.1.351) sars-cov-2 (Complex from Homo sapiens)
- T6 light chain (12 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein,envelope glycoprotein (141 kDa, Protein from Human immunodeficiency virus 1)
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 7fjo
Q-score: 0.106
Liang Q, Wang Y, Zhang S, Sun J, Sun W, Li J, Liu Y, Li M, Cheng L, Jiang Y, Wang R, Zhang R, Yang Z, Ren Y, Chen P, Gao P, Yan H, Zhang Z, Zhang Q, Shi X, Wang J, Liu W, Wang X, Ying B, Zhao J, Qi H, Zhang L
iScience (2022) 25 pp. 104043-104043 [ Pubmed: 35291264 DOI: doi:10.1016/j.isci.2022.104043 ]
- T6 fab (Complex from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S protein of south african (b.1.351) sars-cov-2 spike (Complex)
- T6 light chain (24 kDa, Protein from Homo sapiens)
- S protein of south african (b.1.351) sars-cov-2 spike in complex with t6 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- T6 heavy chain (23 kDa, Protein from Homo sapiens)
The structure of human ABCG5-WT/ABCG8-I419E
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7r87
Q-score: 0.506
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X
PNAS (2021) 118 [ Pubmed: 34404721 DOI: doi:10.1073/pnas.2110483118 ]
- Atp-binding cassette sub-family g member 5 (74 kDa, Protein from Homo sapiens)
- Abcg5/abcg8 transporter (Complex from Homo sapiens)
- Abcg1 transporter with fab 2c7 (150 kDa, Complex)
- Atp-binding cassette sub-family g member 8 (80 kDa, Protein from Homo sapiens)
- 2c7 fab heavy chain (26 kDa, Protein from Mus musculus)
- 2c7 fab light chain (25 kDa, Protein from Mus musculus)
- 2c7 fab (Complex from Mus musculus)
The structure of human ABCG5-I529W/ABCG8-WT
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7r88
Q-score: 0.493
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X
PNAS (2021) 118 [ Pubmed: 34404721 DOI: doi:10.1073/pnas.2110483118 ]
- Atp-binding cassette sub-family g member 8 (80 kDa, Protein from Homo sapiens)
- Abcg5-i529w/abcg8 transporter with fab 2c7 bound (150 kDa, Complex)
- 2c7 fab heavy chain (26 kDa, Protein from Mus musculus)
- 2c7 fab light chain (25 kDa, Protein from Mus musculus)
- Atp-binding cassette sub-family g member 5 (74 kDa, Protein from Homo sapiens)
- Abcg5-i529w/abcg8 transporter (Complex from Homo sapiens)
- Fab 2c7 (Complex from Mus musculus)
The structure of human ABCG5/ABCG8 purified from yeast
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7r89
Q-score: 0.595
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X
PNAS (2021) 118 [ Pubmed: 34404721 DOI: doi:10.1073/pnas.2110483118 ]
- Atp-binding cassette sub-family g member 8 (80 kDa, Protein from Homo sapiens)
- Atp-binding cassette sub-family g member 5 (74 kDa, Protein from Homo sapiens)
- 2c7 fab heavy chain (26 kDa, Protein from Mus musculus)
- 2c7 fab light chain (25 kDa, Protein from Mus musculus)
- Abcg1 transporter (Complex from Homo sapiens)
- Ergosterol (396 Da, Ligand)
- Abcg1 transporter with ergosterol and fab 2c7 bound (150 kDa, Complex)
- Fab 2c7 (Complex from Mus musculus)
The structure of human ABCG5/ABCG8 purified from mammalian cells
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7r8a
Q-score: 0.552
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X
PNAS (2021) 118 [ Pubmed: 34404721 DOI: doi:10.1073/pnas.2110483118 ]
- Atp-binding cassette sub-family g member 8 (80 kDa, Protein from Homo sapiens)
- Atp-binding cassette sub-family g member 5 (74 kDa, Protein from Homo sapiens)
- Abcg1 transporter with cholesterol and fab 2c7 bound (150 kDa, Complex)
- 2c7 fab heavy chain (26 kDa, Protein from Mus musculus)
- 2c7 fab light chain (25 kDa, Protein from Mus musculus)
- Abcg1 transporter (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Fab 2c7 (Complex from Mus musculus)
The structure of human ABCG5/ABCG8 supplemented with cholesterol
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7r8b
Q-score: 0.533
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X
PNAS (2021) 118 [ Pubmed: 34404721 DOI: doi:10.1073/pnas.2110483118 ]
- Atp-binding cassette sub-family g member 8 (80 kDa, Protein from Homo sapiens)
- Atp-binding cassette sub-family g member 5 (74 kDa, Protein from Homo sapiens)
- Abcg1 transporter with cholesterol and fab 2c7 bound (150 kDa, Complex)
- 2c7 fab heavy chain (26 kDa, Protein from Mus musculus)
- 2c7 fab light chain (25 kDa, Protein from Mus musculus)
- Abcg1 transporter with cholesterol bound (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Fab 2c7 (Complex from Mus musculus)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7r8c
Q-score: 0.448
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X
PNAS (2021) 118 [ Pubmed: 34404721 DOI: doi:10.1073/pnas.2110483118 ]
- Isoform 4 of atp-binding cassette sub-family g member 1 (74 kDa, Protein from Homo sapiens)
- Abcg1 transporter with cholesterol bound (150 kDa, Complex from Homo sapiens)