Cryo-EM structure of partial dimeric WDR11-FAM91A1 complex
Deng H, Jia G, Li P, Tang Y, Zhao L, Yang Q, Zhao J, Wang J, Tu Y, Yong X, Zhang S, Mo X, Billadeau DD, Su Z, Jia D
Cell (2024) 187 pp. 4272- [ DOI: doi:10.1016/j.cell.2024.06.024 Pubmed: 39013469 ]
- Wd repeat-containing protein 11 (136 kDa, Protein from Homo sapiens)
- Cryo-em structure of partial dimeric wdr11-fam91a1 complex (Complex from Homo sapiens)
- Protein fam91a1 (95 kDa, Protein from Homo sapiens)
Cryo-EM structure of dimeric WDR11-FAM91A1 complex
Deng H, Jia G, Li P, Tang Y, Zhao L, Yang Q, Zhao J, Wang J, Tu Y, Yong X, Zhang S, Mo X, Billadeau DD, Su Z, Jia D
Cell (2024) 187 pp. 4272- [ DOI: doi:10.1016/j.cell.2024.06.024 Pubmed: 39013469 ]
- Wd repeat-containing protein 11 (136 kDa, Protein from Homo sapiens)
- Protein fam91a1 (95 kDa, Protein from Homo sapiens)
- Cryo-em structure of dimeric wdr11-fam91a1 complex (Complex from Homo sapiens)
dmDicer2-LoqsPD-dsRNA Dimer status
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 7w0a
Q-score: 0.51
Su S, Wang J, Deng T, Yuan X, He J, Liu N, Li X, Huang Y, Wang HW, Ma J
Nature (2022) 607 pp. 399-406 [ DOI: doi:10.1038/s41586-022-04911-x Pubmed: 35768513 ]
- Dicer2-loqspd-dsrna complex at its initial binding state (Complex from Drosophila melanogaster)
- Loquacious, isoform d (38 kDa, Protein from Drosophila melanogaster)
- Rna (30-mer) (10 kDa, RNA from Drosophila melanogaster)
- Rna (32-mer) (10 kDa, RNA from Spodoptera frugiperda)
- Dicer-2, isoform a (198 kDa, Protein from Drosophila melanogaster)
Dicer2-LoqsPD complex at apo status
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 7w0b
Q-score: 0.339
Su S, Wang J, Deng T, Yuan X, He J, Liu N, Li X, Huang Y, Wang HW, Ma J
Nature (2022) 607 pp. 399-406 [ DOI: doi:10.1038/s41586-022-04911-x Pubmed: 35768513 ]
- Loquacious, isoform d (38 kDa, Protein from Drosophila melanogaster)
- Dicer-2, isoform a (198 kDa, Protein from Drosophila melanogaster)
- Dicer2-loqspd complex at its apo status (Complex from Drosophila melanogaster)
Dicer2-Loqs-PD-dsRNA complex at early-translocation state
Resolution: 3.93 Å
EM Method: Single-particle
Fitted PDBs: 7w0c
Q-score: 0.339
Su S, Wang J, Deng T, Yuan X, He J, Liu N, Li X, Huang Y, Wang HW, Ma J
Nature (2022) 607 pp. 399-406 [ DOI: doi:10.1038/s41586-022-04911-x Pubmed: 35768513 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Loquacious, isoform d (38 kDa, Protein from Drosophila melanogaster)
- Rna (35-mer) (16 kDa, RNA from Drosophila melanogaster)
- Dicer2-loqspd-dsrna complex at its early-translocation state (Complex from Drosophila melanogaster)
- Dicer-2, isoform a (198 kDa, Protein from Drosophila melanogaster)
Dicer2-LoqsPD-dsRNA complex at mid-translocation state
Resolution: 4.18 Å
EM Method: Single-particle
Fitted PDBs: 7w0d
Q-score: 0.318
Su S, Wang J, Deng T, Yuan X, He J, Liu N, Li X, Huang Y, Wang HW, Ma J
Nature (2022) 607 pp. 399-406 [ DOI: doi:10.1038/s41586-022-04911-x Pubmed: 35768513 ]
- Magnesium ion (24 Da, Ligand)
- Dicer2-loqspd-dsrna complex at its mid-translocation state (Complex from Drosophila melanogaster)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Loquacious, isoform d (38 kDa, Protein from Drosophila melanogaster)
- Dsrna (16 kDa, RNA from Drosophila melanogaster)
- Dicer-2, isoform a (198 kDa, Protein from Drosophila melanogaster)
dmDicer2-LoqsPD-dsRNA Active-dicing status
Resolution: 4.03 Å
EM Method: Single-particle
Fitted PDBs: 7w0e
Q-score: 0.366
Su S, Wang J, Deng T, Yuan X, He J, Liu N, Li X, Huang Y, Wang HW, Ma J
Nature (2022) 607 pp. 399-406 [ DOI: doi:10.1038/s41586-022-04911-x Pubmed: 35768513 ]
- Magnesium ion (24 Da, Ligand)
- Dsrna (16 kDa, RNA from Drosophila melanogaster)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Loquacious, isoform d (38 kDa, Protein from Drosophila melanogaster)
- Dicer2-loqspd-dsrna complex at its active-dicing state (Complex from Drosophila melanogaster)
- Dicer-2, isoform a (198 kDa, Protein from Drosophila melanogaster)