Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 9dyh
Q-score: 0.476
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Bestrophin-2a (57 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Best2 + glutamate open state (286 kDa, Complex from Homo sapiens)
BEST2 + glutamate closed state
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 9dyi
Q-score: 0.555
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Calcium ion (40 Da, Ligand)
- Best2 + glutamate closed state (286 kDa, Complex from Homo sapiens)
- Bestrophin-2a (57 kDa, Protein from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 9dyo
Q-score: 0.624
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Best2 + paba closed state (286 kDa, Complex from Homo sapiens)
- Bestrophin-2a (57 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Resolution: 2.31 Å
EM Method: Single-particle
Fitted PDBs: 9dyj
Q-score: 0.684
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Best2 + gaba open state (286 kDa, Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Bestrophin-2a (57 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
Resolution: 2.27 Å
EM Method: Single-particle
Fitted PDBs: 9dyk
Q-score: 0.676
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Best2 + gaba closed state (286 kDa, Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Bestrophin-2 (46 kDa, Protein from Homo sapiens)
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 9dyl
Q-score: 0.623
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Best1 + paba open state (338 kDa, Complex from Homo sapiens)
- 4-aminobenzoic acid (137 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Bestrophin-1 (67 kDa, Protein from Homo sapiens)
BEST1 + PABA intermediate state
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 9dym
Q-score: 0.61
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Calcium ion (40 Da, Ligand)
- 4-aminobenzoic acid (137 Da, Ligand)
- Bestrophin-1 (67 kDa, Protein from Homo sapiens)
- Best1 + paba intermediate state (338 kDa, Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
Resolution: 2.44 Å
EM Method: Single-particle
Fitted PDBs: 9dyn
Q-score: 0.642
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Calcium ion (40 Da, Ligand)
- 4-aminobenzoic acid (137 Da, Ligand)
- Best2 + paba open state (286 kDa, Complex from Homo sapiens)
- Bestrophin-2a (57 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
- Tetradecane (198 Da, Ligand)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Tamsulosin (408 Da, Ligand)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8yvz
Q-score: 0.305
To Be Published
- Semliki forest virus viron in complex with vldlr-la3 (Cellular component from Semliki Forest virus 4)
- Calcium ion (40 Da, Ligand)
- Spike glycoprotein e1 (47 kDa, Protein from Semliki Forest virus 4)
- Spike glycoprotein e2 (46 kDa, Protein from Semliki Forest virus 4)
- Spike glycoprotein e3 (5 kDa, Protein from Semliki Forest virus 4)
- Very low-density lipoprotein receptor (4 kDa, Protein from Homo sapiens)
- Capsid protein, partial (17 kDa, Protein from Semliki Forest virus 4)