Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Tamsulosin (408 Da, Ligand)
- Hexane (86 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
Resolution: 2.41 Å
EM Method: Single-particle
Fitted PDBs: 9ctq
Q-score: 0.659
Wang J, Owji AP, Kittredge A, Clark Z, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 8051-8051 [ Pubmed: 39277606 DOI: doi:10.1038/s41467-024-52039-5 ]
- Calcium ion (40 Da, Ligand)
- Bestrophin-1 (67 kDa, Protein from Homo sapiens)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gaba-bound homopentameric complex of best1 anion channel in fully open fffff state (337 kDa, Complex from Homo sapiens)
Best1 + GABA intermediate state 1
Resolution: 2.42 Å
EM Method: Single-particle
Fitted PDBs: 9ctr
Q-score: 0.651
Wang J, Owji AP, Kittredge A, Clark Z, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 8051-8051 [ Pubmed: 39277606 DOI: doi:10.1038/s41467-024-52039-5 ]
- Calcium ion (40 Da, Ligand)
- Gaba-bound homopentameric complex of best1 anion channel in intermediate state 1 icccc (337 kDa, Complex from Homo sapiens)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Bestrophin-1 (67 kDa, Protein from Homo sapiens)
Best1 + GABA intermediate state 2
Resolution: 2.45 Å
EM Method: Single-particle
Fitted PDBs: 9cts
Q-score: 0.64
Wang J, Owji AP, Kittredge A, Clark Z, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 8051-8051 [ Pubmed: 39277606 DOI: doi:10.1038/s41467-024-52039-5 ]
- Gaba-bound homopentameric complex of best1 anion channel in intermediate state 2 icicc (337 kDa, Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Bestrophin-1 (67 kDa, Protein from Homo sapiens)
- Gamma-amino-butanoic acid (103 Da, Ligand)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 9ctt
Q-score: 0.631
Wang J, Owji AP, Kittredge A, Clark Z, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 8051-8051 [ Pubmed: 39277606 DOI: doi:10.1038/s41467-024-52039-5 ]
- Calcium ion (40 Da, Ligand)
- Bestrophin-1 (67 kDa, Protein from Homo sapiens)
- Gaba-bound homopentameric complex of best1 anion channel in fully open fffff state (337 kDa, Complex from Homo sapiens)
Cryo-EM structure of Mycobacterium tuberculosis ATP synthase in complex with bedaquiline(BDQ)
Resolution: 2.58 Å
EM Method: Single-particle
Fitted PDBs: 8j0s
Q-score: 0.592
Zhang Y, Lai Y, Zhou S, Ran T, Zhang Y, Zhao Z, Feng Z, Yu L, Xu J, Shi K, Wang J, Pang Y, Li L, Chen H, Guddat LW, Gao Y, Liu F, Rao Z, Gong H
Nature (2024) 631 pp. 409-414 [ Pubmed: 38961288 DOI: doi:10.1038/s41586-024-07605-8 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp synthase subunit alpha (59 kDa, Protein from Mycobacterium tuberculosis)
- Atp synthase epsilon chain (13 kDa, Protein from Mycobacterium tuberculosis)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp synthase subunit c (8 kDa, Protein from Mycobacterium tuberculosis)
- Bedaquiline (555 Da, Ligand)
- Atp synthase subunit beta (53 kDa, Protein from Mycobacterium tuberculosis)
- Mycobacterium tuberculosis atp synthase in complex with bedaquiline(bdq) (Complex from Mycobacterium tuberculosis)
- Multifunctional fusion protein (48 kDa, Protein from Mycobacterium tuberculosis)
- Atp synthase gamma chain (33 kDa, Protein from Mycobacterium tuberculosis)
- Atp synthase subunit a (27 kDa, Protein from Mycobacterium tuberculosis)
- Atp synthase subunit b (18 kDa, Protein from Mycobacterium tuberculosis)
Cryo-EM structure of Mycobacterium tuberculosis ATP synthase in the apo-form
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8j0t
Q-score: 0.543
Zhang Y, Lai Y, Zhou S, Ran T, Zhang Y, Zhao Z, Feng Z, Yu L, Xu J, Shi K, Wang J, Pang Y, Li L, Chen H, Guddat LW, Gao Y, Liu F, Rao Z, Gong H
Nature (2024) 631 pp. 409-414 [ Pubmed: 38961288 DOI: doi:10.1038/s41586-024-07605-8 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp synthase subunit alpha (59 kDa, Protein from Mycobacterium tuberculosis)
- Mycobacterium tuberculosis atp synthase (Complex from Mycobacterium tuberculosis)
- Atp synthase epsilon chain (13 kDa, Protein from Mycobacterium tuberculosis)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp synthase subunit c (8 kDa, Protein from Mycobacterium tuberculosis)
- Atp synthase subunit beta (53 kDa, Protein from Mycobacterium tuberculosis)
- Multifunctional fusion protein (48 kDa, Protein from Mycobacterium tuberculosis)
- Atp synthase gamma chain (33 kDa, Protein from Mycobacterium tuberculosis)
- Atp synthase subunit a (27 kDa, Protein from Mycobacterium tuberculosis)
- Atp synthase subunit b (18 kDa, Protein from Mycobacterium tuberculosis)
Cryo-EM structure of succinate receptor bound to cis-epoxysuccinic acid coupling to Gi
Wang T, Tang W, Zhu X, Lv Z, Chen J, Li Y, Sun X, Lv H, Gu Q, Li F, Wang J
Cell Res (2024) 34 pp. 590-593 [ DOI: doi:10.1038/s41422-024-00968-7 Pubmed: 38744983 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gpcr complex of succinate receptor (Complex from Homo sapiens)
- (2r,3s)-oxirane-2,3-dicarboxylic acid (132 Da, Ligand)
- Soluble cytochrome b562,succinate receptor 1,oplophorus-luciferin 2-monooxygenase catalytic subunit (75 kDa, Protein from Oplophorus gracilirostris)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of succinate receptor bound to succinate acid coupling MiniGsq
Wang T, Tang W, Zhu X, Lv Z, Chen J, Li Y, Sun X, Lv H, Gu Q, Li F, Wang J
Cell Res (2024) 34 pp. 590-593 [ DOI: doi:10.1038/s41422-024-00968-7 Pubmed: 38744983 ]
- Soluble cytochrome b562,succinate receptor 1,oplophorus-luciferin 2-monooxygenase catalytic subunit (74 kDa, Protein from Oplophorus gracilirostris)
- Gpcr complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Succinic acid (118 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of Mycobacterium tuberculosis ATP synthase Fo in complex with bedaquiline(BDQ)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8j57
Q-score: 0.574
Zhang Y, Lai Y, Zhou S, Ran T, Zhang Y, Zhao Z, Feng Z, Yu L, Xu J, Shi K, Wang J, Pang Y, Li L, Chen H, Guddat LW, Gao Y, Liu F, Rao Z, Gong H
Nature (2024) 631 pp. 409-414 [ Pubmed: 38961288 DOI: doi:10.1038/s41586-024-07605-8 ]
- Atp synthase subunit a (27 kDa, Protein from Mycobacterium tuberculosis)
- Atp synthase subunit c (8 kDa, Protein from Mycobacterium tuberculosis)
- Bedaquiline (555 Da, Ligand)
- Mycobacterium tuberculosis atp synthase fo with bedaquiline(bdq) (Complex from Mycobacterium tuberculosis)