Cryo-EM Structure of Human Niacin Receptor HCA2-Gi protein complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7xk2
Q-score: 0.471
Yang Y, Kang HJ, Gao R, Wang J, Han GW, DiBerto JF, Wu L, Tong J, Qu L, Wu Y, Pileski R, Li X, Zhang XC, Zhao S, Kenakin T, Wang Q, Stevens RC, Peng W, Roth BL, Rao Z, Liu ZJ
Nat Commun (2023) 14 pp. 1692-1692 [ Pubmed: 36973264 DOI: doi:10.1038/s41467-023-37177-6 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Niacin receptor hca2-gi complex (Complex from Homo sapiens)
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (38 kDa, Protein from Homo sapiens)
An Agonist and PAM-bound Class A GPCR with Gi protein complex structure
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7v68
Q-score: 0.334
Wang J, Wu M, Chen Z, Wu L, Wang T, Cao D, Wang H, Liu S, Xu Y, Li F, Liu J, Chen N, Zhao S, Cheng J, Wang S, Hua T
Nat Commun (2022) 13 pp. 2855-2855 [ DOI: doi:10.1038/s41467-022-30595-y Pubmed: 35606397 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Homo sapiens)
- 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-n,n,n-trimethylbut-2-yn-1-aminium (197 Da, Ligand)
- 3-amino-5-chloro-n-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide (437 Da, Ligand)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Muscarinic acetylcholine receptor m4r (Complex)
- Gi complex (Complex from Homo sapiens)
- Muscarinic acetylcholine receptor m4 (39 kDa, Protein from Homo sapiens)
- M4r_iperoxo_ly2119620_gi complex (Complex from Homo sapiens)
Cryo-EM structure of a class A GPCR-G protein complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7v69
Q-score: 0.324
Wang J, Wu M, Chen Z, Wu L, Wang T, Cao D, Wang H, Liu S, Xu Y, Li F, Liu J, Chen N, Zhao S, Cheng J, Wang S, Hua T
Nat Commun (2022) 13 pp. 2855-2855 [ DOI: doi:10.1038/s41467-022-30595-y Pubmed: 35606397 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Homo sapiens)
- M4r-iperoxo and gi protein complex (Complex from Homo sapiens)
- M4r-iperoxo (Complex)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Muscarinic acetylcholine receptor m4 (39 kDa, Protein from Homo sapiens)
- Gi protein (Complex from Homo sapiens)
Cry-EM structure of M4-c110-G protein complex
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7v6a
Q-score: 0.37
Wang J, Wu M, Chen Z, Wu L, Wang T, Cao D, Wang H, Liu S, Xu Y, Li F, Liu J, Chen N, Zhao S, Cheng J, Wang S, Hua T
Nat Commun (2022) 13 pp. 2855-2855 [ DOI: doi:10.1038/s41467-022-30595-y Pubmed: 35606397 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Homo sapiens)
- M4r-compound110-gi complex (Complex from Homo sapiens)
- Scfv16 (27 kDa, Protein from Homo sapiens)
- Muscarinic acetylcholine receptor m4r (Complex)
- Gi complex (Complex from Homo sapiens)
- Muscarinic acetylcholine receptor m4 (39 kDa, Protein from Homo sapiens)
- Methyl 4-[4-(3-methyl-2-oxidanylidene-benzimidazol-1-yl)piperidin-1-yl]piperidine-1-carboxylate (372 Da, Ligand)
Pyochelin synthetase, a dimeric nonribosomal peptide synthetase elongation module
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 7emy
Q-score: 0.43
Wang J, Li D, Chen L, Cao W, Kong L, Zhang W, Croll T, Deng Z, Liang J, Wang Z
Nat Commun (2022) 13 pp. 592-592 [ Pubmed: 35105906 DOI: doi:10.1038/s41467-022-28284-x ]
- Magnesium ion (24 Da, Ligand)
- Adenosine monophosphate (347 Da, Ligand)
- Cysteine (121 Da, Ligand)
- Pyochelin synthetase, a dimeric nonribosomal peptide synthetase elongation module (160 MDa, Cellular component from Pseudomonas aeruginosa PAO1)
- 2-hydroxybenzoic acid (138 Da, Ligand)
- 4'-phosphopantetheine (358 Da, Ligand)
- Dihydroaeruginoic acid synthetase (158 kDa, Protein from Pseudomonas aeruginosa PAO1)
Pyochelin synthetase, a dimeric nonribosomal peptide synthetase elongation module-after-condensation
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 7en1
Q-score: 0.386
Wang J, Li D, Chen L, Cao W, Kong L, Zhang W, Croll T, Deng Z, Liang J, Wang Z
Nat Commun (2022) 13 pp. 592-592 [ Pubmed: 35105906 DOI: doi:10.1038/s41467-022-28284-x ]
- Magnesium ion (24 Da, Ligand)
- Adenosine monophosphate (347 Da, Ligand)
- Cysteine (121 Da, Ligand)
- (4s)-2-(2-hydroxyphenyl)-4,5-dihydro-1,3-thiazole-4-carboxylic acid (223 Da, Ligand)
- Pyochelin synthetase, a dimeric nonribosomal peptide synthetase elongation module (160 MDa, Cellular component from Pseudomonas aeruginosa PAO1)
- 2-hydroxybenzoic acid (138 Da, Ligand)
- 4'-phosphopantetheine (358 Da, Ligand)
- Dihydroaeruginoic acid synthetase (158 kDa, Protein from Pseudomonas aeruginosa PAO1)
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 7en2
Q-score: 0.33
Wang J, Li D, Chen L, Cao W, Kong L, Zhang W, Croll T, Deng Z, Liang J, Wang Z
Nat Commun (2022) 13 pp. 592-592 [ Pubmed: 35105906 DOI: doi:10.1038/s41467-022-28284-x ]
- 4'-phosphopantetheine (358 Da, Ligand)
- Dihydroaeruginoic acid synthetase (158 kDa, Protein from Pseudomonas aeruginosa PAO1)
- Adenosine monophosphate (347 Da, Ligand)
- Pyochelin synthetase, a dimeric nonribosomal peptide synthetase elongation module (160 MDa, Cellular component from Pseudomonas aeruginosa PAO1)
Al-bound structure of the AtALMT1 mutant M60A
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7voj
Q-score: 0.504
Wang J, Yu X, Ding ZJ, Zhang X, Luo Y, Xu X, Xie Y, Li X, Yuan T, Zheng SJ, Yang W, Guo J
Cell Res (2022) 32 pp. 89-98 [ Pubmed: 34799726 DOI: doi:10.1038/s41422-021-00587-6 ]
- Acetic acid (60 Da, Ligand)
- Aluminum-activated malate transporter 1 (56 kDa, Protein from Arabidopsis thaliana)
- Al-bound protein sample of the atalmt1 mutant m60a (120 MDa, Complex from Arabidopsis thaliana)
- Aluminum ion (26 Da, Ligand)
