Cryo-EM structure of the INSL5-bound human relaxin family peptidereceptor 4(RXFP4)-Gi complex
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 7yj4
Q-score: 0.429
Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW
Nat Commun (2023) 14 pp. 492-492 [ Pubmed: 36717591 DOI: doi:10.1038/s41467-023-36182-z ]
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- Insulin-like peptide insl5 a chain (2 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Cryo-em structure of the human relaxin family peptide receptor 4 in complex with insl5 and g protein (Complex)
- Insl5 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (Complex from synthetic construct)
- Relaxin-3 receptor 2 (41 kDa, Protein from Homo sapiens)
- G protein (Complex from Homo sapiens)
- Insulin-like peptide insl5 b chain (2 kDa, Protein from Homo sapiens)
- Human relaxin family peptide receptor 4 (Complex from Homo sapiens)
Cryo-EM structure of the compound 4-bound human relaxin family peptide receptor 4 (RXFP4)-Gi complex
Resolution: 3.03 Å
EM Method: Single-particle
Fitted PDBs: 7yk6
Q-score: 0.419
Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW
Nat Commun (2023) 14 pp. 492-492 [ Pubmed: 36717591 DOI: doi:10.1038/s41467-023-36182-z ]
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- 1-[2-(4-chlorophenyl)ethyl]-3-[(7-ethyl-5-oxidanyl-1h-indol-3-yl)methylideneamino]guanidine (383 Da, Ligand)
- Scfv16 (26 kDa, Protein from synthetic construct)
- G protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Scfv16 (Complex from synthetic construct)
- Relaxin-3 receptor 2 (41 kDa, Protein from Homo sapiens)
- Relaxin family peptide receptor 4 (Complex from Homo sapiens)
- Cryo-em structure of the human relaxin family peptide receptor 4 in complex with compound 4 and g protein (Complex)
Cryo-EM structure of the DC591053-bound human relaxin family peptide receptor 4 (RXFP4)-Gi complex
Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 7yk7
Q-score: 0.451
Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW
Nat Commun (2023) 14 pp. 492-492 [ Pubmed: 36717591 DOI: doi:10.1038/s41467-023-36182-z ]
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- G protein (Complex from Bos taurus)
- Scfv16 (Complex from synthetic construct)
- [(1s)-7-ethoxy-6-methoxy-1-[2-(5-methoxy-1h-indol-3-yl)ethyl]-3,4-dihydro-1h-isoquinolin-2-yl]-morpholin-4-yl-methanone (493 Da, Ligand)
- Cryo-em structure of the human relaxin family peptide receptor 4 in complex with dc591053 and g protein (Complex)
- Relaxin-3 receptor 2 (41 kDa, Protein from Homo sapiens)
- Relaxin family peptide receptor 4 (Complex from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7eib
Q-score: 0.481
Yin YL, Ye C, Zhou F, Wang J, Yang D, Yin W, Wang MW, Xu HE, Jiang Y
Nat Struct Mol Biol (2021) 28 pp. 755-761 [ Pubmed: 34518695 DOI: doi:10.1038/s41594-021-00645-y ]
- Cryo-em structure of the type 1 bradykinin receptor in complex with the des-arg10-kallidin and an gq protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Bos taurus)
- Type 1 bradykinin receptor (Complex)
- G subunit q (gi2-mini-gq chimeric) (Complex from Rattus norvegicus)
- B1 bradykinin receptor (69 kDa, Protein from Homo sapiens)
- G subunit q (gi1-gq chimeric) (41 kDa, Protein from Homo sapiens)
- Lys-arg-pro-pro-gly-phe-ser-pro-phe (1 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus norvegicus)
- Lys-arg-pro-pro-gly-phe-ser-pro-phe (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex)
Cryo-EM structure of the type 2 bradykinin receptor in complex with the bradykinin and an Gq protein
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7f2o
Q-score: 0.436
Yin YL, Ye C, Zhou F, Wang J, Yang D, Yin W, Wang MW, Xu HE, Jiang Y
Nat Struct Mol Biol (2021) 28 pp. 755-761 [ Pubmed: 34518695 DOI: doi:10.1038/s41594-021-00645-y ]
- Arg-pro-pro-gly-phe-ser-pro-phe-arg (1 kDa, Protein from Homo sapiens)
- Single fab chain (svfv16) (26 kDa, Protein from synthetic construct)
- G subunit q (gi1-gq chimeric) (41 kDa, Protein from Homo sapiens)
- B2 bradykinin receptor (67 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Arg-pro-pro-gly-phe-ser-pro-phe-arg (Complex from Rattus norvegicus)
- Cryo-em structure of the type 2 bradykinin receptor in complex with the bradykinin and an gq protein (Complex from Homo sapiens)
- Single fab chain (svfv16) (Complex from Bos taurus)
- Type 2 bradykinin receptor (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex)
- G subunit q (gi2-mini-gq chimeric) (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex)