Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
- Tetradecane (198 Da, Ligand)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Tamsulosin (408 Da, Ligand)
Structure of AtHKT1;1 in NaCl at 2.7 Angstroms resolution
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8w9n
Q-score: 0.633
Wang J, Luo Y, Ye F, Ding ZJ, Zheng SJ, Qiao S, Wang Y, Guo J, Yang W, Su N
Mol Plant (2024) 17 pp. 409-422 [ DOI: doi:10.1016/j.molp.2024.01.007 Pubmed: 38335958 ]
- Sodium ion (22 Da, Ligand)
- Structure of athkt1;1 in nacl at 2.7 angstroms resolution (Complex from Arabidopsis thaliana)
- Sodium transporter hkt1 (57 kDa, Protein from Arabidopsis thaliana)
structure of AtHKT1;1 in KCl at 2.8 Angstroms resolution
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8w9o
Q-score: 0.589
Wang J, Luo Y, Ye F, Ding ZJ, Zheng SJ, Qiao S, Wang Y, Guo J, Yang W, Su N
Mol Plant (2024) 17 pp. 409-422 [ DOI: doi:10.1016/j.molp.2024.01.007 Pubmed: 38335958 ]
- Structure of athkt1;1 in kcl at 2.8 angstroms resolution (Complex from Arabidopsis thaliana)
- Potassium ion (39 Da, Ligand)
- Sodium transporter hkt1 (57 kDa, Protein from Arabidopsis thaliana)
Structure of TaHKT2;1 in NaCl at 2.6 Angstroms resolution
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8w9t
Q-score: 0.617
Wang J, Luo Y, Ye F, Ding ZJ, Zheng SJ, Qiao S, Wang Y, Guo J, Yang W, Su N
Mol Plant (2024) 17 pp. 409-422 [ DOI: doi:10.1016/j.molp.2024.01.007 Pubmed: 38335958 ]
- Hkt2 (60 kDa, Protein from Triticum aestivum)
- Structure of tahkt2;1 in nacl at 2.6 angstroms resolution (Complex from Arabidopsis thaliana)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
structure of TaHKT2;1 in KCl at 2.9 Angstroms resolution
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8w9v
Q-score: 0.598
Wang J, Luo Y, Ye F, Ding ZJ, Zheng SJ, Qiao S, Wang Y, Guo J, Yang W, Su N
Mol Plant (2024) 17 pp. 409-422 [ DOI: doi:10.1016/j.molp.2024.01.007 Pubmed: 38335958 ]
- Hkt2 (60 kDa, Protein from Triticum aestivum)
- Structure of tahkt2;1 in kcl at 2.9 angstroms resolution (Complex from Arabidopsis thaliana)
- Potassium ion (39 Da, Ligand)
CryoEM structure of PS1-containing gamma-secretase in complex with MRK-560
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7y5t
Q-score: 0.56
Guo X, Wang Y, Zhou J, Jin C, Wang J, Jia B, Jing D, Yan C, Lei J, Zhou R, Shi Y
Nat Commun (2022) 13 pp. 6299-6299 [ Pubmed: 36272978 DOI: doi:10.1038/s41467-022-33817-5 ]
- Ps1-containing gamma-secretase in complex with mrk-560 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- ~{n}-[4-[2,5-bis(fluoranyl)phenyl]-4-(4-chlorophenyl)sulfonyl-cyclohexyl]-1,1,1-tris(fluoranyl)methanesulfonamide (517 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Presenilin-1 (52 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
CryoEM structure of PS2-containing gamma-secretase treated with MRK-560
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7y5x
Q-score: 0.532
Guo X, Wang Y, Zhou J, Jin C, Wang J, Jia B, Jing D, Yan C, Lei J, Zhou R, Shi Y
Nat Commun (2022) 13 pp. 6299-6299 [ Pubmed: 36272978 DOI: doi:10.1038/s41467-022-33817-5 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- Presenilin-2 (50 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Ps2-containing gamma-secretase complex treated with mrk-560 (Complex from Homo sapiens)
CryoEM structure of human PS2-containing gamma-secretase
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7y5z
Q-score: 0.476
Guo X, Wang Y, Zhou J, Jin C, Wang J, Jia B, Jing D, Yan C, Lei J, Zhou R, Shi Y
Nat Commun (2022) 13 pp. 6299-6299 [ Pubmed: 36272978 DOI: doi:10.1038/s41467-022-33817-5 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- Human ps2-containing gamma-secretase (Complex from Homo sapiens)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Presenilin-2 (50 kDa, Protein from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 7xxb
Q-score: 0.526
Su N, Zhu A, Tao X, Ding ZJ, Chang S, Ye F, Zhang Y, Zhao C, Chen Q, Wang J, Zhou CY, Guo Y, Jiao S, Zhang S, Wen H, Ma L, Ye S, Zheng SJ, Yang F, Wu S, Guo J
Nature (2022) 609 pp. 616-621 [ DOI: doi:10.1038/s41586-022-05142-w Pubmed: 35917926 ]
- Auxin efflux carrier component 3 (73 kDa, Protein from Arabidopsis thaliana)
- Iaa-bound state atpin3(atpin3-iaa) (Complex from Arabidopsis thaliana)
- 1h-indol-3-ylacetic acid (175 Da, Ligand)
Human bile salt exporter ABCB11 in complex with taurocholate
Resolution: 3.66 Å
EM Method: Single-particle
Fitted PDBs: 7e1a
Q-score: 0.412
Wang L, Hou WT, Wang J, Xu D, Guo C, Sun L, Ruan K, Zhou CZ, Chen Y
Cell Res (2022) 32 pp. 501-504 [ DOI: doi:10.1038/s41422-021-00611-9 Pubmed: 35043010 ]
- Bile salt export pump (146 kDa, Protein from Homo sapiens)
- Human abcb11 in complex with taurocholate (150 kDa, Complex from Homo sapiens)
- Taurocholic acid (515 Da, Ligand)