Cryo-EM structure of human VMAT2 in complex with serotonin.
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8x3k
Q-score: 0.553
Wei F, Liu H, Zhang W, Wang J, Zhang Y
Nat Commun (2025) 16 pp. 323-323 [ Pubmed: 39747030 DOI: doi:10.1038/s41467-024-55361-0 ]
- Soluble cytochrome b562,synaptic vesicular amine transporter (69 kDa, Protein from Homo sapiens)
- Vmat2 (Complex from Homo sapiens)
- Serotonin (176 Da, Ligand)
Cryo-EM structure of human VMAT2 in complex with dopamine.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9kqe
Q-score: 0.516
Wei F, Liu H, Zhang W, Wang J, Zhang Y
Nat Commun (2025) 16 pp. 323-323 [ Pubmed: 39747030 DOI: doi:10.1038/s41467-024-55361-0 ]
- Soluble cytochrome b562,synaptic vesicular amine transporter (69 kDa, Protein from Homo sapiens)
- Vmat2 (Complex from Homo sapiens)
- L-dopamine (153 Da, Ligand)
Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
- Tetradecane (198 Da, Ligand)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Tamsulosin (408 Da, Ligand)
Structure of human TRPV1 in complex with antagonist
Fan J, Ke H, Lei J, Wang J, Tominaga M, Lei X
Nat Commun (2024) 15 pp. 6689-6689 [ Pubmed: 39107321 DOI: doi:10.1038/s41467-024-51085-3 ]
- Transient receptor potential cation channel subfamily v member 1,prescission site,green fluorescent protein (125 kDa, Protein from Pseudotevenvirus RB43)
- Cholesterol (386 Da, Ligand)
- 4-(7-hydroxy-2-isopropyl-4-oxoquinazolin-3(4h)-yl)benzonitrile (305 Da, Ligand)
- Trpv1 (360 kDa, Complex from Homo sapiens)
Structure of human TRPV1 in complex with antagonist --protein purified without CHS
Fan J, Ke H, Lei J, Wang J, Tominaga M, Lei X
Nat Commun (2024) 15 pp. 6689-6689 [ Pubmed: 39107321 DOI: doi:10.1038/s41467-024-51085-3 ]
- Transient receptor potential cation channel subfamily v member 1,green fluorescent protein (125 kDa, Protein from synthetic construct)
- 4-(7-hydroxy-2-isopropyl-4-oxoquinazolin-3(4h)-yl)benzonitrile (305 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Trpv1 (360 kDa, Complex from Homo sapiens)
NTP-bound Pol IV transcription elongation complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8xmb
Q-score: 0.43
Fang C, Huang K, Wu X, Zhang H, Gu Z, Wang J, Zhang Y
Sci Adv (2024) 10 pp. eadq3087-eadq3087 [ DOI: doi:10.1126/sciadv.adq3087 Pubmed: 39178250 ]
- Dna-directed rna polymerases ii and iv subunit 5a (24 kDa, Protein from Arabidopsis thaliana)
- Rna (4 kDa, RNA from synthetic construct)
- Dna-directed rna polymerase iv subunit 7 (19 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 11 (13 kDa, Protein from Arabidopsis thaliana)
- Template_dna (9 kDa, DNA from synthetic construct)
- Dna-directed rna polymerases iv and v subunit 2 (132 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 10 (8 kDa, Protein from Arabidopsis thaliana)
- Ntp-bound pol iv transcription elongation complex (650 kDa, Complex from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 3 (35 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 12 (5 kDa, Protein from Arabidopsis thaliana)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Dna-directed rna polymerase iv subunit 1 (168 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 8b (16 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 6a (16 kDa, Protein from Arabidopsis thaliana)
- Rna-dependent rna polymerase 2 (129 kDa, Protein from Arabidopsis thaliana)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerases ii, iv and v subunit 9a (13 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases iv and v subunit 4 (22 kDa, Protein from Arabidopsis thaliana)
- Nontemplate_dna (6 kDa, DNA from synthetic construct)
- Zinc ion (65 Da, Ligand)
Post-translocated Pol IV transcription elongation complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8xmc
Q-score: 0.417
Fang C, Huang K, Wu X, Zhang H, Gu Z, Wang J, Zhang Y
Sci Adv (2024) 10 pp. eadq3087-eadq3087 [ DOI: doi:10.1126/sciadv.adq3087 Pubmed: 39178250 ]
- Dna-directed rna polymerases ii and iv subunit 5a (24 kDa, Protein from Arabidopsis thaliana)
- Post-translocated pol iv transcription elongation complex (650 kDa, Complex from Arabidopsis thaliana)
- Rna (4 kDa, RNA from synthetic construct)
- Template dna (9 kDa, DNA from synthetic construct)
- Non-template dna (6 kDa, DNA from synthetic construct)
- Dna-directed rna polymerase iv subunit 7 (19 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 11 (13 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases iv and v subunit 2 (132 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 10 (8 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 3 (35 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 12 (5 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerase iv subunit 1 (168 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 8b (16 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 6a (16 kDa, Protein from Arabidopsis thaliana)
- Rna-dependent rna polymerase 2 (129 kDa, Protein from Arabidopsis thaliana)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerases ii, iv and v subunit 9a (13 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases iv and v subunit 4 (22 kDa, Protein from Arabidopsis thaliana)
- Zinc ion (65 Da, Ligand)
Pre-translocated Pol IV transcription elongation complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8xmd
Q-score: 0.383
Fang C, Huang K, Wu X, Zhang H, Gu Z, Wang J, Zhang Y
Sci Adv (2024) 10 pp. eadq3087-eadq3087 [ DOI: doi:10.1126/sciadv.adq3087 Pubmed: 39178250 ]
- Dna-directed rna polymerases ii and iv subunit 5a (24 kDa, Protein from Arabidopsis thaliana)
- Template_dna (10 kDa, DNA from synthetic construct)
- Pre-translocated pol iv transcription elongation complex (650 kDa, Complex from Arabidopsis thaliana)
- Dna-directed rna polymerase iv subunit 7 (19 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 11 (13 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases iv and v subunit 2 (132 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 10 (8 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 3 (35 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 12 (5 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerase iv subunit 1 (168 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 8b (16 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 6a (16 kDa, Protein from Arabidopsis thaliana)
- Rna-dependent rna polymerase 2 (129 kDa, Protein from Arabidopsis thaliana)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerases ii, iv and v subunit 9a (13 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases iv and v subunit 4 (22 kDa, Protein from Arabidopsis thaliana)
- Nontemplate_dna (6 kDa, DNA from synthetic construct)
- Zinc ion (65 Da, Ligand)
- Rna (5 kDa, RNA from synthetic construct)
Backtracked Pol IV transcription elongation complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8xme
Q-score: 0.377
Fang C, Huang K, Wu X, Zhang H, Gu Z, Wang J, Zhang Y
Sci Adv (2024) 10 pp. eadq3087-eadq3087 [ DOI: doi:10.1126/sciadv.adq3087 Pubmed: 39178250 ]
- Dna-directed rna polymerases ii and iv subunit 5a (24 kDa, Protein from Arabidopsis thaliana)
- Template_dna (12 kDa, DNA from synthetic construct)
- Backtracked pol iv transcription elongation complex (650 kDa, Complex from Arabidopsis thaliana)
- Dna-directed rna polymerase iv subunit 7 (19 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 11 (13 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases iv and v subunit 2 (132 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 10 (8 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 3 (35 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 12 (5 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerase iv subunit 1 (168 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 8b (16 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 6a (16 kDa, Protein from Arabidopsis thaliana)
- Rna-dependent rna polymerase 2 (129 kDa, Protein from Arabidopsis thaliana)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerases ii, iv and v subunit 9a (13 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases iv and v subunit 4 (22 kDa, Protein from Arabidopsis thaliana)
- Zinc ion (65 Da, Ligand)
- Nontemplate_dna (12 kDa, DNA from synthetic construct)
- Rna (5 kDa, RNA from synthetic construct)
mycobacterial efflux pump, substrate-bound state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8k1n
Q-score: 0.541
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L
PNAS (2024) 121 pp. e2403421121-e2403421121 [ DOI: doi:10.1073/pnas.2403421121 Pubmed: 39226350 ]
- Rifampicin (822 Da, Ligand)
- Ternary complex of an abc transporter rv1217c-1218c (120 kDa, Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Cardiolipin (1 kDa, Ligand)
- Multidrug efflux system permease protein rv1217c (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Multidrug efflux system atp-binding protein rv1218c (33 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))