JN.1 RBD with Q493E in complex with ACE2
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 9iuu
Q-score: 0.509
Feng L, Sun Z, Zhang Y, Jian F, Yang S, Xia K, Yu L, Wang J, Shao F, Wang X, Cao Y
Cell Discov (2024) 10 pp. 123-123 [ Pubmed: 39616168 DOI: doi:10.1038/s41421-024-00752-2 ]
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
- Jn.1 rbd q493e (Complex from Severe acute respiratory syndrome coronavirus 2)
- Ace2 (Complex from Homo sapiens)
- Jn.1 rbd with q493e in complex with ace2 (Complex)
- Chloride ion (35 Da, Ligand)
Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
- Tetradecane (198 Da, Ligand)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Tamsulosin (408 Da, Ligand)
CryoEM structure of human full-length alpha1beta3gamma2L GABA(A)R in complex with GABA and puerarin
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 9eqg
Q-score: 0.627
Lyu Q, Xue W, Liu R, Ma Q, Kasaragod VB, Sun S, Li Q, Chen Y, Yuan M, Yang Y, Zhang B, Nie A, Jia S, Shen C, Gao P, Rong W, Yu C, Bi Y, Zhang C, Nan F, Ning G, Rao Z, Yang X, Wang J, Wang W
Nature (2024) 634 pp. 936-943 [ Pubmed: 39261733 DOI: doi:10.1038/s41586-024-07929-5 ]
- Gamma-aminobutyric acid receptor subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-dilauroyl-sn-glycero-3-phosphate (535 Da, Ligand)
- Water (18 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (56 kDa, Protein from Homo sapiens)
- [(2r)-1-octadecanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phospho ryl]oxy-propan-2-yl] (8z)-icosa-5,8,11,14-tetraenoate (1 kDa, Ligand)
- Hexadecane (226 Da, Ligand)
- Decane (142 Da, Ligand)
- (1r)-2-{[(s)-{[(2s)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (749 Da, Ligand)
- Puerarin (416 Da, Ligand)
- Cryoem structure of human full-length alpha1beta3gamma2l gaba(a)r in complex with gaba and puerarin (250 kDa, Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit alpha-1 (52 kDa, Protein from Homo sapiens)
Spike Trimer of BA.2.86 in complex with one hACE2
Resolution: 3.33 Å
EM Method: Single-particle
Fitted PDBs: 8whs
Q-score: 0.272
Liu P, Yue C, Meng B, Xiao T, Yang S, Liu S, Jian F, Zhu Q, Yu Y, Ren Y, Wang P, Li Y, Wang J, Mao X, Shao F, Wang Y, Gupta RK, Cao Y, Wang X
Natl Sci Rev (2024) 11 pp. nwae206-nwae206 [ DOI: doi:10.1093/nsr/nwae206 Pubmed: 39071099 ]
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Processed angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
- Severe acute respiratory syndrome coronavirus 2 (Virus from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (134 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Chloride ion (35 Da, Ligand)
Spike Trimer of BA.2.86 in complex with two hACE2s
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8whu
Q-score: 0.261
Liu P, Yue C, Meng B, Xiao T, Yang S, Liu S, Jian F, Zhu Q, Yu Y, Ren Y, Wang P, Li Y, Wang J, Mao X, Shao F, Wang Y, Gupta RK, Cao Y, Wang X
Natl Sci Rev (2024) 11 pp. nwae206-nwae206 [ DOI: doi:10.1093/nsr/nwae206 Pubmed: 39071099 ]
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Processed angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
- Severe acute respiratory syndrome coronavirus 2 (Virus from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (134 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Chloride ion (35 Da, Ligand)
BA.2.86 Spike Trimer in complex with heparan sulfate
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 8xur
Q-score: 0.247
Liu P, Yue C, Meng B, Xiao T, Yang S, Liu S, Jian F, Zhu Q, Yu Y, Ren Y, Wang P, Li Y, Wang J, Mao X, Shao F, Wang Y, Gupta RK, Cao Y, Wang X
Natl Sci Rev (2024) 11 pp. nwae206-nwae206 [ DOI: doi:10.1093/nsr/nwae206 Pubmed: 39071099 ]
- 2-o-sulfo-beta-l-altropyranuronic acid (274 Da, Ligand)
- Ba.2.86 spike trimer in complex with heparan sulfate (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (134 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
JN.1 Spike Trimer in complex with heparan sulfate
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8xus
Q-score: 0.372
Liu P, Yue C, Meng B, Xiao T, Yang S, Liu S, Jian F, Zhu Q, Yu Y, Ren Y, Wang P, Li Y, Wang J, Mao X, Shao F, Wang Y, Gupta RK, Cao Y, Wang X
Natl Sci Rev (2024) 11 pp. nwae206-nwae206 [ DOI: doi:10.1093/nsr/nwae206 Pubmed: 39071099 ]
- 2-o-sulfo-beta-l-altropyranuronic acid (274 Da, Ligand)
- Spike glycoprotein (134 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Jn.1 spike trimer in complex with heparan sulfate (Complex from Severe acute respiratory syndrome coronavirus 2)
XBB.1.5 Spike Trimer in complex with heparan sulfate
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8xut
Q-score: 0.398
Liu P, Yue C, Meng B, Xiao T, Yang S, Liu S, Jian F, Zhu Q, Yu Y, Ren Y, Wang P, Li Y, Wang J, Mao X, Shao F, Wang Y, Gupta RK, Cao Y, Wang X
Natl Sci Rev (2024) 11 pp. nwae206-nwae206 [ DOI: doi:10.1093/nsr/nwae206 Pubmed: 39071099 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Xbb.1.5 spike trimer in complex with heparan sulfate (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2-o-sulfo-beta-l-altropyranuronic acid (274 Da, Ligand)
BA.2.86-T356K Spike Trimer in complex with heparan sulfate (Local refinement)
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 8xuu
Q-score: 0.329
Liu P, Yue C, Meng B, Xiao T, Yang S, Liu S, Jian F, Zhu Q, Yu Y, Ren Y, Wang P, Li Y, Wang J, Mao X, Shao F, Wang Y, Gupta RK, Cao Y, Wang X
Natl Sci Rev (2024) 11 pp. nwae206-nwae206 [ DOI: doi:10.1093/nsr/nwae206 Pubmed: 39071099 ]
- Ba.2.86-t356k spike trimer in complex with heparan sulfate (local refinement) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (134 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2-o-sulfo-beta-l-altropyranuronic acid (274 Da, Ligand)
BA.2.86 RBD in complex with hACE2 (local refinement)
Resolution: 3.93 Å
EM Method: Single-particle
Fitted PDBs: 8whz
Q-score: 0.317
Liu P, Yue C, Meng B, Xiao T, Yang S, Liu S, Jian F, Zhu Q, Yu Y, Ren Y, Wang P, Li Y, Wang J, Mao X, Shao F, Wang Y, Gupta RK, Cao Y, Wang X
Natl Sci Rev (2024) 11 pp. nwae206-nwae206 [ DOI: doi:10.1093/nsr/nwae206 Pubmed: 39071099 ]
- Zinc ion (65 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Severe acute respiratory syndrome coronavirus 2 (Virus from Severe acute respiratory syndrome coronavirus 2)
- Processed angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)