Cryo-EM structure of succinate receptor bound to succinate acid coupling MiniGsq
Wang T, Tang W, Zhu X, Lv Z, Chen J, Li Y, Sun X, Lv H, Gu Q, Li F, Wang J
Cell Res (2024) 34 pp. 590-593 [ DOI: doi:10.1038/s41422-024-00968-7 Pubmed: 38744983 ]
- Soluble cytochrome b562,succinate receptor 1,oplophorus-luciferin 2-monooxygenase catalytic subunit (74 kDa, Protein from Oplophorus gracilirostris)
- Gpcr complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Succinic acid (118 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of human SIDT1 protein with C1 symmetry at neutral pH
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8woq
Q-score: 0.501
Liu W, Tang M, Wang J, Wang F, Song G, Zhang X, Wu S, Ru H
Cell Discov (2024) 10 pp. 21-21 [ Pubmed: 38378654 DOI: doi:10.1038/s41421-024-00647-2 ]
- Water (18 Da, Ligand)
- Ternary complex of sidt1 in complex with unknown lipids (Complex from Homo sapiens)
- Octanoic acid (2-hydroxy-1-hydroxymethyl-heptadec-3-enyl)-amide (425 Da, Ligand)
- Sid1 transmembrane family member 1 (99 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Oleic acid (282 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human SIDT1 protein with C2 symmetry at neutral pH
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8wor
Q-score: 0.533
Liu W, Tang M, Wang J, Wang F, Song G, Zhang X, Wu S, Ru H
Cell Discov (2024) 10 pp. 21-21 [ Pubmed: 38378654 DOI: doi:10.1038/s41421-024-00647-2 ]
- Water (18 Da, Ligand)
- Ternary complex of sidt1 in complex with unknown lipids (Complex from Homo sapiens)
- Octanoic acid (2-hydroxy-1-hydroxymethyl-heptadec-3-enyl)-amide (425 Da, Ligand)
- Sid1 transmembrane family member 1 (99 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Oleic acid (282 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human SIDT1 protein with C1 symmetry at low pH
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8wos
Q-score: 0.418
Liu W, Tang M, Wang J, Wang F, Song G, Zhang X, Wu S, Ru H
Cell Discov (2024) 10 pp. 21-21 [ Pubmed: 38378654 DOI: doi:10.1038/s41421-024-00647-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sid1 transmembrane family member 1 (99 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Human sidt1 at low ph (Complex from Homo sapiens)
Cryo-EM structure of human SIDT1 protein with C2 symmetry at low pH
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8wot
Q-score: 0.458
Liu W, Tang M, Wang J, Wang F, Song G, Zhang X, Wu S, Ru H
Cell Discov (2024) 10 pp. 21-21 [ Pubmed: 38378654 DOI: doi:10.1038/s41421-024-00647-2 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sid1 transmembrane family member 1 (99 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Human sidt1 at low ph (Complex from Homo sapiens)
Cryo-EM structure of FFAR3 bound with valeric acid and AR420626
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8j20
Q-score: 0.393
Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X, Wang J
Cell Res (2024) 34 pp. 323-326 [ Pubmed: 38191689 DOI: doi:10.1038/s41422-023-00914-z ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- The ffar3 complex bound with valeric acid (Complex from Homo sapiens)
- Free fatty acid receptor 3 (35 kDa, Protein from Homo sapiens)
- (4r)-n-[2,5-bis(chloranyl)phenyl]-4-(furan-2-yl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1h-quinoline-3-carboxamide (417 Da, Ligand)
- Pentanoic acid (102 Da, Ligand)
- Scfv16 (31 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of FFAR3 complex bound with butyrate acid
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8j21
Q-score: 0.389
Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X, Wang J
Cell Res (2024) 34 pp. 323-326 [ Pubmed: 38191689 DOI: doi:10.1038/s41422-023-00914-z ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Butanoic acid (88 Da, Ligand)
- Free fatty acid receptor 3 (35 kDa, Protein from Homo sapiens)
- The ffar3 complex bound with butyrate acid (Complex from Homo sapiens)
- Scfv16 (31 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of FFAR2 complex bound with acetic acid
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8j24
Q-score: 0.545
Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X, Wang J
Cell Res (2024) 34 pp. 323-326 [ Pubmed: 38191689 DOI: doi:10.1038/s41422-023-00914-z ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 2 (35 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 2 complex (Complex from Homo sapiens)
- Scgv16 (31 kDa, Protein from Homo sapiens)
- Acetate ion (59 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
Lovastatin nonaketide synthase with LovC
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7cpy
Q-score: 0.306
Wang J, Liang J, Chen L, Zhang W, Kong L, Peng C, Su C, Tang Y, Deng Z, Wang Z
Nat Commun (2021) 12 pp. 867-867 [ DOI: doi:10.1038/s41467-021-21174-8 Pubmed: 33558520 ]
- Lovastatin nonaketide synthase, enoyl reductase component lovc (40 kDa, Protein from Aspergillus terreus)
- Lovastatin nonaketide synthase, polyketide synthase component (336 kDa, Protein from Aspergillus terreus)
- Nadp nicotinamide-adenine-dinucleotide phosphate (743 Da, Ligand)
- Lovc (Complex from Aspergillus terreus)
- Lovbc complex (750 MDa, Complex from Aspergillus terreus)
- Lovb (Complex)