Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Tamsulosin (408 Da, Ligand)
- Hexane (86 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8yvz
Q-score: 0.305
To Be Published
- Spike glycoprotein e1 (47 kDa, Protein from Semliki Forest virus 4)
- Capsid protein, partial (17 kDa, Protein from Semliki Forest virus 4)
- Spike glycoprotein e2 (46 kDa, Protein from Semliki Forest virus 4)
- Spike glycoprotein e3 (5 kDa, Protein from Semliki Forest virus 4)
- Very low-density lipoprotein receptor (4 kDa, Protein from Homo sapiens)
- Semliki forest virus viron in complex with vldlr-la3 (Cellular component from Semliki Forest virus 4)
- Calcium ion (40 Da, Ligand)
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 8yw0
Q-score: 0.225
To Be Published
- Spike glycoprotein e1 (47 kDa, Protein from Semliki Forest virus 4)
- Semliki forest virus viron in complex with vldlr-la5 (Cellular component from Semliki Forest virus 4)
- Spike glycoprotein e2 (46 kDa, Protein from Semliki Forest virus 4)
- Capsid protein, partial (17 kDa, Protein from Semliki Forest virus 4)
- Very low-density lipoprotein receptor (4 kDa, Protein from Homo sapiens)
- Spike glycoprotein e3 (5 kDa, Protein from Semliki Forest virus 4)
- Calcium ion (40 Da, Ligand)
Spo11 core complex with gapped DNA
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8urq
Q-score: 0.442
Yu Y, Wang J, Liu K, Zheng Z, Arter M, Claeys Bouuaert C, Pu S, Patel DJ, Keeney S
Nat Struct Mol Biol (2025) 32 pp. 113-124 [ Pubmed: 39304764 DOI: doi:10.1038/s41594-024-01382-8 ]
- Magnesium ion (24 Da, Ligand)
- Gapped dna (21 kDa, DNA from Saccharomyces cerevisiae S288C)
- Spo11 core complex bound to gapped dna (140 kDa, Complex from Saccharomyces cerevisiae S288C)
- Meiosis-specific protein spo11 (50 kDa, Protein from Saccharomyces cerevisiae S288C)
- Meiotic recombination protein rec102 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
- Antiviral protein ski8 (44 kDa, Protein from Saccharomyces cerevisiae S288C)
- Meiotic recombination protein rec104 (20 kDa, Protein from Saccharomyces cerevisiae S288C)
Spo11 core complex with hairpin DNA
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8uru
Q-score: 0.419
Yu Y, Wang J, Liu K, Zheng Z, Arter M, Claeys Bouuaert C, Pu S, Patel DJ, Keeney S
Nat Struct Mol Biol (2025) 32 pp. 113-124 [ Pubmed: 39304764 DOI: doi:10.1038/s41594-024-01382-8 ]
- Magnesium ion (24 Da, Ligand)
- Spo11 core complex bound to gapped dna (140 kDa, Complex from Saccharomyces cerevisiae S288C)
- Meiosis-specific protein spo11 (50 kDa, Protein from Saccharomyces cerevisiae S288C)
- Meiotic recombination protein rec102 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
- Meiotic recombination protein rec104 (20 kDa, Protein from Saccharomyces cerevisiae S288C)
- Hairpin dna (14 kDa, DNA from Saccharomyces cerevisiae S288C)
- Antiviral protein ski8 (44 kDa, Protein from Saccharomyces cerevisiae S288C)
Structure of AtHKT1;1 in NaCl at 2.7 Angstroms resolution
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8w9n
Q-score: 0.633
Wang J, Luo Y, Ye F, Ding ZJ, Zheng SJ, Qiao S, Wang Y, Guo J, Yang W, Su N
Mol Plant (2024) 17 pp. 409-422 [ Pubmed: 38335958 DOI: doi:10.1016/j.molp.2024.01.007 ]
- Sodium transporter hkt1 (57 kDa, Protein from Arabidopsis thaliana)
- Sodium ion (22 Da, Ligand)
- Structure of athkt1;1 in nacl at 2.7 angstroms resolution (Complex from Arabidopsis thaliana)
structure of AtHKT1;1 in KCl at 2.8 Angstroms resolution
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8w9o
Q-score: 0.589
Wang J, Luo Y, Ye F, Ding ZJ, Zheng SJ, Qiao S, Wang Y, Guo J, Yang W, Su N
Mol Plant (2024) 17 pp. 409-422 [ Pubmed: 38335958 DOI: doi:10.1016/j.molp.2024.01.007 ]
- Sodium transporter hkt1 (57 kDa, Protein from Arabidopsis thaliana)
- Structure of athkt1;1 in kcl at 2.8 angstroms resolution (Complex from Arabidopsis thaliana)
- Potassium ion (39 Da, Ligand)
Structure of TaHKT2;1 in NaCl at 2.6 Angstroms resolution
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8w9t
Q-score: 0.617
Wang J, Luo Y, Ye F, Ding ZJ, Zheng SJ, Qiao S, Wang Y, Guo J, Yang W, Su N
Mol Plant (2024) 17 pp. 409-422 [ Pubmed: 38335958 DOI: doi:10.1016/j.molp.2024.01.007 ]
- Structure of tahkt2;1 in nacl at 2.6 angstroms resolution (Complex from Arabidopsis thaliana)
- Hkt2 (60 kDa, Protein from Triticum aestivum)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
structure of TaHKT2;1 in KCl at 2.9 Angstroms resolution
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8w9v
Q-score: 0.598
Wang J, Luo Y, Ye F, Ding ZJ, Zheng SJ, Qiao S, Wang Y, Guo J, Yang W, Su N
Mol Plant (2024) 17 pp. 409-422 [ Pubmed: 38335958 DOI: doi:10.1016/j.molp.2024.01.007 ]
- Hkt2 (60 kDa, Protein from Triticum aestivum)
- Potassium ion (39 Da, Ligand)
- Structure of tahkt2;1 in kcl at 2.9 angstroms resolution (Complex from Arabidopsis thaliana)
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 7xxb
Q-score: 0.526
Su N, Zhu A, Tao X, Ding ZJ, Chang S, Ye F, Zhang Y, Zhao C, Chen Q, Wang J, Zhou CY, Guo Y, Jiao S, Zhang S, Wen H, Ma L, Ye S, Zheng SJ, Yang F, Wu S, Guo J
Nature (2022) 609 pp. 616-621 [ Pubmed: 35917926 DOI: doi:10.1038/s41586-022-05142-w ]
- Iaa-bound state atpin3(atpin3-iaa) (Complex from Arabidopsis thaliana)
- Auxin efflux carrier component 3 (73 kDa, Protein from Arabidopsis thaliana)
- 1h-indol-3-ylacetic acid (175 Da, Ligand)