Structure of native tri-heteromeric GluN1-GluN2A-GluN2B NMDA receptor in rat cortex and hippocampus
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8xlk
Q-score: 0.278
Zhang M, Feng J, Xie C, Song N, Jin C, Wang J, Zhao Q, Zhang L, Wang B, Sun Y, Guo F, Li Y, Zhu S
Cell (2025) [ DOI: doi:10.1016/j.cell.2025.01.004 Pubmed: 39855198 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of glun2b fab2 (28 kDa, Protein from Mus musculoides)
- Native tri-heteromeric glun1-glun2a-glun2b nmda receptor in rat cortex and hippocampus (Tissue from Rattus norvegicus)
- Glutamate receptor ionotropic, nmda 2a (165 kDa, Protein from Rattus norvegicus)
- Light chain of glun1 fab, 4f11 (13 kDa, Protein from Mus musculoides)
- Fab 4f11 (Complex)
- Glutamate receptor ionotropic, nmda 2b (166 kDa, Protein from Rattus norvegicus)
- Heavy chain of glun1 fab, 4f11 (15 kDa, Protein from Mus musculoides)
- (2r)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid (252 Da, Ligand)
- Fab (Complex from Mus musculoides)
- Fab 28c (Complex)
- Heavy chain of glun2b fab2 (26 kDa, Protein from Mus musculoides)
- Light chain of glun2a fab, 28c (22 kDa, Protein from Mus musculoides)
- Glutamate receptor ionotropic, nmda 1 (105 kDa, Protein from Rattus norvegicus)
- Heavy chain of glun2a fab, 28c (24 kDa, Protein from Mus musculoides)
- Fab2 (Complex)
- Nmda receptor (Complex)
Sarbecovirus BtKY72 Spike Trimer in a Locked Conformation
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8zy0
Q-score: 0.557
To Be Published
- Btky72/rhinolophus sp./kenya/2007 (420 kDa, Cellular component from BtKY72)
- Biliverdine ix alpha (582 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (132 kDa, Protein from Kenya bat coronavirus BtKY72)
Ra9479 Bat ACE2 Bound to BtKY72 Sarbecovirus Spike RBD (Focused Refinement)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8zy9
Q-score: 0.489
To Be Published
- Spike glycoprotein (24 kDa, Protein from Kenya bat coronavirus BtKY72)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Angiotensin-converting enzyme (86 kDa, Protein from Rhinolophus affinis)
- The complex of dimer bace2 with btky72 rbd (Cellular component from BtKY72)
Ra9479 Bat ACE2 Dimer in Complex with Two BtKY72 Sarbecovirus Spike RBDs
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8zya
Q-score: 0.551
To Be Published
- Spike glycoprotein (24 kDa, Protein from Kenya bat coronavirus BtKY72)
- Angiotensin-converting enzyme (92 kDa, Protein from Rhinolophus affinis)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- The complex of dimeric bace2 with btky72 rbd (Cellular component from BtKY72)
Structure of native di-heteromeric GluN1-GluN2B NMDA receptor in rat cortex and hippocampus
Resolution: 5.4 Å
EM Method: Single-particle
Fitted PDBs: 9jnn
Q-score: 0.183
Zhang M, Feng J, Xie C, Song N, Jin C, Wang J, Zhao Q, Zhang L, Wang B, Sun Y, Guo F, Li Y, Zhu S
Cell (2025) [ DOI: doi:10.1016/j.cell.2025.01.004 Pubmed: 39855198 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nmda receptor (Complex from Rattus norvegicus)
- Fab 4f11 (Complex)
- Heavy chain of glun2b fab2 (12 kDa, Protein from Mus musculus)
- Light chain of glun1 fab, 4f11 (11 kDa, Protein from Mus musculus)
- (2r)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid (252 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2b (91 kDa, Protein from Rattus norvegicus)
- Fab (Complex from Mus musculus)
- Glutamate receptor ionotropic, nmda 1 (91 kDa, Protein from Rattus norvegicus)
- Light chain of glun2b fab2 (11 kDa, Protein from Mus musculus)
- Native di-heteromeric glun1-glun2b nmda receptor in rat cortex and hippocampus (Tissue)
- Fab2 (Complex)
- Heavy chain of glun1 fab, 4f11 (13 kDa, Protein from Mus musculus)
Structure of rat beta-arrestin 1 by fiducial-assisted cryo-EM
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 9dng
Q-score: 0.431
Kahsai AW, Pakharukova N, Kwon HY, Shah KS, Liang-Lin JG, Del Real CT, Shim PJ, Lee MA, Ngo VA, Shreiber BN, Liu S, Schwalb AM, Espinoza EF, Thomas BN, Kunzle CA, Smith JS, Wang J, Kim J, Zhang X, Rockman HA, Thomsen ARB, Rein LAM, Shi L, Ahn S, Masoudi A, Lefkowitz RJ
bioRxiv (2024) [ Pubmed: 39763753 DOI: doi:10.1101/2024.12.27.630464 ]
- Anti-bril fab heavy chain (23 kDa, Protein from Homo sapiens)
- Beta-arrestin-1,soluble cytochrome b562 (55 kDa, Protein from Rattus norvegicus)
- Beta-arrestin 1 with insertion of soluble cytochrome b562 bound to anti-bril fab (Complex from Rattus norvegicus)
- Anti-bril fab light chain (23 kDa, Protein from Homo sapiens)
Structure of rat beta-arrestin 1 bound to allosteric inhibitor
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 9dnm
Q-score: 0.466
Kahsai AW, Pakharukova N, Kwon HY, Shah KS, Liang-Lin JG, Del Real CT, Shim PJ, Lee MA, Ngo VA, Shreiber BN, Liu S, Schwalb AM, Espinoza EF, Thomas BN, Kunzle CA, Smith JS, Wang J, Kim J, Zhang X, Rockman HA, Thomsen ARB, Rein LAM, Shi L, Ahn S, Masoudi A, Lefkowitz RJ
bioRxiv (2024) [ Pubmed: 39763753 DOI: doi:10.1101/2024.12.27.630464 ]
- Anti-bril fab heavy chain (23 kDa, Protein from Homo sapiens)
- Beta-arrestin-1,soluble cytochrome b562 (55 kDa, Protein from Rattus norvegicus)
- Anti-bril fab light chain (23 kDa, Protein from Homo sapiens)
- Beta-arrestin 1 with insertion of soluble cytochrome b562 bound to anti-bril fab (Complex from Rattus norvegicus)
- (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14r,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one (366 Da, Ligand)
Cryo-EM structure of human CMKLR1-Gi complex bound to chemerin
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8zjg
Q-score: 0.486
Commun Biol (2024) 7 pp. 1598-1598 [ Pubmed: 39616240 DOI: doi:10.1038/s42003-024-07228-9 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Vicugna pacos)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Chemerin-like receptor 1 (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Retinoic acid receptor responder protein 2 chemerinv (15 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Human chemerin receptor 1-gi complex bound to chemerin (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of human VMAT2 in complex with serotonin.
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 8x3k
Q-score: 0.553
Wei F, Liu H, Zhang W, Wang J, Zhang Y
Nat Commun (2025) 16 pp. 323-323 [ Pubmed: 39747030 DOI: doi:10.1038/s41467-024-55361-0 ]
- Soluble cytochrome b562,synaptic vesicular amine transporter (69 kDa, Protein from Homo sapiens)
- Vmat2 (Complex from Homo sapiens)
- Serotonin (176 Da, Ligand)
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 9dyh
Q-score: 0.476
Owji AP, Dong J, Kittredge A, Wang J, Zhang Y, Yang T
Nat Commun (2024) 15 pp. 10766-10766 [ Pubmed: 39737942 DOI: doi:10.1038/s41467-024-54938-z ]
- Bestrophin-2a (57 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Best2 + glutamate open state (286 kDa, Complex from Homo sapiens)