Cryo-EM structure of NRG1A(LRR) in complex with EDS1-SAG101-(ADPr-ATP)
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8yn1
Q-score: 0.561
Huang S, Wang J, Song R, Jia A, Xiao Y, Sun Y, Wang L, Mahr D, Wu Z, Han Z, Li X, Parker JE, Chai J
Nature (2025) [ Pubmed: 39939760 DOI: doi:10.1038/s41586-024-08521-7 ]
- Senescence-associated carboxylesterase 101 (61 kDa, Protein from Arabidopsis thaliana)
- Probable disease resistance protein at5g66900 (46 kDa, Protein from Arabidopsis thaliana)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Ternary complex of nrg1a(lrr) with eds1-sag101-(adpr-atp) (Complex from Arabidopsis)
- Adenosine-5-diphosphoribose (559 Da, Ligand)
- Protein eds1 (70 kDa, Protein from Arabidopsis thaliana)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8hj1
Q-score: 0.445
Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F
Nat Commun (2023) 14 pp. 216-216 [ DOI: doi:10.1038/s41467-023-35882-w Pubmed: 36639690 ]
- Nb35 (16 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (10 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 21 (39 kDa, Protein from Homo sapiens)
- Gpr21(wt) with gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8hix
Q-score: 0.489
Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F
Nat Commun (2023) 14 pp. 216-216 [ DOI: doi:10.1038/s41467-023-35882-w Pubmed: 36639690 ]
- Nb35 (16 kDa, Protein from Homo sapiens)
- Gpr21 and gs protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (10 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 21 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8hj2
Q-score: 0.425
Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F
Nat Commun (2023) 14 pp. 216-216 [ DOI: doi:10.1038/s41467-023-35882-w Pubmed: 36639690 ]
- Nb35 (16 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (10 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 21 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Gpr21(wt) with g15 (Complex from Homo sapiens)
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 8hj0
Q-score: 0.466
Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F
Nat Commun (2023) 14 pp. 216-216 [ DOI: doi:10.1038/s41467-023-35882-w Pubmed: 36639690 ]
- Nb35 (16 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (10 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (28 kDa, Protein from Homo sapiens)
- Gpr21 m5 with g15 (Complex from Homo sapiens)
- Probable g-protein coupled receptor 21 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of EDS1 and SAG101 with ATP-APDR
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 7xjp
Q-score: 0.488
Jia A, Huang S, Song W, Wang J, Meng Y, Sun Y, Xu L, Laessle H, Jirschitzka J, Hou J, Zhang T, Yu W, Hessler G, Li E, Ma S, Yu D, Gebauer J, Baumann U, Liu X, Han Z, Chang J, Parker JE, Chai J
Science (2022) 377 pp. eabq8180-eabq8180 [ DOI: doi:10.1126/science.abq8180 Pubmed: 35857644 ]
- Protein eds1 (71 kDa, Protein from Arabidopsis)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Isopropyl alcohol (60 Da, Ligand)
- Adenosine-5-diphosphoribose (559 Da, Ligand)
- Binary complex of eds1 and sag101 with molecule atp-adpr (Complex from Arabidopsis)
- Senescence-associated carboxylesterase 101 (62 kDa, Protein from Arabidopsis)
Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gi
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7f8v
Q-score: 0.436
Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q
Nat Chem Biol (2021) 17 pp. 1230-1237 [ Pubmed: 34556863 DOI: doi:10.1038/s41589-021-00866-8 ]
- Gastrin-17 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gastrin-17 (2 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-2 (40 kDa, Protein from Homo sapiens)
- Gastrin/cholecystokinin type b receptor (50 kDa, Protein from Homo sapiens)
- Cholecystokinin type b receptor (Complex)
- Cholecystokinin recetor cckbr in complex with gastrin-17 and gi (Complex from Homo sapiens)
Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gq
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7f8w
Q-score: 0.335
Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q
Nat Chem Biol (2021) 17 pp. 1230-1237 [ Pubmed: 34556863 DOI: doi:10.1038/s41589-021-00866-8 ]
- Gastrin-17 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gastrin-17 (2 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Gastrin/cholecystokinin type b receptor (50 kDa, Protein from Homo sapiens)
- Cholecystokinin type b receptor (Complex)
- Cholecystokinin recetor cckbr in complex with gastrin-17 and gq (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g subunits (Complex from Homo sapiens)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7e3k
Q-score: 0.298
Li T, Han X, Gu C, Guo H, Zhang H, Wang Y, Hu C, Wang K, Liu F, Luo F, Zhang Y, Hu J, Wang W, Li S, Hao Y, Shen M, Huang J, Long Y, Song S, Wu R, Mu S, Chen Q, Gao F, Wang J, Long S, Li L, Wu Y, Gao Y, Xu W, Cai X, Qu D, Zhang Z, Zhang H, Li N, Gao Q, Zhang G, He C, Wang W, Ji X, Tang N, Yuan Z, Xie Y, Yang H, Zhang B, Huang A, Jin A
Nat Commun (2021) 12 pp. 6304-6304 [ Pubmed: 34728625 DOI: doi:10.1038/s41467-021-26539-7 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 13g9 heavy chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Homo sapiens)
- Fab (Complex)
- Sars-cov-2 spike glycoprotein complex with 13g9 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- 13g9 light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7e3l
Q-score: 0.349
Li T, Han X, Gu C, Guo H, Zhang H, Wang Y, Hu C, Wang K, Liu F, Luo F, Zhang Y, Hu J, Wang W, Li S, Hao Y, Shen M, Huang J, Long Y, Song S, Wu R, Mu S, Chen Q, Gao F, Wang J, Long S, Li L, Wu Y, Gao Y, Xu W, Cai X, Qu D, Zhang Z, Zhang H, Li N, Gao Q, Zhang G, He C, Wang W, Ji X, Tang N, Yuan Z, Xie Y, Yang H, Zhang B, Huang A, Jin A
Nat Commun (2021) 12 pp. 6304-6304 [ Pubmed: 34728625 DOI: doi:10.1038/s41467-021-26539-7 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 58g6 heavy chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Homo sapiens)
- Fab (Complex)
- 58g6 light chain (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike glycoprotein complex with 58g6 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)