Cryo-EM structure of the METH-bound hTAAR1-Gs complex
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 9jkq
Q-score: 0.565
Lin Y, Wang J, Shi F, Yang L, Wu S, Qiao A, Ye S
J Med Chem (2024) 67 pp. 18593-18605 [ Pubmed: 39358311 DOI: doi:10.1021/acs.jmedchem.4c01961 ]
- Soluble cytochrome b562,trace amine-associated receptor 1 (57 kDa, Protein from Homo sapiens)
- Nb35 (17 kDa, Protein from Homo sapiens)
- (2s)-n-methyl-1-phenylpropan-2-amine (149 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Meth-bound htaar1-gs complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Complex of FMDV O/18074 and inter-serotype broadly neutralizing antibodies pOA-2
Resolution: 2.44 Å
EM Method: Single-particle
Fitted PDBs: 8y0q
Q-score: 0.621
Li F, Wu S, Lv L, Huang S, Zhang Z, Zerang Z, Li P, Cao Y, Bao H, Sun P, Bai X, He Y, Fu Y, Yuan H, Ma X, Zhao Z, Zhang J, Wang J, Wang T, Li D, Zhang Q, He J, Liu Z, Lu Z, Lei D, Li K
PLoS Pathog (2024) 20 pp. e1012623-e1012623 [ DOI: doi:10.1371/journal.ppat.1012623 Pubmed: 39405339 ]
- Inter-serotype broadly neutralizing antibodies poa-2 (Complex from Sus scrofa)
- Complex of fmdv o/18074 and inter-serotype broadly neutralizing antibodies poa-2 (Complex)
- Vp3 of capsid protein (23 kDa, Protein from Foot-and-mouth disease virus O)
- Vp1 of capsid protein (23 kDa, Protein from Foot-and-mouth disease virus O)
- Vp4 of capsid protein (8 kDa, Protein from Foot-and-mouth disease virus O)
- Poa2 vl (11 kDa, Protein from Sus scrofa)
- Vp2 of capsid protein (24 kDa, Protein from Foot-and-mouth disease virus O)
- Fmdv o/18074 (Complex from Foot-and-mouth disease virus O)
- Poa2 vh (13 kDa, Protein from Sus scrofa)
Complex of FMDV A/WH/CHA/09 and inter-serotype broadly neutralizing antibodies pOA-2
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 8y0r
Q-score: 0.578
Li F, Wu S, Lv L, Huang S, Zhang Z, Zerang Z, Li P, Cao Y, Bao H, Sun P, Bai X, He Y, Fu Y, Yuan H, Ma X, Zhao Z, Zhang J, Wang J, Wang T, Li D, Zhang Q, He J, Liu Z, Lu Z, Lei D, Li K
PLoS Pathog (2024) 20 pp. e1012623-e1012623 [ DOI: doi:10.1371/journal.ppat.1012623 Pubmed: 39405339 ]
- Inter-serotype broadly neutralizing antibodies poa-2 (Complex from Sus scrofa)
- Complex of fmdv a/wh/cha/09 and inter-serotype broadly neutralizing antibodies poa-2 (Complex)
- Vp2 of capsid protein (24 kDa, Protein from Foot-and-mouth disease virus A)
- Vp3 of capsid protein (24 kDa, Protein from Foot-and-mouth disease virus A)
- Fmdv a/wh/cha/09 (Complex from Foot-and-mouth disease virus A)
- Vp4 of capsid protein (8 kDa, Protein from Foot-and-mouth disease virus A)
- Vp1 of capsid protein (23 kDa, Protein from Foot-and-mouth disease virus A)
- Poa2 vl (11 kDa, Protein from Sus scrofa)
- Poa2 vh (13 kDa, Protein from Sus scrofa)
NTP-bound Pol IV transcription elongation complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8xmb
Q-score: 0.43
Fang C, Huang K, Wu X, Zhang H, Gu Z, Wang J, Zhang Y
Sci Adv (2024) 10 pp. eadq3087-eadq3087 [ DOI: doi:10.1126/sciadv.adq3087 Pubmed: 39178250 ]
- Dna-directed rna polymerases ii, iv and v subunit 10 (8 kDa, Protein from Arabidopsis thaliana)
- Template_dna (9 kDa, DNA from synthetic construct)
- Dna-directed rna polymerases iv and v subunit 4 (22 kDa, Protein from Arabidopsis thaliana)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerases ii, iv and v subunit 11 (13 kDa, Protein from Arabidopsis thaliana)
- Rna (4 kDa, RNA from synthetic construct)
- Dna-directed rna polymerases ii, iv and v subunit 9a (13 kDa, Protein from Arabidopsis thaliana)
- Rna-dependent rna polymerase 2 (129 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 8b (16 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 12 (5 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerase iv subunit 1 (168 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases iv and v subunit 2 (132 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerase iv subunit 7 (19 kDa, Protein from Arabidopsis thaliana)
- Zinc ion (65 Da, Ligand)
- Ntp-bound pol iv transcription elongation complex (650 kDa, Complex from Arabidopsis thaliana)
- Nontemplate_dna (6 kDa, DNA from synthetic construct)
- Dna-directed rna polymerases ii, iv and v subunit 3 (35 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii and iv subunit 5a (24 kDa, Protein from Arabidopsis thaliana)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Dna-directed rna polymerases ii, iv and v subunit 6a (16 kDa, Protein from Arabidopsis thaliana)
Post-translocated Pol IV transcription elongation complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8xmc
Q-score: 0.417
Fang C, Huang K, Wu X, Zhang H, Gu Z, Wang J, Zhang Y
Sci Adv (2024) 10 pp. eadq3087-eadq3087 [ DOI: doi:10.1126/sciadv.adq3087 Pubmed: 39178250 ]
- Dna-directed rna polymerases ii, iv and v subunit 10 (8 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases iv and v subunit 4 (22 kDa, Protein from Arabidopsis thaliana)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerases ii, iv and v subunit 11 (13 kDa, Protein from Arabidopsis thaliana)
- Rna (4 kDa, RNA from synthetic construct)
- Dna-directed rna polymerases ii, iv and v subunit 9a (13 kDa, Protein from Arabidopsis thaliana)
- Rna-dependent rna polymerase 2 (129 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 8b (16 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 12 (5 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerase iv subunit 1 (168 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases iv and v subunit 2 (132 kDa, Protein from Arabidopsis thaliana)
- Post-translocated pol iv transcription elongation complex (650 kDa, Complex from Arabidopsis thaliana)
- Dna-directed rna polymerase iv subunit 7 (19 kDa, Protein from Arabidopsis thaliana)
- Zinc ion (65 Da, Ligand)
- Dna-directed rna polymerases ii, iv and v subunit 3 (35 kDa, Protein from Arabidopsis thaliana)
- Template dna (9 kDa, DNA from synthetic construct)
- Dna-directed rna polymerases ii and iv subunit 5a (24 kDa, Protein from Arabidopsis thaliana)
- Non-template dna (6 kDa, DNA from synthetic construct)
- Dna-directed rna polymerases ii, iv and v subunit 6a (16 kDa, Protein from Arabidopsis thaliana)
Pre-translocated Pol IV transcription elongation complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8xmd
Q-score: 0.383
Fang C, Huang K, Wu X, Zhang H, Gu Z, Wang J, Zhang Y
Sci Adv (2024) 10 pp. eadq3087-eadq3087 [ DOI: doi:10.1126/sciadv.adq3087 Pubmed: 39178250 ]
- Pre-translocated pol iv transcription elongation complex (650 kDa, Complex from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 10 (8 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases iv and v subunit 4 (22 kDa, Protein from Arabidopsis thaliana)
- Rna (5 kDa, RNA from synthetic construct)
- Magnesium ion (24 Da, Ligand)
- Template_dna (10 kDa, DNA from synthetic construct)
- Dna-directed rna polymerases ii, iv and v subunit 11 (13 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 9a (13 kDa, Protein from Arabidopsis thaliana)
- Rna-dependent rna polymerase 2 (129 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 8b (16 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 12 (5 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerase iv subunit 1 (168 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases iv and v subunit 2 (132 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerase iv subunit 7 (19 kDa, Protein from Arabidopsis thaliana)
- Zinc ion (65 Da, Ligand)
- Nontemplate_dna (6 kDa, DNA from synthetic construct)
- Dna-directed rna polymerases ii, iv and v subunit 3 (35 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii and iv subunit 5a (24 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 6a (16 kDa, Protein from Arabidopsis thaliana)
Backtracked Pol IV transcription elongation complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8xme
Q-score: 0.377
Fang C, Huang K, Wu X, Zhang H, Gu Z, Wang J, Zhang Y
Sci Adv (2024) 10 pp. eadq3087-eadq3087 [ DOI: doi:10.1126/sciadv.adq3087 Pubmed: 39178250 ]
- Dna-directed rna polymerases ii, iv and v subunit 10 (8 kDa, Protein from Arabidopsis thaliana)
- Backtracked pol iv transcription elongation complex (650 kDa, Complex from Arabidopsis thaliana)
- Dna-directed rna polymerases iv and v subunit 4 (22 kDa, Protein from Arabidopsis thaliana)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerases ii, iv and v subunit 11 (13 kDa, Protein from Arabidopsis thaliana)
- Rna (5 kDa, RNA from synthetic construct)
- Dna-directed rna polymerases ii, iv and v subunit 9a (13 kDa, Protein from Arabidopsis thaliana)
- Rna-dependent rna polymerase 2 (129 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 8b (16 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases ii, iv and v subunit 12 (5 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerase iv subunit 1 (168 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerases iv and v subunit 2 (132 kDa, Protein from Arabidopsis thaliana)
- Dna-directed rna polymerase iv subunit 7 (19 kDa, Protein from Arabidopsis thaliana)
- Zinc ion (65 Da, Ligand)
- Dna-directed rna polymerases ii, iv and v subunit 3 (35 kDa, Protein from Arabidopsis thaliana)
- Template_dna (12 kDa, DNA from synthetic construct)
- Dna-directed rna polymerases ii and iv subunit 5a (24 kDa, Protein from Arabidopsis thaliana)
- Nontemplate_dna (12 kDa, DNA from synthetic construct)
- Dna-directed rna polymerases ii, iv and v subunit 6a (16 kDa, Protein from Arabidopsis thaliana)
mycobacterial efflux pump, apo state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8k1m
Q-score: 0.574
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L
PNAS (2024) 121 pp. e2403421121-e2403421121 [ Pubmed: 39226350 DOI: doi:10.1073/pnas.2403421121 ]
- Multidrug efflux system permease protein rv1217c (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Cardiolipin (1 kDa, Ligand)
- Ternary complex of an abc transporter rv1217c-1218c (120 kDa, Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- (1s)-2-{[(s)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9z)-octadec-9-enoate (746 Da, Ligand)
- Multidrug efflux system atp-binding protein rv1218c (31 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
mycobacterial efflux pump, substrate-bound state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8k1n
Q-score: 0.541
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L
PNAS (2024) 121 pp. e2403421121-e2403421121 [ Pubmed: 39226350 DOI: doi:10.1073/pnas.2403421121 ]
- Multidrug efflux system permease protein rv1217c (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Multidrug efflux system atp-binding protein rv1218c (33 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Rifampicin (822 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Ternary complex of an abc transporter rv1217c-1218c (120 kDa, Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
mycobacterial efflux pump, AMPPNP bound state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8k1o
Q-score: 0.597
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L
PNAS (2024) 121 pp. e2403421121-e2403421121 [ Pubmed: 39226350 DOI: doi:10.1073/pnas.2403421121 ]
- Multidrug efflux system permease protein rv1217c (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Multidrug efflux system atp-binding protein rv1218c (33 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Cardiolipin (1 kDa, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Ternary complex of an abc transporter rv1217c-1218c (120 kDa, Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))