Structure of human TRPV1 in complex with antagonist
Fan J, Ke H, Lei J, Wang J, Tominaga M, Lei X
Nat Commun (2024) 15 pp. 6689-6689 [ Pubmed: 39107321 DOI: doi:10.1038/s41467-024-51085-3 ]
- Cholesterol (386 Da, Ligand)
- Trpv1 (360 kDa, Complex from Homo sapiens)
- 4-(7-hydroxy-2-isopropyl-4-oxoquinazolin-3(4h)-yl)benzonitrile (305 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 1,prescission site,green fluorescent protein (125 kDa, Protein from Pseudotevenvirus RB43)
Structure of human TRPV1 in complex with antagonist --protein purified without CHS
Fan J, Ke H, Lei J, Wang J, Tominaga M, Lei X
Nat Commun (2024) 15 pp. 6689-6689 [ Pubmed: 39107321 DOI: doi:10.1038/s41467-024-51085-3 ]
- Cholesterol (386 Da, Ligand)
- Transient receptor potential cation channel subfamily v member 1,green fluorescent protein (125 kDa, Protein from synthetic construct)
- Trpv1 (360 kDa, Complex from Homo sapiens)
- 4-(7-hydroxy-2-isopropyl-4-oxoquinazolin-3(4h)-yl)benzonitrile (305 Da, Ligand)
Cryo-EM structure of apo-state huamn angiotensin-converting enzyme 2 (ACE2)
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 8jwh
Q-score: 0.46
Yang Z, Fan J, Wang J, Fan X, Ouyang Z, Wang HW, Zhou X
Nat Methods (2024) 21 pp. 1023-1032 [ Pubmed: 38664529 DOI: doi:10.1038/s41592-024-02247-0 ]
- Human angiotensin-converting enzyme 2 (ace2) (70 MDa, Complex from Homo sapiens)
- Processed angiotensin-converting enzyme 2 (69 kDa, Protein from Homo sapiens)
Cryo-EM structure of human disease-associated P301L Tau amyloid fibril from mouse brain
Resolution: 3.28 Å
EM Method: Helical reconstruction
Fitted PDBs: 8wcp
Q-score: 0.568
Zhao W, Liu K, Fan Y, Zhao Q, Tao Y, Zhang M, Gan L, Yu W, Sun B, Li D, Liu C, Wang J
Cell Discov (2024) 10 pp. 27-27 [ DOI: doi:10.1038/s41421-023-00637-w Pubmed: 38448404 ]
- Island a (783 Da, Protein from Mus musculus)
- P301l tau amyloid fibril from rtg4510 mice (40 kDa, Protein from Mus musculus)
- Tau (Tissue from Mus musculus)
- Island b (869 Da, Protein from Mus musculus)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8e56
Q-score: 0.54
Yao X, Gao S, Wang J, Li Z, Huang J, Wang Y, Wang Z, Chen J, Fan X, Wang W, Jin X, Pan X, Yu Y, Lagrutta A, Yan N
Cell (2022) 185 pp. 4801-4810.e13 [ Pubmed: 36417914 DOI: doi:10.1016/j.cell.2022.10.024 ]
- (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone (645 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (125 kDa, Protein from Oryctolagus cuniculus)
- Cav1.1 (Complex from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8e57
Q-score: 0.534
Yao X, Gao S, Wang J, Li Z, Huang J, Wang Y, Wang Z, Chen J, Fan X, Wang W, Jin X, Pan X, Yu Y, Lagrutta A, Yan N
Cell (2022) 185 pp. 4801-4810.e13 [ Pubmed: 36417914 DOI: doi:10.1016/j.cell.2022.10.024 ]
- (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone (645 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (125 kDa, Protein from Oryctolagus cuniculus)
- Propan-2-yl (2s)-2-{[(s)-{[(2r,3s,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-4-ethynyl-3-hydroxy-4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate (non-preferred name) (535 Da, Ligand)
- Cav1.1 (Complex from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8e58
Q-score: 0.533
Yao X, Gao S, Wang J, Li Z, Huang J, Wang Y, Wang Z, Chen J, Fan X, Wang W, Jin X, Pan X, Yu Y, Lagrutta A, Yan N
Cell (2022) 185 pp. 4801-4810.e13 [ Pubmed: 36417914 DOI: doi:10.1016/j.cell.2022.10.024 ]
- (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone (645 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit alpha-1s (212 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent calcium channel gamma-1 subunit (25 kDa, Protein from Oryctolagus cuniculus)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (125 kDa, Protein from Oryctolagus cuniculus)
- Propan-2-yl (2s)-2-{[(s)-{[(2r,3s,4r,5r)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2h)-yl)-4-ethynyl-3-hydroxy-4-methyloxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate (non-preferred name) (535 Da, Ligand)
- Cav1.1 (Complex from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8e59
Q-score: 0.446
Yao X, Gao S, Wang J, Li Z, Huang J, Wang Y, Wang Z, Chen J, Fan X, Wang W, Jin X, Pan X, Yu Y, Lagrutta A, Yan N
Cell (2022) 185 pp. 4801-4810.e13 [ Pubmed: 36417914 DOI: doi:10.1016/j.cell.2022.10.024 ]
- (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone (645 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit alpha-1d (245 kDa, Protein from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Cav1.3 (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8e5a
Q-score: 0.423
Yao X, Gao S, Wang J, Li Z, Huang J, Wang Y, Wang Z, Chen J, Fan X, Wang W, Jin X, Pan X, Yu Y, Lagrutta A, Yan N
Cell (2022) 185 pp. 4801-4810.e13 [ Pubmed: 36417914 DOI: doi:10.1016/j.cell.2022.10.024 ]
- Voltage-dependent l-type calcium channel subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit alpha-1d (245 kDa, Protein from Homo sapiens)
- Cav1.3 (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8e5b
Q-score: 0.467
Yao X, Gao S, Wang J, Li Z, Huang J, Wang Y, Wang Z, Chen J, Fan X, Wang W, Jin X, Pan X, Yu Y, Lagrutta A, Yan N
Cell (2022) 185 pp. 4801-4810.e13 [ Pubmed: 36417914 DOI: doi:10.1016/j.cell.2022.10.024 ]
- (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone (645 Da, Ligand)
- Voltage-dependent l-type calcium channel subunit beta-3 (54 kDa, Protein from Homo sapiens)
- Voltage-dependent calcium channel subunit alpha-2/delta-1 (124 kDa, Protein from Homo sapiens)
- Voltage-dependent l-type calcium channel subunit alpha-1d (245 kDa, Protein from Homo sapiens)
- Sofosbuvir (529 Da, Ligand)
- Cav1.3 (Complex from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)