Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Tamsulosin (408 Da, Ligand)
- Hexane (86 Da, Ligand)
- Tetradecane (198 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8yvz
Q-score: 0.305
To Be Published
- Spike glycoprotein e1 (47 kDa, Protein from Semliki Forest virus 4)
- Capsid protein, partial (17 kDa, Protein from Semliki Forest virus 4)
- Spike glycoprotein e2 (46 kDa, Protein from Semliki Forest virus 4)
- Spike glycoprotein e3 (5 kDa, Protein from Semliki Forest virus 4)
- Very low-density lipoprotein receptor (4 kDa, Protein from Homo sapiens)
- Semliki forest virus viron in complex with vldlr-la3 (Cellular component from Semliki Forest virus 4)
- Calcium ion (40 Da, Ligand)
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 8yw0
Q-score: 0.225
To Be Published
- Spike glycoprotein e1 (47 kDa, Protein from Semliki Forest virus 4)
- Semliki forest virus viron in complex with vldlr-la5 (Cellular component from Semliki Forest virus 4)
- Spike glycoprotein e2 (46 kDa, Protein from Semliki Forest virus 4)
- Capsid protein, partial (17 kDa, Protein from Semliki Forest virus 4)
- Very low-density lipoprotein receptor (4 kDa, Protein from Homo sapiens)
- Spike glycoprotein e3 (5 kDa, Protein from Semliki Forest virus 4)
- Calcium ion (40 Da, Ligand)
Semliki Forest virus viron in complex with VLDLR
Resolution: 3.44 Å
EM Method: Single-particle
Fitted PDBs: 8yw1
Q-score: 0.437
To Be Published
- Spike glycoprotein e1 (47 kDa, Protein from Semliki Forest virus 4)
- Capsid protein, partial (17 kDa, Protein from Semliki Forest virus 4)
- Spike glycoprotein e2 (46 kDa, Protein from Semliki Forest virus 4)
- Very low-density lipoprotein receptor (13 kDa, Protein from Homo sapiens)
- Semliki forest virus viron in complex with vldlr-la3-5 (Cellular component from Semliki Forest virus 4)
- Spike glycoprotein e3 (5 kDa, Protein from Semliki Forest virus 4)
Semliki Forest virus viron in complex with VLDLR
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8yw2
Q-score: 0.467
To Be Published
- Spike glycoprotein e1 (47 kDa, Protein from Semliki Forest virus 4)
- Capsid protein, partial (17 kDa, Protein from Semliki Forest virus 4)
- Spike glycoprotein e2 (46 kDa, Protein from Semliki Forest virus 4)
- Very low-density lipoprotein receptor (17 kDa, Protein from Homo sapiens)
- Spike glycoprotein e3 (5 kDa, Protein from Semliki Forest virus 4)
- Semliki forest viron (Complex from Semliki Forest virus 4)
ASFV p72 in complex with Fab G6
Resolution: 4.36 Å
EM Method: Single-particle
Fitted PDBs: 8zl9
Q-score: 0.253
Yu Q, Liang D, Fu W, Zhang L, Wang J, Zhang Z, Sun Y, Zhu D, Zheng B, Zhu L, Xiang Y, Zhao D, Wang X
Cell Discov (2024) 10 pp. 80-80 [ Pubmed: 39080252 DOI: doi:10.1038/s41421-024-00692-x ]
- G6 heavy chain (13 kDa, Protein from Sus scrofa)
- B646l (78 kDa, Protein from African swine fever virus)
- Asfv p72 in complex with fab g6 (Complex from African swine fever virus)
- G6 light chain (12 kDa, Protein from Sus scrofa)
ASFV p72 in complex with Fab B1
Yu Q, Liang D, Fu W, Zhang L, Wang J, Zhang Z, Sun Y, Zhu D, Zheng B, Zhu L, Xiang Y, Zhao D, Wang X
Cell Discov (2024) 10 pp. 80-80 [ Pubmed: 39080252 DOI: doi:10.1038/s41421-024-00692-x ]
- B646l (78 kDa, Protein from African swine fever virus)
- Heavy chain of b1 (12 kDa, Protein from Sus scrofa)
- Light chain of b1 (12 kDa, Protein from Sus scrofa)
- Asfv p72 in complex with fab b1 (Complex from African swine fever virus)
ASFV p72 in complex with Fab C9
Yu Q, Liang D, Fu W, Zhang L, Wang J, Zhang Z, Sun Y, Zhu D, Zheng B, Zhu L, Xiang Y, Zhao D, Wang X
Cell Discov (2024) 10 pp. 80-80 [ Pubmed: 39080252 DOI: doi:10.1038/s41421-024-00692-x ]
- B646l (78 kDa, Protein from African swine fever virus)
- Heavy chain of c9 (13 kDa, Protein from Sus scrofa)
- Asfv p72 in complex with fab c9 (Complex from African swine fever virus)
- Light chain of c9 (11 kDa, Protein from Sus scrofa)
ASFV p72 in complex with Fab F11
Yu Q, Liang D, Fu W, Zhang L, Wang J, Zhang Z, Sun Y, Zhu D, Zheng B, Zhu L, Xiang Y, Zhao D, Wang X
Cell Discov (2024) 10 pp. 80-80 [ Pubmed: 39080252 DOI: doi:10.1038/s41421-024-00692-x ]
- B646l (78 kDa, Protein from African swine fever virus)
- Heavy chain of f11 (13 kDa, Protein from Sus scrofa)
- Light chain of f11 (11 kDa, Protein from Sus scrofa)
- Asfv p72 in complex with fab f11 (Complex from African swine fever virus)
ASFV p72 in complex with Fab H3
Yu Q, Liang D, Fu W, Zhang L, Wang J, Zhang Z, Sun Y, Zhu D, Zheng B, Zhu L, Xiang Y, Zhao D, Wang X
Cell Discov (2024) 10 pp. 80-80 [ Pubmed: 39080252 DOI: doi:10.1038/s41421-024-00692-x ]
- B646l (78 kDa, Protein from African swine fever virus)
- Heavy chain of h3 (13 kDa, Protein from Sus scrofa)
- Asfv p72 in complex with fab h3 (Complex from African swine fever virus)
- Light chain of h3 (11 kDa, Protein from Sus scrofa)