Cryo-EM structure of Ca2+-bound TMEM16A in complex with Tamsulosin
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 8xlr
Q-score: 0.527
Li S, Sun W, Li S, Zhu L, Guo S, He J, Li Y, Tian C, Zhao Z, Yu T, Li J, Zhang Y, Hai Y, Wang J, Zheng Y, Wang R, Hu X, Ling S, Li H, Li Y
PNAS (2025) 122 pp. e2407493121-e2407493121 [ Pubmed: 39739807 DOI: doi:10.1073/pnas.2407493121 ]
- Structure of tamsulosin- and calcium-bound mtmem16a chloride channel (Complex from Mus musculus)
- Tetradecane (198 Da, Ligand)
- Hexane (86 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Anoctamin-1 (111 kDa, Protein from Mus musculus)
- Tamsulosin (408 Da, Ligand)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8yvz
Q-score: 0.305
To Be Published
- Semliki forest virus viron in complex with vldlr-la3 (Cellular component from Semliki Forest virus 4)
- Calcium ion (40 Da, Ligand)
- Spike glycoprotein e1 (47 kDa, Protein from Semliki Forest virus 4)
- Spike glycoprotein e2 (46 kDa, Protein from Semliki Forest virus 4)
- Spike glycoprotein e3 (5 kDa, Protein from Semliki Forest virus 4)
- Very low-density lipoprotein receptor (4 kDa, Protein from Homo sapiens)
- Capsid protein, partial (17 kDa, Protein from Semliki Forest virus 4)
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 8yw0
Q-score: 0.225
To Be Published
- Calcium ion (40 Da, Ligand)
- Spike glycoprotein e1 (47 kDa, Protein from Semliki Forest virus 4)
- Spike glycoprotein e2 (46 kDa, Protein from Semliki Forest virus 4)
- Very low-density lipoprotein receptor (4 kDa, Protein from Homo sapiens)
- Spike glycoprotein e3 (5 kDa, Protein from Semliki Forest virus 4)
- Capsid protein, partial (17 kDa, Protein from Semliki Forest virus 4)
- Semliki forest virus viron in complex with vldlr-la5 (Cellular component from Semliki Forest virus 4)
Semliki Forest virus viron in complex with VLDLR
Resolution: 3.44 Å
EM Method: Single-particle
Fitted PDBs: 8yw1
Q-score: 0.437
To Be Published
- Very low-density lipoprotein receptor (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein e1 (47 kDa, Protein from Semliki Forest virus 4)
- Spike glycoprotein e2 (46 kDa, Protein from Semliki Forest virus 4)
- Semliki forest virus viron in complex with vldlr-la3-5 (Cellular component from Semliki Forest virus 4)
- Spike glycoprotein e3 (5 kDa, Protein from Semliki Forest virus 4)
- Capsid protein, partial (17 kDa, Protein from Semliki Forest virus 4)
Semliki Forest virus viron in complex with VLDLR
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8yw2
Q-score: 0.467
To Be Published
- Spike glycoprotein e1 (47 kDa, Protein from Semliki Forest virus 4)
- Spike glycoprotein e2 (46 kDa, Protein from Semliki Forest virus 4)
- Spike glycoprotein e3 (5 kDa, Protein from Semliki Forest virus 4)
- Capsid protein, partial (17 kDa, Protein from Semliki Forest virus 4)
- Very low-density lipoprotein receptor (17 kDa, Protein from Homo sapiens)
- Semliki forest viron (Complex from Semliki Forest virus 4)
SARS-CoV-2 S1 in complex with H18 and R1-32 Fab
Yan Q, Gao X, Liu B, Hou R, He P, Ma Y, Zhang Y, Zhang Y, Li Z, Chen Q, Wang J, Huang X, Liang H, Zheng H, Yao Y, Chen X, Niu X, He J, Chen L, Zhao J, Xiong X
Nat Commun (2024) 15 pp. 7585-7585 [ DOI: doi:10.1038/s41467-024-51770-3 Pubmed: 39217172 ]
- Sars-cov-2 s1 in complex with h18 and r1-32 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of h18 fab (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
- Light chain of h18 fab (25 kDa, Protein from Homo sapiens)
- H18 fab (Complex from Homo sapiens)
- Spike glycoprotein (74 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 s1 (Complex from Severe acute respiratory syndrome coronavirus 2)
- R1-32 fab (Complex from Homo sapiens)
Dimer of SARS-CoV-2 S1 in complex with H18 and R1-32 Fabs
Yan Q, Gao X, Liu B, Hou R, He P, Ma Y, Zhang Y, Zhang Y, Li Z, Chen Q, Wang J, Huang X, Liang H, Zheng H, Yao Y, Chen X, Niu X, He J, Chen L, Zhao J, Xiong X
Nat Commun (2024) 15 pp. 7585-7585 [ DOI: doi:10.1038/s41467-024-51770-3 Pubmed: 39217172 ]
- Heavy chain of h18 fab (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Light chain of r1-32 fab (22 kDa, Protein from Homo sapiens)
- Dimer of sars-cov-2 s1 in complex with h18 and r1-32 fabs (Complex from Severe acute respiratory syndrome coronavirus 2)
- H18 fab (Complex from Homo sapiens)
- Light chain of h18 fab (25 kDa, Protein from Homo sapiens)
- Spike glycoprotein (74 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of r1-32 fab (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 s1 (Complex from Severe acute respiratory syndrome coronavirus 2)
- R1-32 fab (Complex from Homo sapiens)
Spo11 core complex with gapped DNA
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8urq
Q-score: 0.442
Yu Y, Wang J, Liu K, Zheng Z, Arter M, Claeys Bouuaert C, Pu S, Patel DJ, Keeney S
Nat Struct Mol Biol (2025) 32 pp. 113-124 [ DOI: doi:10.1038/s41594-024-01382-8 Pubmed: 39304764 ]
- Meiosis-specific protein spo11 (50 kDa, Protein from Saccharomyces cerevisiae S288C)
- Meiotic recombination protein rec102 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
- Meiotic recombination protein rec104 (20 kDa, Protein from Saccharomyces cerevisiae S288C)
- Gapped dna (21 kDa, DNA from Saccharomyces cerevisiae S288C)
- Spo11 core complex bound to gapped dna (140 kDa, Complex from Saccharomyces cerevisiae S288C)
- Magnesium ion (24 Da, Ligand)
- Antiviral protein ski8 (44 kDa, Protein from Saccharomyces cerevisiae S288C)
Spo11 core complex with hairpin DNA
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 8uru
Q-score: 0.419
Yu Y, Wang J, Liu K, Zheng Z, Arter M, Claeys Bouuaert C, Pu S, Patel DJ, Keeney S
Nat Struct Mol Biol (2025) 32 pp. 113-124 [ DOI: doi:10.1038/s41594-024-01382-8 Pubmed: 39304764 ]
- Meiosis-specific protein spo11 (50 kDa, Protein from Saccharomyces cerevisiae S288C)
- Hairpin dna (14 kDa, DNA from Saccharomyces cerevisiae S288C)
- Antiviral protein ski8 (44 kDa, Protein from Saccharomyces cerevisiae S288C)
- Spo11 core complex bound to gapped dna (140 kDa, Complex from Saccharomyces cerevisiae S288C)
- Magnesium ion (24 Da, Ligand)
- Meiotic recombination protein rec104 (20 kDa, Protein from Saccharomyces cerevisiae S288C)
- Meiotic recombination protein rec102 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
Structure of AtHKT1;1 in NaCl at 2.7 Angstroms resolution
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8w9n
Q-score: 0.633
Wang J, Luo Y, Ye F, Ding ZJ, Zheng SJ, Qiao S, Wang Y, Guo J, Yang W, Su N
Mol Plant (2024) 17 pp. 409-422 [ DOI: doi:10.1016/j.molp.2024.01.007 Pubmed: 38335958 ]
- Sodium ion (22 Da, Ligand)
- Structure of athkt1;1 in nacl at 2.7 angstroms resolution (Complex from Arabidopsis thaliana)
- Sodium transporter hkt1 (57 kDa, Protein from Arabidopsis thaliana)