Cryo-EM structure of the xGPR4-Gs complex in pH6.2
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8zd1
Q-score: 0.567
Wen X, Shang P, Chen H, Guo L, Rong N, Jiang X, Li X, Liu J, Yang G, Zhang J, Zhu K, Meng Q, He X, Wang Z, Liu Z, Cheng H, Zheng Y, Zhang B, Pang J, Liu Z, Xiao P, Chen Y, Liu L, Luo F, Yu X, Yi F, Zhang P, Yang F, Deng C, Sun JP
Cell (2025) 188 pp. 653-670.e24 [ Pubmed: 39753131 DOI: doi:10.1016/j.cell.2024.12.001 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Cryo-em structure of the xgpr4-gs complex in ph6.2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (5 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- G-protein coupled receptor 4 (31 kDa, Protein from Xenopus tropicalis)
Cryo-EM structure of the receptor of xtGPR4-Gs complex in pH7.2
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 8zfb
Q-score: 0.433
Wen X, Shang P, Chen H, Guo L, Rong N, Jiang X, Li X, Liu J, Yang G, Zhang J, Zhu K, Meng Q, He X, Wang Z, Liu Z, Cheng H, Zheng Y, Zhang B, Pang J, Liu Z, Xiao P, Chen Y, Liu L, Luo F, Yu X, Yi F, Zhang P, Yang F, Deng C, Sun JP
Cell (2025) 188 pp. 653-670.e24 [ Pubmed: 39753131 DOI: doi:10.1016/j.cell.2024.12.001 ]
Cryo-EM structure of the receptor of xGPR4-apo in pH8.0
Resolution: 2.36 Å
EM Method: Single-particle
Fitted PDBs: 9jvm
Q-score: 0.393
Wen X, Shang P, Chen H, Guo L, Rong N, Jiang X, Li X, Liu J, Yang G, Zhang J, Zhu K, Meng Q, He X, Wang Z, Liu Z, Cheng H, Zheng Y, Zhang B, Pang J, Liu Z, Xiao P, Chen Y, Liu L, Luo F, Yu X, Yi F, Zhang P, Yang F, Deng C, Sun JP
Cell (2025) 188 pp. 653-670.e24 [ Pubmed: 39753131 DOI: doi:10.1016/j.cell.2024.12.001 ]
Versatile Aromatic Prenyltransferase auraA mutant-Y207A in complex with DMSPP
EDS1-SAG101-NRG1A L134E heterotrimer
Xiao Y, Wu X, Wang Z, Ji K, Zhao Y, Zhang Y, Wan L
Nature (2025) [ DOI: doi:10.1038/s41586-024-08517-3 Pubmed: 39939758 ]
- Eds1-sag101-nrg1a l134e heterotrimer (Complex from Arabidopsis thaliana)
- Probable disease resistance protein at5g66900 (92 kDa, Protein from Arabidopsis thaliana)
- [[(2~{r},3~{r},4~{r},5~{r})-5-(6-aminopurin-9-yl)-4-[(2~{s},3~{r},4~{s},5~{r})-5-[[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate (1 kDa, Ligand)
- Senescence-associated carboxylesterase 101 (62 kDa, Protein from Arabidopsis thaliana)
- Protein eds1 (71 kDa, Protein from Arabidopsis thaliana)
EDS1-SAG101-NRG1C heterotrimer
Xiao Y, Wu X, Wang Z, Ji K, Zhao Y, Zhang Y, Wan L
Nature (2025) [ DOI: doi:10.1038/s41586-024-08517-3 Pubmed: 39939758 ]
- [[(2~{r},3~{r},4~{r},5~{r})-5-(6-aminopurin-9-yl)-4-[(2~{s},3~{r},4~{s},5~{r})-5-[[[[(2~{r},3~{s},4~{r},5~{r})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]oxy-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate (1 kDa, Ligand)
- Senescence-associated carboxylesterase 101 (62 kDa, Protein from Arabidopsis thaliana)
- Probable disease resistance protein at5g66890 (47 kDa, Protein from Arabidopsis thaliana)
- Eds1-sag101-nrg1c heterotrimer (Complex from Arabidopsis thaliana)
- Protein eds1 (71 kDa, Protein from Arabidopsis thaliana)
Cryo-EM structure of neutralizing antibody 8G3 in complex with BA.1 RBD
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 9js4
Q-score: 0.434
Liao Y, Ma H, Wang Z, Wang S, He Y, Chang Y, Zong H, Tang H, Wang L, Ke Y, Cai H, Li P, Tang J, Chen H, Drelich A, Peng BH, Hsu J, Tat V, Tseng CK, Song J, Yuan Y, Wu M, Liu J, Yue Y, Zhang X, Wang Z, Yang L, Li J, Ni X, Li H, Xiang Y, Bian Y, Zhang B, Yin H, Dimitrov DS, Gilly J, Han L, Jiang H, Xie Y, Zhu J
PNAS (2025) 122 pp. e2406659122-e2406659122 [ Pubmed: 39908098 DOI: doi:10.1073/pnas.2406659122 ]
- Cryo-em structure of neutralizing antibody 8g3 in complex with ba.1 rbd (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (137 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Heavy chain of 8g3 (23 kDa, Protein from Homo heidelbergensis)
- Light chain of 8g3 (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of the Pseudomonas aeruginosa PAO1 Type IV pilus
Resolution: 3.17 Å
EM Method: Helical reconstruction
Fitted PDBs: 9ewx
Q-score: 0.57
Ochner H, Bohning J, Wang Z, Tarafder AK, Caspy I, Bharat TAM
PLoS Pathog (2024) 20 pp. e1012773-e1012773 [ Pubmed: 39666767 DOI: doi:10.1371/journal.ppat.1012773 ]
- Pilin (14 kDa, Protein from Pseudomonas aeruginosa)
- Pseudomonas aeruginosa pao1 type iv pilus (15 kDa, Complex from Pseudomonas aeruginosa)
CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-7909 binding at an allosteric site
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8w9a
Q-score: 0.591
Huang X, Wang K, Han J, Chen X, Wang Z, Wu T, Yu B, Zhao F, Wang X, Li H, Xie Z, Zhu X, Zhong W, Ren X
Structure (2024) 32 pp. 907-917.e7 [ Pubmed: 38582077 DOI: doi:10.1016/j.str.2024.03.007 ]
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (124 kDa, Protein from Homo sapiens)
- 6-chloranyl-3-[[(1r)-1-[2-(1,3-dihydropyrrolo[3,4-c]pyridin-2-yl)-3,6-dimethyl-4-oxidanylidene-quinazolin-8-yl]ethyl]amino]pyridine-2-carboxylic acid (490 Da, Ligand)
- Phosphatidylinositol 3-kinase regulatory subunit alpha (83 kDa, Protein from Homo sapiens)
- Human pi3k-alpha (p85/p110-h1047r) with qr-7909 binding at an allosteric site (Complex from Homo sapiens)
- Water (18 Da, Ligand)
CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-8557 binding at an allosteric site
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8w9b
Q-score: 0.496
Huang X, Wang K, Han J, Chen X, Wang Z, Wu T, Yu B, Zhao F, Wang X, Li H, Xie Z, Zhu X, Zhong W, Ren X
Structure (2024) 32 pp. 907-917.e7 [ Pubmed: 38582077 DOI: doi:10.1016/j.str.2024.03.007 ]
- Phosphatidylinositol 3-kinase regulatory subunit alpha (33 kDa, Protein from Homo sapiens)
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (124 kDa, Protein from Homo sapiens)
- Human pi3k-alpha (p85/p110-h1047r) with qr-8557 binding at an allosteric site (Complex from Homo sapiens)
- 1-[(1s)-1-(5-fluoranyl-3-methyl-1-benzofuran-2-yl)-2-methyl-propyl]-3-(1-oxidanylidene-2,3-dihydroisoindol-5-yl)urea (395 Da, Ligand)