Structure of the SecA-SecY complex with the substrate FtsQ-LacY(+1C)
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8y9y
Q-score: 0.522
Ou X, Ma C, Sun D, Xu J, Wang Y, Wu X, Wang D, Yang S, Gao N, Song C, Li L
Cell (2025)
- Protein translocase subunit seca (88 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- Protein translocase subunit sece (8 kDa, Protein from Geobacillus thermodenitrificans NG80-2)
- Protein translocase subunit secy (47 kDa, Protein from Geobacillus thermodenitrificans NG80-2)
- Substrate ftsq-lacy(+1c) (7 kDa, Protein from Escherichia coli K-12)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Seca-secy complex with the substrate ftsq-lacy(+1c) (Complex from Geobacillus thermodenitrificans NG80-2)
- Beryllium trifluoride ion (66 Da, Ligand)
Structure of the SecA-SecY complex with the substrate HmBRI-3TM
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8y9z
Q-score: 0.453
Ou X, Ma C, Sun D, Xu J, Wang Y, Wu X, Wang D, Yang S, Gao N, Song C, Li L
Cell (2025)
- Protein translocase subunit seca (88 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- Seca-secy complex with the substrate hmbri-3tm (Complex from Geobacillus thermodenitrificans NG80-2)
- Protein translocase subunit sece (8 kDa, Protein from Geobacillus thermodenitrificans NG80-2)
- Bacteriorhodopsin-i (11 kDa, Protein from Haloarcula marismortui ATCC 43049)
- Protein translocase subunit secy (47 kDa, Protein from Geobacillus thermodenitrificans NG80-2)
- Nanobody (13 kDa, Protein from Lama glama)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Beryllium trifluoride ion (66 Da, Ligand)
Structure of the SecA-SecY complex with the substrate FtsQ-LacY(+7C)
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8ya0
Q-score: 0.515
Ou X, Ma C, Sun D, Xu J, Wang Y, Wu X, Wang D, Yang S, Gao N, Song C, Li L
Cell (2025)
- Protein translocase subunit secy (47 kDa, Protein from Geobacillus thermodenitrificans NG80-2)
- Protein translocase subunit seca (87 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- Seca-secy complex with the substrate ftsq-lacy(+7c) (Complex from Geobacillus thermodenitrificans NG80-2)
- Cell division protein ftsq,lactose permease (7 kDa, Protein from Escherichia coli K-12)
- Nanobody (12 kDa, Protein from Lama glama)
- Protein translocase subunit sece (6 kDa, Protein from Geobacillus thermodenitrificans NG80-2)
- Nanobody (12 kDa, Protein from Lama glama)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Green fluorescent protein (25 kDa, Protein from Aequorea victoria)
- Beryllium trifluoride ion (66 Da, Ligand)
Structure of the SecA-SecY complex with the substrate FtsQ-LacY(+20C)
Resolution: 3.84 Å
EM Method: Single-particle
Fitted PDBs: 8ya2
Q-score: 0.343
Ou X, Ma C, Sun D, Xu J, Wang Y, Wu X, Wang D, Yang S, Gao N, Song C, Li L
Cell (2025)
- Protein translocase subunit seca (88 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- Protein translocase subunit sece (8 kDa, Protein from Geobacillus thermodenitrificans NG80-2)
- Cell division protein ftsq,lactose permease (8 kDa, Protein from Escherichia coli K-12)
- Protein translocase subunit secy (47 kDa, Protein from Geobacillus thermodenitrificans NG80-2)
- Seca-secy complex with the substrate ftsq-lacy(+20c) (Complex from Geobacillus thermodenitrificans NG80-2)
- Nanobody (12 kDa, Protein from Lama glama)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Green fluorescent protein (25 kDa, Protein from Aequorea victoria)
- Beryllium trifluoride ion (66 Da, Ligand)
Structure of the SecA-SecY complex with the substrate HmBRI-7TM
Resolution: 3.97 Å
EM Method: Single-particle
Fitted PDBs: 8yas
Q-score: 0.29
Ou X, Ma C, Sun D, Xu J, Wang Y, Wu X, Wang D, Yang S, Gao N, Song C, Li L
Cell (2025)
- Protein translocase subunit seca (88 kDa, Protein from Bacillus subtilis subsp. subtilis str. 168)
- Protein translocase subunit sece (8 kDa, Protein from Geobacillus thermodenitrificans NG80-2)
- Protein translocase subunit secy (47 kDa, Protein from Geobacillus thermodenitrificans NG80-2)
- Seca-secy complex with the substrate hmbri-7tm (Complex from Geobacillus thermodenitrificans NG80-2)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Beryllium trifluoride ion (66 Da, Ligand)
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8znz
Q-score: 0.547
Xu JG, Chen S, He Y, Zhu X, Wang Y, Ye Z, Zhou JC, Wu X, Zhang L, Ren X, Jia H, Yu H, Wei X, Feng Y, Chen X, Cui X, Pan X, Wang S, Xia S, Shang H, Pu Y, Xu W, Li H, Chen Q, Chen Z, Wang M, Yan X, Shi H, Li M, Xia Y, Bellelli R, Dong S, He J, Huang J, Cai CL, Zhu X, Zhan Y, Wan L
Nat Commun (2024) 15 pp. 10872-10872 [ DOI: doi:10.1038/s41467-024-55207-9 Pubmed: 39738003 ]
- Zinc ion (65 Da, Ligand)
- Hb0038 fab light chain (11 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Hb0038 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Hb0039 fab light chain (11 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Hb0039 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Cd73 complexed with hb0017 antibody coaktail (630 kDa, Complex from Homo sapiens)
- 5'-nucleotidase (58 kDa, Protein from Homo sapiens)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9jm0
Q-score: 0.492
Wang Y, Wang C, Guan Z, Cao J, Xu J, Wang S, Cui Y, Wang Q, Chen Y, Yin Y, Zhang D, Liu H, Sun M, Jin S, Tao P, Zou T
Cell Rep (2024) 43 pp. 114857-114857 [ Pubmed: 39395169 DOI: doi:10.1016/j.celrep.2024.114857 ]
- Rna (82-mer) (26 kDa, RNA from Escherichia coli)
- Rna (5'-r(p*cp*gp*up*ap*ap*gp*gp*gp*up*gp*cp*gp*cp*a)-3') (4 kDa, RNA from Escherichia coli)
- Nicotinamide (122 Da, Ligand)
- Dna (85-mer) (26 kDa, DNA from Escherichia coli)
- [(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methyl [hydroxy-[[(2r,3s,4r,5s)-3,4,5-trihydroxyoxolan-2-yl]methoxy]phosphoryl] hydrogen phosphate (559 Da, Ligand)
- Retron ec86 reverse transcriptase (37 kDa, Protein from Escherichia coli)
- Retron ec86-effector fiber (Complex from Escherichia coli)
- Retron ec86 putative ribosyltransferase/dna-binding protein (35 kDa, Protein from Escherichia coli)
Cryo-EM Structure of the Prostaglandin D2 Receptor 2-indomethacin Coupled to G Protein
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 8xxv
Q-score: 0.479
Xu J, Xu Y, Hou L, He X, Li Y, Zhao J, Meng X, Wang JJ, Wu Y, Zhang H, Li Y, Hu W, Yuan Q, Wu K, Cheng X, Jiang Y, Xia Y, Xu HE, Wu C
PNAS (2024) 121 pp. e2403304121-e2403304121 [ DOI: doi:10.1073/pnas.2403304121 Pubmed: 39665758 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- [(2~{r})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{s},3~{r},5~{r},6~{s})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{z})-octadec-9-enoate (837 Da, Ligand)
- Prostaglandin d2 receptor 2 (38 kDa, Protein from Homo sapiens)
- Indomethacin (357 Da, Ligand)
- Pd2r2-indomethacin-g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Cryo-EM Structure of the Prostaglandin D2 Receptor 2-PGD2 Coupled to G Protein
Resolution: 2.82 Å
EM Method: Single-particle
Fitted PDBs: 9iyb
Q-score: 0.475
Xu J, Xu Y, Hou L, He X, Li Y, Zhao J, Meng X, Wang JJ, Wu Y, Zhang H, Li Y, Hu W, Yuan Q, Wu K, Cheng X, Jiang Y, Xia Y, Xu HE, Wu C
PNAS (2024) 121 pp. e2403304121-e2403304121 [ DOI: doi:10.1073/pnas.2403304121 Pubmed: 39665758 ]
- Prostaglandin d2 receptor 2-pgd2-g protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Rattus norvegicus)
- [(2~{r})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{s},3~{r},5~{r},6~{s})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{z})-octadec-9-enoate (837 Da, Ligand)
- Prostaglandin d2 receptor 2 (43 kDa, Protein from Homo sapiens)
- Prostaglandin d2 (352 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 9chu
Q-score: 0.478
Xu J, Chen G, Wang H, Cao S, Heng J, Deupi X, Du Y, Kobilka BK
PNAS (2024) 121 pp. e2414544121-e2414544121 [ DOI: doi:10.1073/pnas.2414544121 Pubmed: 39565314 ]
- Fkbp1a (Complex from Homo sapiens)
- Calcineurin fused beta2ar (Complex from Homo sapiens)
- Protein phosphatase 3 catalytic subunit alpha (42 kDa, Protein from Mus musculus)
- 8-deethyl-8-[but-3-enyl]-ascomycin (804 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Homo sapiens)
- Protein phosphatase 3 catalytic subunit alpha (Complex from Mus musculus)
- Calcineurin fused beta2ar in complex with fkbp12 (Complex)
- Beta-2 adrenergic receptor,calcineurin subunit b type 1 (49 kDa, Protein from Homo sapiens)
- Noradrenaline (170 Da, Ligand)