mycobacterial efflux pump, substrate-bound state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8k1n
Q-score: 0.541
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L
PNAS (2024) 121 pp. e2403421121-e2403421121 [ Pubmed: 39226350 DOI: doi:10.1073/pnas.2403421121 ]
- Multidrug efflux system permease protein rv1217c (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Multidrug efflux system atp-binding protein rv1218c (33 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Rifampicin (822 Da, Ligand)
- Cardiolipin (1 kDa, Ligand)
- Ternary complex of an abc transporter rv1217c-1218c (120 kDa, Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
mycobacterial efflux pump, AMPPNP bound state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8k1o
Q-score: 0.597
Wang Y, Gao S, Wu F, Gong Y, Mu N, Wei C, Wu C, Wang J, Yan N, Yang H, Zhang Y, Liu J, Wang Z, Yang X, Lam SM, Shui G, Li S, Da L, Guddat LW, Rao Z, Zhang L
PNAS (2024) 121 pp. e2403421121-e2403421121 [ Pubmed: 39226350 DOI: doi:10.1073/pnas.2403421121 ]
- Multidrug efflux system permease protein rv1217c (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Multidrug efflux system atp-binding protein rv1218c (33 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Cardiolipin (1 kDa, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Ternary complex of an abc transporter rv1217c-1218c (120 kDa, Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
Cryo-EM structure of human OATP1B1 in apo state
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8hnb
Q-score: 0.402
Shan Z, Yang X, Liu H, Yuan Y, Xiao Y, Nan J, Zhang W, Song W, Wang J, Wei F, Zhang Y
Cell Res (2023) 33 pp. 940-951 [ DOI: doi:10.1038/s41422-023-00870-8 Pubmed: 37674011 ]
- Solute carrier organic anion transporter family member 1b1 (78 kDa, Protein from Homo sapiens)
- Oatp1b1 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human OATP1B1 in complex with bilirubin
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 8hnc
Q-score: 0.434
Shan Z, Yang X, Liu H, Yuan Y, Xiao Y, Nan J, Zhang W, Song W, Wang J, Wei F, Zhang Y
Cell Res (2023) 33 pp. 940-951 [ DOI: doi:10.1038/s41422-023-00870-8 Pubmed: 37674011 ]
- 3-[5-[(z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1h-pyrrol-2-yl]methyl]-4-methyl-1h-pyrrol-3-yl]propanoic acid (584 Da, Ligand)
- Solute carrier organic anion transporter family member 1b1 (78 kDa, Protein from Homo sapiens)
- Oatp1b1 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human OATP1B1 in complex with estrone-3-sulfate
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8hnd
Q-score: 0.474
Shan Z, Yang X, Liu H, Yuan Y, Xiao Y, Nan J, Zhang W, Song W, Wang J, Wei F, Zhang Y
Cell Res (2023) 33 pp. 940-951 [ DOI: doi:10.1038/s41422-023-00870-8 Pubmed: 37674011 ]
- Solute carrier organic anion transporter family member 1b1 (80 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Oatp1b1 (Complex from Homo sapiens)
- Estrone 3-sulfate (350 Da, Ligand)
Cryo-EM structure of human OATP1B1 in complex with simeprevir
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 8hnh
Q-score: 0.41
Shan Z, Yang X, Liu H, Yuan Y, Xiao Y, Nan J, Zhang W, Song W, Wang J, Wei F, Zhang Y
Cell Res (2023) 33 pp. 940-951 [ DOI: doi:10.1038/s41422-023-00870-8 Pubmed: 37674011 ]
- (2r,3ar,10z,11as,12ar,14ar)-n-(cyclopropylsulfonyl)-2-({7-methoxy-8-methyl-2-[4-(1-methylethyl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)-5-methyl-4,14-dioxo-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1h)-carboxamide (749 Da, Ligand)
- Solute carrier organic anion transporter family member 1b1 (80 kDa, Protein from Homo sapiens)
- Oatp1b1 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of human OATP1B1 in complex with DCF
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 8k6l
Q-score: 0.54
Shan Z, Yang X, Liu H, Yuan Y, Xiao Y, Nan J, Zhang W, Song W, Wang J, Wei F, Zhang Y
Cell Res (2023) 33 pp. 940-951 [ DOI: doi:10.1038/s41422-023-00870-8 Pubmed: 37674011 ]
- Solute carrier organic anion transporter family member 1b1 (80 kDa, Protein from Homo sapiens)
- Oatp1b1 (Complex from Homo sapiens)
- 2',7'-bis(chloranyl)-3',6'-bis(oxidanyl)spiro[2-benzofuran-3,9'-xanthene]-1-one (401 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Human ATP synthase state 1 subregion 3
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8h9f
Q-score: 0.573
Lai Y, Zhang Y, Zhou S, Xu J, Du Z, Feng Z, Yu L, Zhao Z, Wang W, Tang Y, Yang X, Guddat LW, Liu F, Gao Y, Rao Z, Gong H
Mol Cell (2023) 83 pp. 2137-2147.e4 [ DOI: doi:10.1016/j.molcel.2023.04.029 Pubmed: 37244256 ]
- Atp synthase subunit e, mitochondrial (7 kDa, Protein from Homo sapiens)
- Atp synthase subunit g, mitochondrial (11 kDa, Protein from Homo sapiens)
- Cardiolipin (1 kDa, Ligand)
- 1,2-diacyl-glycerol-3-sn-phosphate (704 Da, Ligand)
- Atp synthase subunit f, mitochondrial (10 kDa, Protein from Homo sapiens)
- Atp synthase subunit atp5mj, mitochondrial (6 kDa, Protein from Homo sapiens)
- Atp synthase f(0) complex subunit c1, mitochondrial (7 kDa, Protein from Homo sapiens)
- Atp synthase subunit epsilon, mitochondrial (5 kDa, Protein from Homo sapiens)
- Atp synthase subunit gamma, mitochondrial (30 kDa, Protein from Homo sapiens)
- Atp synthase subunit d, mitochondrial (18 kDa, Protein from Homo sapiens)
- Atp synthase subunit a (24 kDa, Protein from Homo sapiens)
- Atp synthase subunit delta, mitochondrial (15 kDa, Protein from Homo sapiens)
- Atp synthase protein 8 (8 kDa, Protein from Homo sapiens)
- Atp synthase f(0) complex subunit b1, mitochondrial (24 kDa, Protein from Homo sapiens)
- Human atp synthase (600 kDa, Complex from Homo sapiens)
Human ATP synthase F1 domain, state 1
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8h9e
Q-score: 0.622
Lai Y, Zhang Y, Zhou S, Xu J, Du Z, Feng Z, Yu L, Zhao Z, Wang W, Tang Y, Yang X, Guddat LW, Liu F, Gao Y, Rao Z, Gong H
Mol Cell (2023) 83 pp. 2137- [ DOI: doi:10.1016/j.molcel.2023.04.029 Pubmed: 37244256 ]
- Atp synthase subunit alpha, mitochondrial (55 kDa, Protein from Homo sapiens)
- Atpase inhibitor, mitochondrial (9 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Human atp synthase (600 kDa, Complex from Homo sapiens)
- Atp synthase subunit gamma, mitochondrial (30 kDa, Protein from Homo sapiens)
- Atp synthase subunit beta, mitochondrial (51 kDa, Protein from Homo sapiens)
- Atp synthase subunit o, mitochondrial (20 kDa, Protein from Homo sapiens)
Human ATP synthase F1 domain, state2
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8h9i
Q-score: 0.564
Lai Y, Zhang Y, Zhou S, Xu J, Du Z, Feng Z, Yu L, Zhao Z, Wang W, Tang Y, Yang X, Guddat LW, Liu F, Gao Y, Rao Z, Gong H
Mol Cell (2023) 83 pp. 2137- [ DOI: doi:10.1016/j.molcel.2023.04.029 Pubmed: 37244256 ]
- Atp synthase subunit alpha, mitochondrial (55 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Human atp synthase (600 kDa, Complex from Homo sapiens)
- Atp synthase subunit gamma, mitochondrial (30 kDa, Protein from Homo sapiens)
- Atp synthase subunit beta, mitochondrial (51 kDa, Protein from Homo sapiens)
- Atp synthase subunit o, mitochondrial (20 kDa, Protein from Homo sapiens)