Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8gd9
Q-score: 0.534
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ Pubmed: 37478163 DOI: doi:10.1073/pnas.2216329120 ]
- 4-({2-[(1r,2r,3r,5s)-3,5-dihydroxy-2-{(3s)-3-hydroxy-4-[3-(methoxymethyl)phenyl]butyl}cyclopentyl]ethyl}sulfanyl)butanoic acid (440 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Prostaglandin e2 receptor ep4 subtype (53 kDa, Protein from Homo sapiens)
- Prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Nb35 (13 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein subunit gamma (12 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8gda
Q-score: 0.506
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ Pubmed: 37478163 DOI: doi:10.1073/pnas.2216329120 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Prostaglandin e2 receptor ep4 subtype (53 kDa, Protein from Homo sapiens)
- Prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Nb35 (13 kDa, Protein from Lama glama)
- (2s,5r)-5-[(1e,3s)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl]-1-[6-(1h-tetrazol-5-yl)hexyl]pyrrolidin-2-ol (421 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein subunit gamma (12 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8gdb
Q-score: 0.57
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ Pubmed: 37478163 DOI: doi:10.1073/pnas.2216329120 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- (z)-7-[(1r,2r,3r)-3-hydroxy-2-[(e,3s)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid (352 Da, Ligand)
- Prostaglandin e2 receptor ep4 subtype (53 kDa, Protein from Homo sapiens)
- Prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Nb35 (13 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein subunit gamma (12 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Prostaglandin E2 Receptor 3 Coupled to G Protein
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8gdc
Q-score: 0.401
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ Pubmed: 37478163 DOI: doi:10.1073/pnas.2216329120 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Prostaglandin e2 receptor ep3 subtype (43 kDa, Protein from Homo sapiens)
- (z)-7-[(1r,2r,3r)-3-hydroxy-2-[(e,3s)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid (352 Da, Ligand)
- Prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein subunit gamma (12 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Prostaglandin E Receptor EP4 Coupled to G Protein
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8gcm
Q-score: 0.482
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ Pubmed: 37478163 DOI: doi:10.1073/pnas.2216329120 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- Prostaglandin e2 receptor ep4 subtype (53 kDa, Protein from Homo sapiens)
- (5s)-5-[(3r)-4,4-difluoro-3-hydroxy-4-phenylbutyl]-1-[6-(1h-tetrazol-5-yl)hexyl]pyrrolidin-2-one (421 Da, Ligand)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Cryo-EM Structure of the Prostaglandin E2 Receptor 4 Coupled to G Protein
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8gcp
Q-score: 0.463
Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP
PNAS (2023) 120 pp. e2216329120-e2216329120 [ Pubmed: 37478163 DOI: doi:10.1073/pnas.2216329120 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Cryo-em structure of prostaglandin e receptor ep4 coupled to g protein (Complex from Homo sapiens)
- (z)-7-[(1r,2r,3r)-3-hydroxy-2-[(e,3s)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid (352 Da, Ligand)
- Prostaglandin e2 receptor ep4 subtype (53 kDa, Protein from Homo sapiens)
- Scfv (32 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein subunit gamma (12 kDa, Protein from Homo sapiens)
Cryo-EM structure of Fenoldopam bound dopamine receptor DRD1-Gs signaling complex.
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 7ckw
Q-score: 0.431
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ DOI: doi:10.1016/j.cell.2021.01.028 Pubmed: 33571432 ]
- D(1a) dopamine receptor (50 kDa, Protein from Homo sapiens)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Nanobody 35 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- (1r)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol (305 Da, Ligand)
- Em stucture of complex-1 (Complex from Homo sapiens)
- Protein-1 (Complex)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of A77636 bound dopamine receptor DRD1-Gs signaling complex
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7ckx
Q-score: 0.389
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ DOI: doi:10.1016/j.cell.2021.01.028 Pubmed: 33571432 ]
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- Em structure of protein-2 (Complex)
- D(1a) dopamine receptor (50 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (1r,3s)-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1h-isochromene-5,6-diol (329 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (Complex from Homo sapiens)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of PW0464 bound dopamine receptor DRD1-Gs signaling complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7cky
Q-score: 0.254
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ DOI: doi:10.1016/j.cell.2021.01.028 Pubmed: 33571432 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (49 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (Complex from Homo sapiens)
- Complex structure-3 (Complex)
- 6-[4-[3-[bis(fluoranyl)methoxy]pyridin-2-yl]oxy-2-methyl-phenyl]-1,5-dimethyl-pyrimidine-2,4-dione (389 Da, Ligand)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of Dopamine and LY3154207 bound dopamine receptor DRD1-Gs signaling complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ckz
Q-score: 0.451
Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z
Cell (2021) 184 pp. 943-956.e18 [ DOI: doi:10.1016/j.cell.2021.01.028 Pubmed: 33571432 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Complex structure-4 (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha, beta, gamma (Complex from Homo sapiens)
- Nanobody 35 (Complex from Lama glama)
- D(1a) dopamine receptor (49 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- D(1a) dopamine receptor (Complex from Homo sapiens)
- 2-[2,6-bis(chloranyl)phenyl]-1-[(1s,3r)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1h-isoquinolin-2-yl]ethanone (450 Da, Ligand)
- Nanobody 35 (16 kDa, Protein from Lama glama)
- Cholesterol (386 Da, Ligand)
- L-dopamine (153 Da, Ligand)